... characterized by the presence of a vinyl ether substituent at the sn-1position of the glycerol backbone. They are especiallyabundant in electrically active tissues, such as brain, wheremost of them ... on the type of PLA2, this cleavage leads to theirinactivation (in the case of the cytosolic PLA2,typeIV,without arachidonate-phospholipid remodeling activity) or activation (in the case of ... stimulation of the Ca2+-independentplasmalogen-selective PLA2may account for the decreasedlevels of Etn plasmalogens found in the affected regions of the brain in Alzheimer’s disease, such as the...