Báo cáo khoa học: Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity pdf
... important membrane phospholipids
in promoting efficient binding, complex assembly and
enzyme catalysis in vivo.
Membrane affinity of a Gla protein often correlates
with its membrane localized activity. ... into the Gla protein membrane
interaction and identify new reagents with varying
degrees of anticoagulant potency that may be of use
for testing in murine models of...
... Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of
Copenhagen, Frederiksberg, Denmark
3 Department of Biology, ETH Zu
¨
rich, Switzerland
4 Department of Biology, ... evolution of low -affinity domains is a
recurring and functionally important theme in plastid-
ial starch metabolism.
Results and Discussion
Identification and bioinformatic...
... the
average IC
50
concentration of the peptide against that group
of cancers and the number of tumours, out of 60 tested, that
were affected by the particular peptide. For details of how
the IC
50
value ... active
peptides, suggests that the anticancer activity is also due to
penetration and disruption of the membranes of the cancer
cells. The selectivity of these pep...
... radius
dependence on number of residues for a polypeptide
chain in ideal random coil, b-strand and PII-helix
conformations. Measurements of translational diffu-
sion for the Ab(12–28) and Ab(1–9) peptides were
performed ... controller. A quartz cell with
2 mm optical path was used. The spectral range was 190–
250 nm with a resolution of 0.2 nm and a bandwidth of 2 nm.
A scan...
... selenolate and
enhance the GPX-like activity of diselenides [11].
Although some GPX mimics show some increased
activity, most show only limited catalytic enhancement.
Based on an understanding of the ... the 6-CySeCD-cata-
lyzed reduction of hydroperoxides by GSH and other species. One
unit of enzyme activity is defined as amount of mimic that utilizes
of 1 lmol of NAD...
... immune and endocrine systems, components of
signaling pathways and of the ubiquitin–proteasome
pathway, and genes of tumor viruses. Activation of
cell-cycle regulators, proto-oncogenes and genes
involved ... binds to the P1 and P2 TATA boxes. (A, B) EMSAs were performed with radioactively labeled oligonucleotides P1 or P2 and with
purified TBP and TFIIA or as control...
... the
etiology of cancer of the respiratory and digestive
tracts, and in other diseases [10,32].
In summary, the reactivity of aldehydes with zinc
proteins demonstrates that elevated levels of aldehydes
affect ... thionein with acetaldehyde for 30 min,
removing the excess of aldehyde with 1 unitÆmL
)1
of yeast
ADH, 2 mm NADH and 100 mm potassium chloride, and
then assa...
... sentences with a script
that randomly deletes, inserts, or misspells a word;
and Och et al. (2004) and Cherry and Quirk (2008)
both use the 1-best output of a machine translation
system. Examples of ... component
of all speech recognition and machine translation
systems, and a great deal of research centers around
refining models (Chen and Goodman, 1998), ef-
ficient stora...
... put forward a number of new features to
encode the structural information.
Category of c
k
’s parent; head word and POS of
head word of parent, left sibling and right sibling
of c
k
.
Lexicalized ... rules: Conjuction of
rewrite rule and head word of its corresponding
RHS. These features of candidate (lrw-c) and its
parent (lrw-p) are used. For example, this lrw-
c fea...
... relationship to
Agent and Recipient is represented with the
predicates giver and givee. The subject and
oblique-object of the sentence fill those
arguments, and the actual change of possession is ...
frames
5
and they improved ResearchCyc parser
performance by 20%. However, with 35% of
frames in the VxC comparison and 16% in the
parse test failing because of c...