Báo cáo khoa học: Characterization of the angiogenic activity of zebrafish ribonucleases pptx
Báo cáo khoa học: Bacitracin inhibits the reductive activity of protein disulfide isomerase by disulfide bond formation with free cysteines in the substrate-binding domain pptx
... ring of bacitracin A (937.33).Negative ion mode CID-TOF ⁄ TOF MS analysis of the same precursor yielded the corresponding signaturepeaks (m ⁄ z 1404.88, 1438.82 and 1470.80) of the otherpart of ... the IC50values forbacitracin-mediated inhibition of PDI reductive activ-ity. Furthermore, on the basis of our results, the inhib-itory activity of the bacitracin mixture will depend on the ... with expression of PDI activity as absor-bance at 100 min as a percentage of the absorbance of the control reaction containing no inhibitor, after subtraction of the absorbance of the uncatalyzed...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... havedetectable activity to both pullulan and panose (data notshown).Prediction of the positions of amino acid residues whosesubstitutions resulted in the reduction of the IPU activity While the study of ... iscomposed of residues 25–540. The overall structure of the model of IPU and the mutated residues in this study areshown in Fig. 3. To elucidate the mechanism of the substrate recognition of IPU, ... enzyme lost the activity for pullulan ( 0.4% of the wild-type IPU) and the activity for p anose w as almost undetectable ( 0.1%) under the given conditions. The W31F enzyme had only 38% activity for...
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Tài liệu Báo cáo khoa học: "Methods for the Qualitative Evaluation of Lexical Association Measures" doc
... we find: (i) Examination of 50% of the datain the SLs leads to identification of between 75%(AdjN) and 80% (PNV) of the TPs. (ii) For the first 40% of the SLs, and lead to the worstresults, with ... fre-quency) and the weak measures ( and ).In the second half of the data in the SLs, how-ever, there is virtually no difference between ,, and the other measures, with the exception of mere co-occurrence ... approach, the set of the highest rankedword combinations is evaluated for each measure,and the proportion of TPs among this -best list (the precision) is computed. Another measure of goodness is the...
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Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy pptx
... direct exploitation of the structural results of the former to explain the mechanism of CaM activation of the latter. Crystallizationand resolution of the 3D structures of AC and AC–CaM,which ... couplingFig. 5. Binding of Ant-dATP to AC (d) and AC–CaM (m). The degree of binding of the ligand was calculated from the value of the ampli-tude of the long lifetime, which characterizes the bound fluorescentnucleotide.Fig. ... respectively, the values of the center and the normalized amplitude of each lifetime peak.cIiare the values of the partialintensity of the ithcomponent Ii¼ aisi/<s>.d The mean...
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Báo cáo khoa học: Intrabodies against the EVH1 domain of Wiskott–Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells potx
... region. The association of WASP and the Arp2 ⁄ 3 complex activates the actinnucleation activity of the Arp2 ⁄ 3 complex [23].To investigate further the function of the WASP-EVH1 domain in the ... 5B).Therefore, the EVH1 domain of WASP is not func-tional, at least in the Ag receptor-induced proliferativeresponse of B cells.T cells from the other three 21SHL transgenic linesand the other ... respectively. The appropriate cDNA fragments of the VHand VLregions were then generated by RT-PCR. A compar-ison of the VHand VLamino-acid sequences of clones 18 and 21 is shown in Fig. 1B. All of...
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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
... how the second kinase in the cascade determines the time dependence of the activity of the third kinase, we varied the Vmax of the secondkinase reaction and recalculated the concentration of the ... example, the activity of the second kinase exerted substantial control on signalingamplitude, both in the initial phase of signaling andFig. 2. Time profile of the activity of the four proteins in the ... are controlled by the kinases or phosphatasesin the system, and whether they are controlled differ-entially by some or all of them. On the basis of the antagonistic action of the kinases and...
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Báo cáo khoa học: "Search in the Lost Sense of “Query”: Question Formulation in Web Search Queries and its Temporal Change" pptx
... clusteringbut on understanding the expression of intent.3 MethodWe address the main thesis of the work by retrospec-tively studying queries issued to a search engine over the course of 12 consecutive months.Q-queries. ... compute a linear regression of Q-level across 12 months, conduct a hypothesistest (with the null hypothesis being the slope of the regression equal to zero), and report the P -value fortwo-tailed ... higher7An explanation of why the upward trend starts at the end of 2007 is beyond the scope of this work; we postulate that thiscoincides with the rise in popularity of community-based Q&Asites.Q-rate...
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Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx
... changes of the pro-tomer resulting in a displacement of the cofactor bound at the active site by 2.6 A˚(mean distance) in the direction of the iron and Glu286 which causes a loss of the stabilizinghydrogen ... complex, the binding of the cofactor at the active site results in the formation of stabilizing hydrogen bonds between the dihydroxypropyl side-chain and the carbonyl oxygen of Ser23 in the autoregulatory ... and hydrogen bondingnetwork of the pterin cofactor in the three structures.Superpositions of the binary and ternary complexes of hPAH onto the crystal structure of the ligand-free dimericrPAH...
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Báo cáo khoa học: Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa potx
... influenced by pH.Rate of Meta II decay as measured by retinalrelease The rate of retinal release, which parallels the Meta IIdecay of the protein in the case of the WT under the condi-tions used, ... volume of 650 lL; spectra were normalized to the fluorescence inten-sity of the sample before illumination. For determining the rates of Gt activation, the initial slopes of the first 30–60 s of data ... activationobserved. In terms of the thermal stability, the activeconformation of the G51V mutant was less stable than the active conformation of the mutant G89D and the ability to activate Gt...
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Báo cáo khoa học: Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells ppt
... to the pole of the monoastral spindleand also diffused all along the monoastral microtu-bules (Fig. 5B). In the presence of 24 lm curcumin,Eg5 primarily remained confined to the pole of the monopolar ... microtubule dynamics. The resultssuggest that tubulin is one of the major targets for the antiproliferative activity of curcumin.ResultsCurcumin inhibited the proliferation of MCF-7cells and ... depolymeriza-tion of the interphase microtubules after 6 h of incuba-tion, suggesting that curcumin exerted a strongerdepolymerizing effect on the microtubules of the mito-tic cells than those of the interphase...
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Từ khóa: chuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Sở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ