... hydrolysis, resulting in anincrease in intracellular sterol trafficking. It is unclear, then,whether the corresponding increase in pregnenolone pro-duction results from an increase in free sterol ... ([14,15]). In the latter case, the concentration of Adrp limits the production of pregneno-lone [15] through a mechanism involving oxidized Adxp,that is in excess in the human placenta [16]. Whether ... (5¢-cagtagagacatgggagatcccccgcggaattcgagctcggtacccgggTCATTCTTTATTTAGAGCATCCAGC-3¢). The sequences in lower-case are complementary to the end of the GAL10/CYC1 promoter (lip1) and to the beginning of the PGK1 terminator (lip2). The 1647 bp PCRfragment was transformed into...