Báo cáo khoa học: Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism docx
Báo cáo khoa học: Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism docx
... compilation ª 2009 FEBS 3453 Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism Michelle Cook Sangar1, Hindupur K. Anandatheerthavarada1, ... of 250 lLÆmin)1was used with solvents A(0.1% HCO2HinH2O, v ⁄ v) and B (0.1% HCO2HinCH3CN) and the gradient: t 0–1 min, 100% A; t 1 min;t 1–1 6 min, 0–1 00% B; t 1 6–2 0 min, hold at ... with a possible role in drug metabolism and drug- induced toxicity.ResultsLocalization of CYP2D6 in human liver mitochondriaMitoplast and microsomal isolates from 20 human liver samples were...
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Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf
... bind, leading to a reduced P450 producing a char-acteristic CO-binding difference spectrum with anabsorbance maximum at 450 nm. This P450 CO com-plex is inactive and has given the name to P450 ... domains involved in heme binding and proton transfer [2]. P450s have beencategorized in families and subfamilies. They belong tothe same family when they share ‡ 40% amino acididentity and ... (amphotericin,nystatin, candicidin, pimaricin and rimocidin). Allthese clusters contain a P450 gene homologue to amp-hN and NysN associated to the C-16 oxidation. Thesepolyketide-specific P450 sequences...
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Tài liệu Báo cáo khoa học: Fatty acid synthesis Role of active site histidines and lysine in Cys-His-His-type b-ketoacyl-acyl carrier protein synthases ppt
... binding of ACP tothe docking site followed by a conformational change in ACP proposed to inject the acyl chain into the sub-strate-binding pocket [32]. If a similar mechanism isinvolved in ... statistics.WT–C8 WT H298Q H298Q–C12 H298E H298E–C12 K328A K328A–C12 K328RResolution (A˚) 15. 0–2 .40 29. 7–1 .9 26. 1–1 .86 116. 4–1 .95 32. 5–2 .20 31. 6–2 .00 29. 8–1 .70 37. 9–2 .00 29. 9–2 .00Rmergea(%) 7.6 (17.9)b12.4 ... cooled to 100 K in a stream of gaseous N2after a 1 min incubation in aP. von Wettstein-Knowles et al. Histidines and lysine in KAS I ⁄ KAS II catalysisFEBS Journal 273 (2006) 69 5–7 10 ª 2006 The...
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Tài liệu Báo cáo khoa học: "The Software Architecture for the First Challenge on Generating Instructions in Virtual Environments" docx
... didn’t understand the previous instruction; and handleStatusInformation gets calledonce per second and after each user action toinform the server of the player’s position and orientation and the ... player in a 3D game worldwith an NLG system over the Internet. It is imple-mented and open source, and can be a used onlineduring EACL at www.give-challenge.org. In Section 2, we give an introduction ... describing the experi-ence of a user participating in the evaluation, thenature of the data we collect, and our scientificgoals. Then we explain the software architecturebehind the scenes and...
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Báo cáo khoa học: Organizational constraints on Ste12 cis-elements for a pheromone response in Saccharomyces cerevisiae docx
... contrast, recombinantSte12 and Tec1, both produced in insect cells, arecapable of binding individually to an FRE-containingoligonucleotide in vitro (Fig. 2C, lanes 1 and 2), and form a higher-order ... the binding ofrecombinant maltose-binding domain-Ste12 fusions orSte12 DNA-binding domain fragments to an FRE[15], or the FUS1 promoter in vitro [23]. We haveexpressed 6-His-Ste12 in insect ... (contain-ing a single PRE) in the absence of Tec1 [2], indicatingthat Ste12 is prevented from binding a single PRE in vivo on its own. This effect is likely mediated by theinhibitor proteins...
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Báo cáo khoa học: "Using Leading Text for News Summaries: Evaluation Results and Implications for Commercial Summarization Applications" ppt
... queries to the headline and leading text than if they were to apply their queries to the full text. Documents in our news database have several text fields including HEADLINE and BODY fields. ... these documents in order to include the logical lead in most instances. Using a fixed amount of leading text regardless of document length would have resulted in LEADs that include 1364 too ... documents that contain "Clinton" in the LEAD and "budget" any- where in the document. Customers who use LEAD routinely combine it with the HEADLINE field. We tested...
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Báo cáo khoa học: RIP1 comes back to life as a cell death regulator in TNFR1 signaling docx
... of RIP1 and subsequent binding to the ubiquitin-recognitiondomain of NEMO. NEMO itself can be conjugated tolinear polyubiquitin chains joined head-to-tail by thelinear ubiquitin chain assembly ... NEMO a C-terminal ubiquitin bind-ing zinc finger in conjunction with the NOA ⁄ UBANconfers much higher affinity for binding K63-linkedpolyubiquitin chains than head to tail conjugated lin-ear polyubiquitin ... FEBSpresence of ubiquitinated and nonubiquitinated RIP1,for example, pro-survival factors that contain ubiqu-itin-binding domains such as the IAPs [46,47] and A20-binding inhibitor of NF-jB [40,48]...
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Báo cáo khoa học: Cytosol–mitochondria transfer of reducing equivalents by a lactate shuttle in heterotrophic Euglena docx
... cyanide-insensitive alternative oxidase and an antimycin-insensitive, myxothiazol-sensitive, quinol- cytochrome c oxidoreductase [1]. It also contains activemembrane-bound NAD+-independentD -and L-lactatedehydrogenases ... reachingphase III. In consequence, the iLDH/COX ratio increased in the three culture media, from 0.4 to 0.5 in phase I, to 0. 8– 2.0 in phase III. Determination of the cytochrome a + a3content in isolated ... insolublecomplexes. For instance, oxalate may also inhibit liver pyruvate carboxylase as well as pyruvate kinase frommuscle, erythrocytes and liver, with inhibition constantvalues of 6–1 1 lM[36]. In hepatocytes,...
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Báo cáo khoa học: "Distributed Word Clustering for Large Scale Class-Based Language Modeling in Machine Translation" docx
... (Goodman and Gao, 2000) as well as lower-ing the complexity of related clustering algorithms(Whittaker and Woodland, 2001). In (Emami and Jelinek, 2005) a clustering algo-rithm is introduced ... linearly in the size of the vocabulary.With Nprec and Nsuccdenoting the average numberof clusters preceding and succeeding another cluster,B denoting the number of distinct bigrams in ... number of parameterswhen scaling to higher-order n-grams (Goodman and Gao, 2000), and even despite the increasing size and decreasing sparsity of language model training cor-pora (Brants et al.,...
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Báo cáo khoa học: Human mitochondrial transcription factor A possesses multiple subcellular targeting signals pptx
... to show a higher affinity for mitochondrial heavy strand promoter and light strandpromoter [13]. TFAM binding to DNA inducesunwinding and bending [14], and the mitochondrial TFAM content (approximately ... fusionproteins, implying involvement of these residues in nuclear targeting. Interestingly, mutations in threeinvariant residues (P66, W88, and K96) resulted in asignificant increase in the proportion ... is weak, and both N-terminal and C-terminal flanking sequences enhance thenuclear targeting of EGFP. Finally, several mutations in the HMG1domain increased the mitochondrial targeting of the...
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