Báo cáo khoa học: Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein potx

Báo cáo khoa học: "Parsing with Treebank Grammars: Empirical Bounds, Theoretical Models, and the Structure of the Penn Treebank" ppt

Báo cáo khoa học: "Parsing with Treebank Grammars: Empirical Bounds, Theoretical Models, and the Structure of the Penn Treebank" ppt

... NN:[2,3]) 3.1 Time The parser has an theoretical time bound, where is the number of words in the sentence to be parsed, is the number of nonterminal categories in the grammar and is the number of (active) ... shows the effect of the tree transforms on traversal counts. The NOUNARIES settings are much more efficient than the others, however this efficiency comes at...
Ngày tải lên : 17/03/2014, 07:20
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Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx

Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx

... in the genome of living cells is naturally stochastic on the one hand, and influenced by the actual structural and functional state of the given chromatin domain on the other. Moreover, some of the ... DNA binding of p73 proteins We tested the influence of DNA modification with cisplatin on the binding of two p73 isoforms, p73d and p73b, to the p21 target...
Ngày tải lên : 19/02/2014, 05:20
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Báo cáo khoa học: acids in the brain: D-serine in neurotransmission and neurodegeneration ppt

Báo cáo khoa học: acids in the brain: D-serine in neurotransmission and neurodegeneration ppt

... in culture: synthesis and release of serine and lactate. Glia 27, 239–248. 75 Goff DC & Coyle JT (2001) The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. ... (B) Staining of neurons in the stratum pyramidale (Pyr) of the CA1 region of the hippocampus. (C) Staining for serine race- mase in the pyramidal cell layers and den...
Ngày tải lên : 30/03/2014, 04:20
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Báo cáo khoa học: "Phrase-based Statistical Language Generation using Graphical Models and Active Learning" potx

Báo cáo khoa học: "Phrase-based Statistical Language Generation using Graphical Models and Active Learning" potx

... food(Indian), near (The Red Lion)). The order of the constraints in the description was randomised to reduce the effect of priming. The annotators were then asked to align the attributes (e.g., Indicate the ... taken from the test folds of the cross-validation experiment presented in Sec- tion 5.2, i.e. the models are trained on up to 90% of the data and th...
Ngày tải lên : 17/03/2014, 00:20
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf

Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf

... terminals (post-synaptic). The localization of the synaptic vesicle proteins in both pre- and post-synaptic regions as a result of the lack of LRK-1 apparently is not a random event because the mislocalization of the ... [34] were the first to report the generation of LRRK2 KO mice. Taking advantage of the lack of LRRK2 expression in these mice, they performed...
Ngày tải lên : 23/03/2014, 04:20
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Báo cáo khoa học: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases pot

Báo cáo khoa học: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases pot

... networks on the basis of sequence information is currently not an option. Therefore, given the scarce knowledge on relevant ligands and substrates and the experimental draw- backs of overexpression ... identification of RPTP ligands and the mapping of their binding sites on RPTP ectodomains may yield additional peptide tools to fine-tune RPTP signalling, much like the...
Ngày tải lên : 30/03/2014, 04:20
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Báo cáo khoa học: Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein potx

Báo cáo khoa học: Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein potx

... protein ligand interactions and the surface of the binding site in the lower binding site. (C) Closer view (from the bottom) of the protein ligand interac- tions and the surface of the binding site in the upper binding ... some of the residues to denote the difference in their solvent exposure as a result of the presence of the ligand; the...
Ngày tải lên : 29/03/2014, 22:21
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Tài liệu Báo cáo khoa học: Comparison of the substrate specificity of two potyvirus proteases doc

Tài liệu Báo cáo khoa học: Comparison of the substrate specificity of two potyvirus proteases doc

... interpret the kinetic data. A comparison of the two structures and the experimental data suggested that the differences in the specificity of the two enzymes may be mainly due to the variation in their ... modeling, the Arg side chain of the substrate may partially compensate for the loss of the Lys side Table 1. Comparison of the specificity of TEV an...
Ngày tải lên : 19/02/2014, 16:20
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Báo cáo khoa học: Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall pot

Báo cáo khoa học: Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall pot

... role of antimicrobial action at the bacterial cell wall level. An understanding of the interaction between anti- microbial proteins and their target at the bacterial envelope should aid in the ... membrane and label all bacterial cells, propidium iodide can only access the content of membrane damaged cells, competing and displacing the bound syto 9. Therefore, the in...
Ngày tải lên : 22/03/2014, 21:20
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... structure of MAP2 and the alignment of v-KIND -binding core (BD) region of MAP2 CD2 domain (702–744 aa) in human, mouse and Gallus This supplementary material can be found in the online version of this ... in the cell lysates. Taken together, these data indicate that the MAP2- binding core site of v-KIND is sufficient for the v-KIND-MAP2 interaction within cells. T...
Ngày tải lên : 14/02/2014, 19:20
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