... mutant toxins and the
analysis of their binding activity to the receptor to
investigate the role of mutated amino acid residues; (b)
the analysis of the influence of the modification of the
cysteine ... comparison with DF, the inhibitory effect of IAF
should be restricted to a narrower region.
The region on Cry1Aa toxins for contact and
interac...
... subtracted
from the consumption recorded after addition of 1 m
M
phenol. The effects of PHI and PHR concentrations on the
overall PH activity were evaluated by systematic variation
of PHI concentration (0.3; ... shown in the inset,
the progressive decrease of the molecular ellipticity at
k ¼ 200 nm (the absorption region of the peptide bond)
reflects the occurr...
... a soft ligand and
therefore shows a preference for soft metals. More-
over the structures of metallothioneins are not rigid
and hence there is little selectivity concerning the size
of the ion. ... to air resulted in the slow formation of a
disulfide linkage by cysteine oxidation of the a-domain
and a concominant release of one Zn ion, but the spec-
troscopic feat...
... to stabilization of the sol state of
silica. One mechanism for the gel to sol conversion
could be hydrolysis of the oxygen bridge of the poly-
merized ⁄ polycondensed silicic acid. The linkage ... bonding between the imidazole nitrogen of
the conserved His and the hydroxyl of the active-site
Ser increases the nucleophilicity of the Ser oxygen,
facilitat...
... between the subunits in the
interface region create conformational changes in both
chains. The molecular recognition by the ion channel
binding region of the Kunitz module differs from that
of other ... other
serine proteinases, the loss of proteinase activity at
high pH probably results from the deprotonation of
the N-terminus and the disruption of the s...
... of
multimerization promoted by the N terminus and the
coiled-coil domain [16,17]. However, the consequences
of multimerization and association with other proteins
for in vivo activity regulation of DMPK ... clear.
Activation of Citron kinase and ROCK-I is mediated
by RhoA binding to a Rho -binding domain located in
the C-terminal part of the coiled-coil region...
... if
L
-isoleucine and
L
-valine are degraded in A. nidulans as they
are in yeast, then the formation and conversion of the
Fig. 2.
D
-Galacturonic acid provokes induction of the alc genes.
(A) Northern blot analysis ... loss -of- function mutants. In one of the
crossfed strains, alc500 TalcR, proper inducibility of alcR
and aldA was demonstrated by Northern blot analys...
... ques-
tion 1 through S1. We call contextual information
the context of a question in this paper.
A summary of forum threads in the form of
question-context-answer can not only highlight the
main content, ... predicted
rums), and then use them to expand question and
compute cosine similarity.
The structural features of forums provide strong
clues for contexts. For examp...
... regulates the expression
level of the P2X
7
receptor.
Results
Presence of the P2X
7
receptor and its
modification in alveolar epithelial cell lines
First, we tested the expression of the P2X
7
receptor ... result for P2X
4
in cardiac myocytes. They demonstrated that the gly-
cosylation of the P2X
4
receptor is required for its
localization to the cytoplasm...
... easy-to-use and fast. A new system can
be built using only a few commands. To
control the system, users only need to
modify a configuration file. In addition to
the special attention to usability, the ... types),
including Monotone (M), Swap (S), and Discontinuous (D).
20
probabilities of the three orientations
(Galley and Manning, 2008).
3.2 Translation Rule Extraction...