... knockdown of allShc isoforms strongly reduced Decma-induced Erk phos-phorylation. Moreover, expression of silent mutants of Shc isoforms showed that only p46Shc and p52Shcres-cued the effect of ... Biomedicine,University of Basel, Switzerland) and details will be pub-lished elsewhere.Plasmids and siRNAsConstruction of expression vectors for HA-tagged full-length mouse p46shc, p52shc, and p66shc and ... Institute for Molecular Biomedicine and Institute of Cell Biology, University of Munster, Ger-many) and R. Kemler (Max-Planck Institute of Immuno-logy, Department of Molecular Embryology, Freiburg,Germany)....