Báo cáo Y học: Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity docx
Báo cáo Y học: Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity docx
... Authors Journal compilation ª 2008 FEBS Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity Silje A. Solheim1,2, Evangelia ... substrates.Results and DiscussionPhosphorylation of the adaptor protein PAG is depen-dent on an initial interaction between the first proline-rich region of PAG and the SH3-domain of the kinase Fyn. Our ... investigations have highlighted the importance of the Fyn SH3-domain interaction in initi-ating the association with PAG, and how this affectstyrosine phosphorylation and thereby the functionalityof...
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Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... sites and ligands, respectively, and [EL] is the concentration of boundligand. The total concentration of sites can be expressed asN[E]0, the product of total protein concentration ([E]0) and the ... the activity of a number of key enzymessuch as cyclooxygenase [9], protein kinase C [10], protein tyrosine kinases [11] and a Ca2þ-dependent endonuclease[12]. Many of these processes/enzymes ... the membrane to the luminal side and are of low affinity. Furthermore, in the E1 confor-mational state, the ATPase can be phosphorylated by ATP,which drives the translocation process. From the...
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Báo cáo y học: "Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study"
... two symptoms (physical or mental) which bother you the most. Write them on the lines. Now consider how bad each symptom is, over the last week, and score it by circling your chosen number. SYMPTOM ... This may have had some impact on the observed findings as well as influencing the external validity of the study.ConclusionsThis study assesses the use of the MYMOP2 and W-BQ12 questionnaires ... problem specificquestionnaire which requires the respondent to specifyone or two symptoms which are concerning them most and which they are seeking treatment for. A daily activity that is being restricted...
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Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"
... them to go on the roads and try toget [to clinic]. The risks to personal safety were seen to vary based on the fam-ilies' tribal affiliation, their location, and whether they were in the ... There was one boy who was being taken care of by the uncle. They stay in Langas. Langas was, let me say, it was the heat of the violence there. This boy is on second linemedication, and at the ... go backto the house to pick the medication and there was no wayhe could come to the hospital to pick the medication. And on his way to home, he found dead bodies on the way. Fur-thermore, he...
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Báo cáo y học: "Evaluation of the Prevalence of Concomitant Idiopathic Cyclic Edema and Cellulit"
... in regional lymphostasis in the skin which impedes the mobilization of these substances leading to their accumulation. Among the factors that affect this system are female hormones and genetic ... based on the clinical severity. Grade I is characterized by smooth skin without any dimpling upon standing and laying down, but the skin adopts a mattress-like (orange peel) configuration upon ... in obesity and in other evident causes of clinical edema. The diagnosis of idiopathic cyclic edema was clinical based on the clinical history and fluid reten-tion throughout the day and, in...
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Báo cáo y học: "Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-Based Monomers"
... restricting the ligation efficiency. The ligation starts with the chemical reaction of the Reppe Anhydride derivative monomer 3, the reaction partner with the higher reactivity. After completion, the ... second ligation reaction with the pentenoic acid 2 begins. The process of the chemical reaction can be monitored by the colour change and the end of the reaction is indicated by decolorization ... developed monomers based on the peptide nucleic acid’s (PNA) polyamide backbone [8], mimicking exactly the Wat-son-Crick hydrogen-bond formation [9-14]. The func-tionalization of the “PNA”...
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Báo cáo y học: "Relationship between Anti-CCP Antibodies and Oxidant and Anti-Oxidant Activity in Patients with Rheumatoid Arthrit"
... Fethi Ceylan3 1. Yuzuncu Yil University, Medical Faculty, Department of Physical Medicine Rehabilitation and Rheumatology, Van, Turkey; 2. Yuzuncu Yil University, Medical Faculty, Department ... phosphory-lation and repetitive cycles of hypoxia and reoxygen-ation, along with oxidants produced by phagocytic cells such as macrophages and neutrophils, lead to chronic oxidative stress in the ... (CAT) analysis CAT (EC 1.11.1.6) activity was determined by the method of Aebi [16]. The principle of the assay is based on the determination of the rate constant (s−1, k) of the H2O2...
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Báo cáo y học: " Efficacy of the Valsalva Maneuver on Needle Projection Pain and Hemodynamic Responses During Spinal Puncture"
... orally on the morning of surgery. On arrival in the operating room, ECG electrodes and non-invasive blood pressure (NIBP) monitor were applied and oxygen saturation was monitored by pulse oxymeter. ... effi-cacy of balloon inflation on venipuncture pain in pe-diatric and adult patients. In a study by Gupta et al on seventy-five pediat-ric patients aged 6–12 yr, the efficacy of balloon infla-tion ... Abstract This study evaluated the efficacy of the valsalva maneuver that can induce baroreceptor ac-tivation and nociception, on needle projection pain and hemodynamic responses associated with...
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Báo cáo y học: "Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistyr"
... of the PNA back-bone monomer using the fluorenylmethoxycarbonyl (Fmoc) protection occurred as described by Atherton and Sheppard.[40] Synthesis of the Fmoc-C2-glycine-tert-butyl ester The ... stirring constantly. In the process the reaction solutions colour changes to yellowish. The reaction batch was stirred continuously over night and concentrated by the rotary evaporator. The yellow ... night and the reaction’s completeness was checked by thin layer chromatography. The reaction prod-uct was inspissated by the rotary evaporator and consecu-tively und covered with ether. The...
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Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. CYP3A5 polymorphisms seem to affect tacrolimus kinetics at a greater degree com-pared to CYP3A4 ones and thereby, these polymor-phisms ... transporters and the metabolizing en-zymes [7,9]. CYP3A, the primary subfamily of the cytoch-rome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus [10]. Specifically; tacro-limus ... deficiency (years) 38/24-50 Age at the onset of the chronic renal deficiency for females (years) 36/29-49 Age at the onset of the chronic renal deficiency for males (years) 38/23-50 Primary...
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