... safe agents for the prevention and treatment of cancer remains inefficient and costly, and falls short of the requirements for primary prevention among the high-risk population and for prevention ... Department of Health Risk Analysis and Toxicology, Maastricht University, the NetherlandsColorectal cancer is the third most commonly diagnosedcancer in the world and is one of the major causes of cancer-associated ... to the epithelial cells in the intestinal wall,where procyanidins and other phenolics are extensivelydegraded, metabolized and absorbed. In a first stage, the oligomers are depolymerized and the...