Báo cáo Y học: Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? ppt

... of eIF4E phosphorylation in mRNA translation, bearing in mind that the main mechanism governing the actual availability of eIF4E for translation is not its phosphorylation (which probably does ... formation[4,6,7]. Phosphorylation of 4E-BP1 is blocked by rapamy-cin, which inhibits the mTOR (mammalian target of rapamycin) signalling pathway (see accompanying reviewby Proud [1]). Rapamycin ... trans-lation across the board of mRNAs that are already activelybeing translated.How could increased phosphorylation of eIF4E actuallyinhibit cap-dependent translation, as observed by Knaufet al....

Tài liệu Báo cáo Y học: Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin pdf

... Iand IV and the appearance of fragment II in the degradation of the Tyr146!His/Asn147!Ser mutant (panel d)indicated a signiﬁcant decrease in the rate of cleavage of the autolysis loop. At the ... not change the catalytic activity of D-chymotrypsin. Molecular stability was determined bymeasuring heat inactivation, which was found to be a sensitive marker of the stability of chymotrypsin[13,22– ... D-chymotrypsin to tryptic cleavage was the same as seenfrom their inactivation rates in the presence of equimolaramounts of trypsin (Table 2). The cleavage of the interdomain and autolysis loopsTo...

Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx

... purity assessed by a MALDI-TOF analysis using a Hewlett Packard G202 5A LD-TOF system mass spectro-meter and a- cyano-4-hydroxycinnamic acid as matrix.Sample preparationIt has been shown that a ... stronglyhydrophobic side chains; this feature has been aptlydescribed by Rajan et al. as a Teflon coating that cansurround a helix [16] in the case of a mixture of water andhexafluoroacetone hydrate, ... ellipticity increases with the water concentration,reaching a plateau at approximately 20% water. Corres-pondingly, the helix content, as estimated by standard linearcombination fits of the spectra...

Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"

... Place, Saskatoon, SK S7N 5C9, Canada 2. Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK S7N 5E3, Canada 3. Saskatchewan Structural Sciences ... types of cancer, and evaluated the anticancer activity of the PR domain against human hepatoma HuH7 cells through both direct administration of recombi-nant His6-tagged PR and cDNA transfection. ... spreads to other organs at late stages, we speculated that RIZ1 might play an important role in tumor metastasis, although increases in mRNA expression do not al-ways translate proportionally...

Báo cáo y học: " Experimental ablation of the pancreas with high intensity focused ultrasound (HIFU) in a porcine model"

... control, the imaging probe was placed either against the skin or at a distance from the skin in water for pre-treatment imaging. The inte -grated transducer was mounted in a degassed water reservoir ... energy and pancreas histol-ogy, a preclinical in vivo study was conducted in swine demons t rat ing the feasibility and safety of HIFU for pancreas ablation [13]. In the present study, w e a i ... enzymes, and then prevents pancreatitis [24, 25]. I n our study, light microscopy displayed abundant va-cuoles of various sizes in the cytoplasm and chroma-tin margins and karyopyknosis in...

Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx

... lipase activity and a normalesterase activity, displays a substantial conformationalchange in the substrate-binding site in the C-terminaldomain (red arrow). Modeling of the K41 4A mutant,which ... N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the other face each other, thereby bringing together the substrate-binding and catalytic functions in ... domain (40% similarity) and are28% identical in the C-terminal domain (38% similarity). The catalytic efﬁciency and heparin-binding functions of the N-terminal domain have been extensively studied[13,14]....

Tài liệu Báo cáo Y học: Solution structure of the mEGF/TGFa44250 chimeric growth factor doc

... reﬂects any uncertainty in the calibration as well as alternative ﬁts to the set of distances. The main advantages of the procedure are simple: the details of the calibration are precisely and unambiguously ... relaxation rates. These valuesmay be replaced by scaled experimental values and the logarithm of the matrix may be taken to obtain distances thattake account of spin diffusion [47,48]. Typically, ... in the starting structure. Although mathemat-ical convergence may be achieved by iterative calculations, the accuracy of the distances obtained remains uncertain.Therefore, we use relaxation...

Tài liệu Báo cáo Y học: EPR characterization of the mononuclear Cu-containing Aspergillus japonicus quercetin 2,3-dioxygenase reveals dramatic changes upon anaerobic binding of substrates potx

... interpretation, the relative intensities of thetwoformsintheX-raystructureandtheEPRspectraagree, we are aware that a number of factors may in uencethese ratios: differences in pH and physical state ... addition of a flavone (apigenin), of a flavanonol (taxifolin) and of a flavan-3-ol (epicatechin)(Fig. 8) did not alter the EPR spectra of the enzymeindicating the absence of binding to the copper ... example, the gzzand gyyvalues are much closer to each other,indicating a substantial perturbation of the axial symmetry of the tensor, whereas axial symmetry, i.e. gxx% gyy<< gzzis typically...

Báo cáo Y học: Subsite mapping of the binding region of a-amylases with a computer program ppt

... units;pNP, 4-nitrophenyl group; PPA, porcine pancreatic a- amylase.Enzymes: a- amylase (EC 3.2.1.1); porcine pancreatic a- amylase(AMYP_PIG); barley a- amylase (AMY2_HORVU); rice a- amylase.(Received ... barley a- amylase isoenzyme. The binding a nities were calculated according to the data of Table 2.Fig. 6. Subsite map of rice a- amylase isoenzyme (AMY3D). The binding a nities were calculated ... is aneffective way to explore the nature of the binding site and the process of catalysis for a- amylases. Although the overallstructure and the tertiary folding of the polypeptide chainsof...

Báo cáo Y học: Functional reconstitution of the HIV receptors CCR5 and CD4 in liposomes pot

... produced the protein in mammalian cells. In orderto facilitate the proteins’ purification, a recombinant versionwas made containing a C-terminal myc tag followed by a His6sequence, by cloning the ... liposome.Reconstitution of membrane proteins allows the study of their behaviour in a membrane in the absence of otherproteins, and the manipulation of their concentration andenvironment. Unfortunately, no single ... unidentifiable by autoradiography in celllysates, but appeared as the predominant band afterpurification, although a background of contamination byother proteins was still present. The second...

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