... [67].MEK inhibitors alone tend to cause only modest cell death in CML cells, but PD184352 can act synergisti-cally with imatinib or dasatinib in BCR–ABL+cells,leading to a substantial increase in ... cells represses BIM and allows interleukin-3–independent survival; treatment ofthese cells with imatinib reverses the effects of BCR–ABL, resulting in increased expression of BIM and cell death ... however, in viable cells, BAX and BAK are restrained by theirinteraction with the prosurvival proteins such asBCL-2, B -cell lymphoma-extra large (BCL-x L ) or mye-loid cell leukaemia 1 (MCL-1)....