... discovered in BE and EAC, including frequent gain of chromosomes 6p (1 0–3 7%), 7q (1 7–3 7%), 7p (3 0–6 0%), 8q (5 0–8 0%), 10q (2 0–5 0%), 15q (1 0– 40%), 17q (3 0–5 0%), and 20q (5 0–8 0%); and frequent ... Proteins involves in the other pathways Except to signaling pathways mentioned above, there are other key proteins were also involved in esophageal carcinogenesis. Short survival and disappointing ... to invasive cancer reflect the cell defense effort in maintaining intracellular homeostasis. Interestingly, a minor down-regulation of PRX2 isoform was detected in ESCC [23,24] suggesting...