Báo cáo khoa học: Solution structure of Cu6 metallothionein from the fungus Neurospora crassa pptx
Báo cáo khoa học: Solution structure of Cu6 metallothionein from the fungus Neurospora crassa pptx
... [5–8].Since the MTs have little or no repetitive secondary structure, their tertiary structure is dependent on the number and type of metal ions they coordinate. The MT from the fungus Neurospora crassa, isasingledomain ... Determining the deviation of the generated structure with a reducednumber of NOEs from the published MT1 structure provides a measure of accuracy shown in Fig. 4B. As canbe seen, the structure of MT1 ... had inhibited its structure elucidation. A hallmark of the MT structures is the dependence on the sequential position of the cysteine in the primary sequence, the identity of the coordinated metal...
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Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx
... mecha-nism of transphosphorylation, which implies the ABFig. 3. Stereo diagram of the active center of HtA. (A) Superposition of the active-siteresidues of the 20 conformers of the solu-tion structure ... electrostatically with the othercharged groups. In the NMR structures, this sidechain of D40 is a short distance (£ 3A˚) from the sidechains of H42 and R95. Finally, the aromatic ring of F126, placed ... second-ary structure elements. As in other ribotoxins, theseABCFig. 2. Representation of the 3D structure of HtA in solution. (A) Superposition of the 20 best structures obtained in this work(PDB...
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Tài liệu Báo cáo khoa học: Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom docx
... fact, in the structures of Crt, the side-chain of Phe 25 is close enough to the amide proton of Lys38 to induce a ring current effect.Description of the toxin structure and potential surface The ... reported in Fig. 3A,and the analysis of the / and w angle distribution allowed the identification of the type and boundaries of the secondary structure elements. Crt consists of three antiparal-lel ... )1topology [47] of the triple-stranded antiparallel b-sheet wasFig. 3. Summary of data used in the determination of the secondary structure of crotamine. (A) Primary sequence of Crt with the sequential...
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Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt
... [15]. The solution structure of the MBD of rat (r)MeCP2 hasrecently been determined [17]. The MBD adopts a wedge-shaped structure, composed of an antiparallel b-sheet onone face of the wedge ... [18]. The structure of the helicalcoil a2/a3allows us to interpret the consequences of the six mutations. As P153(152) and G162(161) are buried in the protein core, replacement of each of these ... cluster in these two regions. Know-ledge of the structure of a larger portion of MeCP2including the transcriptional repression domain wouldresolve these speculations and clarify the role of the helical...
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Báo cáo khoa học: Solution structure of the catalytic domain of RICH protein from goldfish pot
... similarity of the structures. The lowest-energy structure from the RICH NMR ensemble is used for the overlay. (D) The surface of the RICH catalytic domain shows several negatively charged patches of ... regrowthupon the optic nerve crush, and also expressed in the germinal neuroepithelium of retina, which generatesnew neurons throughout the lifespan of the fish [11]. The cloning of the RICH proteins from ... et al. Solution structure of the RICH catalytic domainFEBS Journal 274 (2007) 1600–1609 ª 2007 The Authors Journal compilation ª 2007 FEBS 1609 Solution structure of the catalytic domain of RICH...
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Báo cáo khoa học: Solution structure of the active-centre mutant I14A of the histidinecontaining phosphocarrier protein from Staphylococcus carnosus ppt
... towards the interior of the protein. The space that in the wild-typemolecule is occupied by the large hydrophobic side chain of Fig. 3. Structure ensemble of HPr(I14A). The average structure of the 10 ... wascomputed as the ratio of the s tandard deviations of the chemical shifts of the amide nitrogen and p roton nuclei.ResultsDetermination of the three-dimensional structure of HPr(I14A)To allow the comparison ... which the absolute value of the difference in dihedral angles exceeds the sum of the errors.Ó FEBS 2004 Solution structure of the I14A mutant of HPr (Eur. J. Biochem. 271) 4821Our data provide the...
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Báo cáo khoa học: Solution structure of the bb¢ domains of human protein disulfide isomerase docx
... relativeorientations of the a and b domains. In one struc-ture, the catalytic cysteines face each other; in the other, the catalytic residues of the a domain faceaway from the a¢ domain. The crystal structures ... mm of monomers at 30 °C. Most of the 1H-15N HSQC signals of the dimeric form of PDI-bb¢ coincide with the signals of the monomeric form or are weak as a result of the high molecular weight of ... 12.1).Superimposition of these structures is shown inFig. 3C. The differences could result from (a) an effect of the second b domain in our PDI-bb¢ structure, (b) the I289A mutation, or (c) the presence of the...
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Báo cáo khoa học: Solution structure of 2¢,5¢ d(G4C4) Relevance to topological restrictions and nature’s choice of phosphodiester links docx
... espectively.On the other hand, slide for the GC pair at the GC step thatlinks the G stretch with the C stretch is rather high()3.3 2 A˚). The nature of the base stacking interaction in the isod(GGGGCCCC) ... comprehensiveunderstanding of the stereochemistry that govern the structures of 2 ¢,5¢ nucleic acids, we recently reported the Fig. 5. Stereo plot of the average structure of is o d(G4C4). (A) ... [44]. These clearly point to the constrainton the r ange of duplex helical structures possible for nucleicacids with 2¢,5¢ linkages. The lateral slide of the sugar-phosphate chain from the periphery...
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Báo cáo khoa học: Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy pot
... although the length of loop I is longer in short neurotoxins.TheNMRstructureofNTX-1isclosesttothatofthea-cobratoxin crystal. The superposition of these twostructures shows an RMSD value of 3.00 ... of the X-ray structure can be observed in the NMRstructures but the length of the b-strand in loop I in solution is somewhat shorter than that of the crystal one(Fig. 6A,B). The presence of an additional ... residues in the binding of a-CTX to the muscular receptor is remarkableFig. 3. The ensemble of 20 s uperimposedstructures. A stereoview of the molecules isillustrated; all of the structures...
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Báo cáo khoa học: Solution structure of human proinsulin C-peptide ppt
... Together with the 3JNHacouplingconstants and the secondary chemical shifts (Fig. 2A), the NOE pattern characterizes the local structure of the peptide. As already mentioned, the analysis of the chemical ... and by the random /,w-angle distribution in the Ramachan-dran plot of the experimental structures. The unambig-uous absence of an NOE between the Haproton of Asp4 and the HNproton of Val7 ... removal of the C-terminal argi-nines from the B-chain of insulin is essential for the interaction of mature insulin with its receptor [2]. How-ever, the processing of the C-peptide is rather curious...
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Từ khóa: Nghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDENghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngBT Tieng anh 6 UNIT 2Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Trách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)BÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ