... molecules,including cyclins, cyclin-dependent kinases, their inhib-itors and the retinoblastoma protein (RB), as well asE2Fs.E2F and RB family members appear to participate in the regulation of cell-cycle ... December2010)doi:10.1111/j.1742-4658.2010.07980.x The escalating prevalence of obesity is one of the most pressing healthconcerns of the modern era, yet existing medicines to combat this globalpandemic are disappointingly limited in terms ... cyclin ⁄ cyclin-dependentkinase holoenzymes, releasing the E2F complex andthereby resulting in activation of the E2F target genes[9]. Fajas et al. [10] demonstrated that the E2F proteinfamily...