Báo cáo khóa học: Genetic defects in fatty acid b-oxidation and acyl-CoA dehydrogenases Molecular pathogenesis and genotype–phenotype relationships ppt

... the world for providing genetic and cell material for the studies and certain of them for inspiringdiscussions concerning genotype–phenotype interactions in especiallythe acyl-CoA dehydrogenase ... short-chain acyl-CoA dehydrogenase gene. Mamm. Genome 8, 922–926.482 N. Gregersen et al. (Eur. J. Biochem. 271) Ó FEBS 2004MINIREVIEW Genetic defects in fatty acid b-oxidation and acyl-CoA dehydrogenases Molecular ... Sciences and 2Institute of Human Genetics,Aarhus University, Aarhus, DenmarkMitochondrial fatty acid oxidation deﬁciencies are due to genetic defects in enzymes of fatty acid b-oxidation and transport...

Báo cáo khoa học: Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone pdf

... Jarai,Z.,Fezza,F.,Miura,G.I.,Palmiter,R.D.,Sugiura,T.&Kunos,G. (2001) Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410, 822–825.11. Harvey, J . & Ashford, M.L. (2003) Leptin in the CNS: much morethan ... mML-glutamine and 1% nonessential amino acids [18]. BothCHP100 and U937 cells were maintained at 37 °Cinhumidiﬁed 5% CO2atmosphere. Incubation of U937 orCHP100 cells with leptin, alone or in the ... food intake and energy expenditure in mammals, including regulation offertility [ 2] and modulation of immune response [ 3]. Thesetwo actions might be interconnected in humans becauseleptin...

Báo cáo khoa học: Escherichia coli cyclopropane fatty acid synthase Mechanistic and site-directed mutagenetic studies potx

... containing an engin-eered ribosome binding site [31] and a His6-tag wasconstructed using PCR-based recombinant technology and cloned into a pET-24(+) vector. A C-terminal taggedprotein was ... monomer were titrated in onehour with triphasic kinetics. Three cysteines reacted within4 min, two more cysteines reacted more slowly within40min,andonecysteinereactedinathirdveryslowphase.If ... B.M. & Liu, H W. (2003) Cyclopropane fatty acid synth ase from Es cherichia coli. Enzyme p uriﬁcation and inhibition by vinylﬂuorine and epoxide-containing substrate ana-logues. Chembiochem....

Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx

... Similarities in the biosynthesis pathway of legionaminic acid and neuram-inic acid (5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid) have been described previously [17]. In strainsbelonging ... (N-acetyl-D-glucosamine); QuiNAc, 2-acetamido-2,6-dideoxy-D-glucose (N-acetyl-D-quinovosamine); Rha,L-rhamnose; Leg and 4e -Leg,derivatives of legionaminic and 4-epilegionaminic acid, respectively. ... also found in the OPS from strain Philadelphia 1, in which their1H NMR chemical shifts are in uenced by8-O-acetylation of the N-methylated legionaminic acid residue [12]. Interestingly, the...

Báo cáo khoa học: Structural ﬂexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics pdf

... lysines in both cases), selective inhibitors againstaldolase [24] and phosphofructokinase [25] have beendeveloped. Despite bearing chemically reactive groups,by combining high afﬁnity and ... form, including one containing a novelmetal binding site. Furthermore, they show structuralheterogeneity in their inhibitor-bound forms, highlight-ing the potential to extend future inhibitors ... residues (Thr41 and Gly42) in the sulfate_1 structure, leaving only the gap in loop 3from Thr260-Pro266. The sulfate_1 and sulfate_2 structuresare similar overall and in the vicinity enabling a simplesplicing...

Báo cáo khoa học: Mitochondrial biogenesis in mtDNA-depleted cells involves a Ca2+-dependent pathway and a reduced mitochondrial protein import pdf

... behavior and geneexpression can be observed depending on mtDNA defects. Indeed, in rho-cells, Tom20 and Tim23 proteinlevels were reduced whereas mtHSP70 was induced,leading to a small increase in ... transcript encoding the b-subunit of the Fo-F1-ATPase, Tim44 and COXVb was determined by real-timePCR using SYBR green staining and normalized for TBP (TATA-box binding protein) used as a reference ... protein import driving forces are decreased in mtDNA-depleted cells. (A) ATP content was measured in the var-ious cell lines using a luciferin-luciferase assay and results calcula-ted in RLU...

Báo cáo khoa học: "Predicting Barge-in Utterance Errors by using Implicitly Supervised ASR Accuracy and Barge-in Rate per User" pot

... wayof improving performance. In another aspect in dialogue systems, cer-tain dialogue patterns indicate that ASR results in certain positions are reliable. For exam-ple, Sudoh and Nakano (2005) ... correctly interpreted or not byintegrating the user’s current ASR accuracy and barge -in rate.2.2 Estimating ASR Accuracy by usingImplicitly Supervised LabelsTo perform runtime prediction, we use informa-tion ... containing incorrect content and instead repeat their original utterances. Con-sequently, we regard that the ASR results of thefollowing utterances are correct: (1) afﬁrmativeresponses and...

Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx

... kinase 2 (LRRK2) and ATP13A2. Mutations in the genes encoding a-synuclein, LRRK2 and ATP13A2cause autosomal-dominant forms of parkinsonism.Mutations in the genes encoding Parkin, DJ-1 and PINK1 ... kinasesincluding casein kinase 1, protein kinase A, proteinkinase C [86] and cyclin-dependant kinase 5 [87]. Phos-phorylation of Parkin by CDK5 may regulate its ubiqu-itin-ligase activity and therefore ... pool of PINK1 has beendescribed [16,17]. PINK1 is of great interest toresearch into mitochondrial dysfunction in PD. PINK1contains a putative catalytic serine–threonine kinasedomain and shares...

Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

... substantia nigra. In addition,typical PD cases have intracellular proteinaceous inclu-sions called Lewy bodies and Lewy neurites in thebrainstem and cortical areas. Genetic research in the past ... MINIREVIEWEmerging pathways in genetic Parkinson’s disease:Potential role of ceramide metabolism in Lewy body diseaseJose Bras1,2, Andrew Singleton1, Mark R. Cookson3 and John ... supplied by cranial nerves,resulting in difﬁculties in articulation and swallowing.Mental deterioration and epilepsy occur in some.Onset is in the ﬁrst or second decade and death usu-ally occurs...

Báo cáo khoa học: Deﬁciency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice pot

... P(1984) Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. J Clin Invest 73, 1367–1376.31 Voshol PJ, Rensen PC, ... toNAFLD. In vitro and in vivo studies have shown that lipopro-tein-bound apoE is the natural ligand for LDLr[26,32], which is the main receptor involved in theclearance of apoE-containing lipoproteins ... Italy) for theindicated period, and the body weights and fasting plasmacholesterol and triglyceride levels were determined at theindicated time points after diet initiation. The standard wes-tern-type...

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