... ª 2008 The Authors Journal compilation ª 2008 FEBS
MINIREVIEW
Huntington’s disease: revisiting the aggregation
hypothesis in polyglutamine neurodegenerative diseases
Ray Truant, Randy Singh Atwal, ... 2008)
doi:10.1111/j.1742-4658.2008.06561.x
After the successful cloning of the first gene for a polyglutamine disease in
1991, the expanded polyglutamine tract...
... Trehalose increased autophagic flux in various
cell lines, thereby enhancing the clearance of mutant
huntingtin and a-synuclein mutants and reducing the
toxicity of these mutant proteins. Furthermore, ... translated into an expanded polygluta-
mine tract in the N-terminus of the huntingtin protein.
Mutant huntingtin toxicity is believed to be expressed
after it is cleaved to form N...
... clathrin light chain B; ENTH, Epsin N-terminal homology; HD, Huntington’s disease; HIP-1, huntingtin-interacting protein 1; HIPPI,
huntingtin-interacting protein 1 interactor; Htt, huntingtin protein; ... Htt is involved
in various cellular processes and that the mutated Htt alters these processes
in HD. The roles of these interacting proteins in HD pathogenesis remain
largely unk...
... transformed into the E. coli S17-1(kpir)
strain, and then conjugated into the T. roseopersicina
GB2131 strain as described previously [27]. The single
recombinants selected through their kanamycin resistance
were ... expression of the Hup enzyme depends on
the thiosulfate content of the medium
With a view to examining the function of the HupC
protein in T. roseopersicina,aDh...
... dopamine neurons
in the substantia nigra (SN) causes the major PD
symptoms, but there is often widespread neurodegener-
ation and pathology in other regions of the brain,
including the proteinaceous ... kinase 2
(LRRK2), Parkin, DJ-1 and PTEN-induced kinase 1 (PINK1), many of
them coding for proteins found in LBs and ⁄ or implicated in mitochondrial
function. However, the me...
... ischemia. The results of
these studies have been rather conflicting in supporting either a beneficial
or a detrimental role for the endocannabinoid system in post-ischemic neu-
ronal death, in that ... dissecting the role of the endocannabi-
noid system in physiology as well as in pathological
processes. The system incorporates the endocannabi-
noids, their synthetic and d...
... sensing [2]. In
addition to the N-terminal input domain, SKs contain
a C-terminal portion representing the transmitter mod-
ule, with several blocks of amino acid residues being
conserved among these ... heme-
binding protein [16]. Physiologic studies showed that
the production of HbpS is positively in uenced by
hemin in S. reticuli; this correlated with increased
hemin resistance....
... level. On the other hand,
the 5¢-UTR enhanced recombinant protein expression
in the MSG cells at the level of translation, leading to
a 1.5-fold increase in recombinant protein synthesis.
In the present ... produced by these
silkworms exhibited the properties of both the silk and
the recombinant proteins because the recombinant pro-
teins were embedded in the fibroi...
... document, individually.
There is no interaction at the corpus level.
Determining the multi-grained sequences to
be aligned
First, we consider the two languages of the
document independently, the ... sequence in L1 has many
chances to be translated by the same sequence in
L2 in the same text. This hypothesis holds inside
the document but not in the corpus: a...
... increasing amounts of unlabelled MW
prior to cross-linking. As shown in Fig. 2(A), increas-
ing amounts of unlabelled MW reduced the binding
of RNA to the 36 kDa protein such that binding was
reduced ... to bind to c-myc transcripts in vitro.
The c-myc transcripts corresponding to either exon 3
(which contains both coding and 3¢UTR regions), the
3¢UTR or the region of the 5¢UT...