Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases pptx

Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases pptx

Báo cáo khoa học: Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases pptx

... ª 2008 The Authors Journal compilation ª 2008 FEBS MINIREVIEW Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases Ray Truant, Randy Singh Atwal, ... 2008) doi:10.1111/j.1742-4658.2008.06561.x After the successful cloning of the first gene for a polyglutamine disease in 1991, the expanded polyglutamine tract...
Ngày tải lên : 23/03/2014, 07:20
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Báo cáo khoa học: Huntington’s disease: degradation of mutant huntingtin by autophagy doc

Báo cáo khoa học: Huntington’s disease: degradation of mutant huntingtin by autophagy doc

... Trehalose increased autophagic flux in various cell lines, thereby enhancing the clearance of mutant huntingtin and a-synuclein mutants and reducing the toxicity of these mutant proteins. Furthermore, ... translated into an expanded polygluta- mine tract in the N-terminus of the huntingtin protein. Mutant huntingtin toxicity is believed to be expressed after it is cleaved to form N...
Ngày tải lên : 23/03/2014, 07:20
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

... clathrin light chain B; ENTH, Epsin N-terminal homology; HD, Huntington’s disease; HIP-1, huntingtin-interacting protein 1; HIPPI, huntingtin-interacting protein 1 interactor; Htt, huntingtin protein; ... Htt is involved in various cellular processes and that the mutated Htt alters these processes in HD. The roles of these interacting proteins in HD pathogenesis remain largely unk...
Ngày tải lên : 23/03/2014, 07:20
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Báo cáo khoa học: Electron-transfer subunits of the NiFe hydrogenases in Thiocapsa roseopersicina BBS pptx

Báo cáo khoa học: Electron-transfer subunits of the NiFe hydrogenases in Thiocapsa roseopersicina BBS pptx

... transformed into the E. coli S17-1(kpir) strain, and then conjugated into the T. roseopersicina GB2131 strain as described previously [27]. The single recombinants selected through their kanamycin resistance were ... expression of the Hup enzyme depends on the thiosulfate content of the medium With a view to examining the function of the HupC protein in T. roseopersicina,aDh...
Ngày tải lên : 16/03/2014, 03:20
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Báo cáo khoa học: Parkinson’s disease: genetic versus toxin-induced rodent models pot

Báo cáo khoa học: Parkinson’s disease: genetic versus toxin-induced rodent models pot

... dopamine neurons in the substantia nigra (SN) causes the major PD symptoms, but there is often widespread neurodegener- ation and pathology in other regions of the brain, including the proteinaceous ... kinase 2 (LRRK2), Parkin, DJ-1 and PTEN-induced kinase 1 (PINK1), many of them coding for proteins found in LBs and ⁄ or implicated in mitochondrial function. However, the me...
Ngày tải lên : 07/03/2014, 05:20
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Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt

Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt

... ischemia. The results of these studies have been rather conflicting in supporting either a beneficial or a detrimental role for the endocannabinoid system in post-ischemic neu- ronal death, in that ... dissecting the role of the endocannabi- noid system in physiology as well as in pathological processes. The system incorporates the endocannabi- noids, their synthetic and d...
Ngày tải lên : 07/03/2014, 03:20
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Báo cáo khoa học: DNA-binding characteristics of the regulator SenR in response to phosphorylation by the sensor histidine autokinase SenS from Streptomyces reticuli doc

Báo cáo khoa học: DNA-binding characteristics of the regulator SenR in response to phosphorylation by the sensor histidine autokinase SenS from Streptomyces reticuli doc

... sensing [2]. In addition to the N-terminal input domain, SKs contain a C-terminal portion representing the transmitter mod- ule, with several blocks of amino acid residues being conserved among these ... heme- binding protein [16]. Physiologic studies showed that the production of HbpS is positively in uenced by hemin in S. reticuli; this correlated with increased hemin resistance....
Ngày tải lên : 07/03/2014, 10:20
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Báo cáo khoa học: Production of a recombinant mouse monoclonal antibody in transgenic silkworm cocoons pptx

Báo cáo khoa học: Production of a recombinant mouse monoclonal antibody in transgenic silkworm cocoons pptx

... level. On the other hand, the 5¢-UTR enhanced recombinant protein expression in the MSG cells at the level of translation, leading to a 1.5-fold increase in recombinant protein synthesis. In the present ... produced by these silkworms exhibited the properties of both the silk and the recombinant proteins because the recombinant pro- teins were embedded in the fibroi...
Ngày tải lên : 23/03/2014, 04:20
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Báo cáo khoa học: "Multilingual Lexical Database Generation from parallel texts in 20 European languages" pptx

Báo cáo khoa học: "Multilingual Lexical Database Generation from parallel texts in 20 European languages" pptx

... document, individually. There is no interaction at the corpus level. Determining the multi-grained sequences to be aligned First, we consider the two languages of the document independently, the ... sequence in L1 has many chances to be translated by the same sequence in L2 in the same text. This hypothesis holds inside the document but not in the corpus: a...
Ngày tải lên : 23/03/2014, 18:20
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Báo cáo khoa học: Annexin A2 binds to the localization signal in the 3¢ untranslated region of c-myc mRNA ppt

Báo cáo khoa học: Annexin A2 binds to the localization signal in the 3¢ untranslated region of c-myc mRNA ppt

... increasing amounts of unlabelled MW prior to cross-linking. As shown in Fig. 2(A), increas- ing amounts of unlabelled MW reduced the binding of RNA to the 36 kDa protein such that binding was reduced ... to bind to c-myc transcripts in vitro. The c-myc transcripts corresponding to either exon 3 (which contains both coding and 3¢UTR regions), the 3¢UTR or the region of the 5¢UT...
Ngày tải lên : 30/03/2014, 15:20
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