Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome docx
Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome docx
... FEBS 29 55 Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20 S proteasome Gustavo M. Silva1 ,2 , Luis E.S. Netto 2 , Karen F. Discola 2 , Gilberto M. ... SG (20 01) Inactivation of humanG. M. Silva et al. Cysteinyl-based modification of the 20 S proteasome FEBS Journal 27 5 (20 08) 29 42 29 55 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 29 53peroxiredoxin ... corre-sponding author for the article.G. M. Silva et al. Cysteinyl-based modification of the 20 S proteasome FEBS Journal 27 5 (20 08) 29 42 29 55 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 29 55Role...
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Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot
... impor-tant roles in maintaining immune homeostasis and pre-venting autoimmunity. These regulatory cells caneither develop in the thymus or differentiate in the periphery. The central role of cytokines ... IFN-Fig. 2. Itk in uences the balance of conven-tional and innate T-cell lineages. In the absence of Itk, there is a reduction of con-ventional CD4+ and CD8+cells and anexpansion of innate ... remains to be understood on the gen-eration of innate T-cell populations, it is intriguingthat both in the periphery and in the developing thy-mus, Itk plays a major role in the regulation of...
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Báo cáo khoa học: Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts docx
... membrane maintains the cytosolic and mitochondrial compartments in equilibrium.We were interested in investigating whether in the fibroblasts of the two TK2 patients the operation of the network ... efficiency in Ca and Pa cells (Fig. 2A), con-firming the involvement of TK2 in the phosphorylation of thymidine in both cell lines inferred above (Table 1)from the inhibition of thymidine phosphorylation in ... 3A) and returned to the prepulse value during the 30 min chase in both control and TK2-mutatedcells in the absence of thymidine. When thymidine waspresent during the chase, the decline of the...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... previously [21 25 ], and DGD° values in the presence of these osmolytes are given in Table 1. How-ever, DGD° values of RNase-A in the presence of alanine, serine, lysine, b-alanine, taurine and dimethyl-glycine ... backbone and the osmolytes leading to the preferential hydration of the protein domain is the driving force of protein stabiliza-tion or folding [3,4]. Furthermore, the effect of osmolytes on the ... (a) the main driving force for the folding is the unfavourableinteraction between the osmolyte and the peptide back-bone, and (b) the total contribution of side chains to the stability of the...
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Báo cáo khoa học: "Biographies, Bollywood, Boom-boxes and Blenders: Domain Adaptation for Sentiment Classification" potx
... and SCL-MIEach labeled dataset was split into a training set of 1600 instances and a test set of 400 instances. All the experiments use a classifier trained on the train-ing set of one domain ... bars, the first letter is the source domain and the second letter is the targetdomain. The thick horizontal bars are the accura-cies of the in- domain classifiers for these domains.Thus the first ... in both domains. In both cases, be-tween 85 and 90% of the informative features fromone domain were not among the most informative of the other domain4. SCL addresses both of theseissues...
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Báo cáo khoa học: Structural origins for selectivity and specificity in an engineered bacterial repressor–inducer pair pdf
... respect to the positioning of the ligands and the conformations of the residues lining the bindingsite (Table 2) . In an initial comparison of the ligandpositions of tetracycline, dox and atc in TetR, ... increased coordinate errorsduring the refinement of the atomic positions and hence a less accurate ligand positioning in site II.Accordingly, the description of the binding of the ligand in the present ... are the interactions between the ligand and the protein in the effector-binding site (Figs 1B and 2A). Of the two binding sites that can be observedindependently in the 4-ddma-atc-complex structure,ACBFig....
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Báo cáo khoa học: Interaction with model membranes and pore formation by human stefin B – studying the native and prefibrillar states docx
... 16.8StB-Y31 23 .7 25 .7G4R 20 .9 25 .9PrefibrillarStB-wt 25 .3 24 .5StB-Y31 24 .7 27 .0G4R 26 .7 26 .9Pore formation of stefin B into lipid membranes S. Rabzelj et al. 24 58 FEBS Journal 27 5 (20 08) 24 55 24 66 ... stefin B: in uence of pH and TFE on fibril growth and morphology. Amyloid 14, 23 7 24 7. 32 Gorbenko GP & Kinnunen PK (20 06) The role of lipid-protein interactions in amyloid-type protein fibril ... Unspecific bind-ing sites were blocked by one 1 min injection of 0.1 mgÆmL)1bovine serum albumin. For the bindingexperiment, proteins were injected at a concentration of 10–70 lm for 120 s at 20 lLÆmin)1....
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Báo cáo khoa học: Role of the structural domains in the functional properties of pancreatic lipase-related protein 2 pot
... of the active site was better in the protein bear-ing the N2 domain than in the protein bearing the Ncdomain. Thus, the accessibility of the active site in the N2 proteins was independent of ... of the water–lipid interface. Also, both the N-terminal and C-terminal domains of hoPL wereinvolved in the inactivation of the protein at the water–triglyceride interface. The inactivation of ... domains of PLRP2 in the function of the protein, two chimeric proteins were designed by swapping the N and C structural domains between the horse PL (Nc and Ccdomains) and the horse PLRP2 (N2 and...
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Báo cáo khoa học: Role of extracellular signal regulated kinases 1 and 2 in neuronal survival docx
... anti-apoptoticmembers of the bcl -2 family including bcl -2 and bag-1.For instance, the prosurvival activity of ERK1 /2 in PC 12 cells may proceed via CREB-stimulated expression of bcl -2 [40]. Furthermore, in HSV2-infected ... signalingERK1,alsoknownasp44mitogenactivatedproteinkinase(MAP kinase), and ERK2 (p 42 MAP kinase) are closelyrelated protein kinases of the MAP kinase family [3]. ERK1 /2 is regulated by a cascade of phosphorylations includinga dual ... hampered by the fact thatinhibition of one element of the ERK1 /2 signaling networkmay modulate other signaling units. For instance, selectiveinhibition of MKK1 /2 increases ERK5 activity [6]. There-fore,...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... mediator of lethal sepsis, triggering the production of proinflammatory cytokines and liverinjury [13].Therefore, the present study aimed to elucidate the role of KCs in the regulation of CYP isoform ... drug-metabolizing dysfunction during sepsisFEBS Journal 27 8 (20 11) 23 07 23 17 ª 20 11 The Authors Journal compilation ª 20 11 FEBS 23 17 Role of Kupffer cells in pathogenesis of sepsis-induceddrug metabolizing ... [22 ]. ROS indirectly reduced the activity of selected isoforms of CYP by inducing phosphorylation of the isoforms [23 ]. Activated KCs cause oxidativestress on the surrounding tissue, releasing...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật