... An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein Tomoji Maeda1, Toshihiro Marutani2,*, ... directly interacting with the sub-strate proteins and helping to transfer ubiquitin tothem. Therefore, to determine whether NCT is the substrate of Synoviolin, we determined whether Syno-violin interacts ... grant from the Ministry of Health,Labor and Welfare of Japan. We thank Dr Paul Lang-man for assistance with the English.References1 Selkoe DJ (2002) Deciphering the genesis and fate of amyloid...