Báo cáo khoa học: Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I pdf
Báo cáo khoa học: Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I pdf
... [8] indicate that its alanine-glyoxylate aminotransferase activity is not favoredover aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase activities. In the ... Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I Juan R. Herna´ndez-Fernaud1 and Eduardo Salido21 Max Planck Institute for Biochemistry, ... glycolysis and fatty acid pathways.AbbreviationsAGT1, alanine-glyoxylate aminotransferase 1; AGT2, alanine-glyoxylate aminotransferase 2; AGXT, alanine-glyoxylate aminotransferase gene;Agxt)...
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Tài liệu Báo cáo khoa học: Differential expression of duplicated LDH-A genes during temperature acclimation of weatherfish Misgurnus fossilis Functional consequences for the enzyme ppt
... b-subunitscorrespondingly translated from mRNA a ldh a and mRNAbldh a isoforms (LDH -A mRNAratios shown in the embedded histogram),assuming similar translational activity of both mRNA isoforms and ... iso-tetramers from warm and cold acclima-tions. This is in line with most of the observationssummarized in Table 1. In particular, differences in the first denaturation transition state of LDH -A (tetramer ... resistant to inactivation (pH, temperature and urea), displays a higher specific activity, a higher speci-fic heat capacity and a lower calorimetric enthalpy butthe same denaturation temperature....
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Báo cáo khoa học: Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages potx
... milligram of protein as seen in Fig. 1.Sialidase activity was also determined against mixedbovine brain gangliosides (Calbiochem, La Jolla, CA,USA) and in the absence of exogenous substrate ... 4A) . Likewise, theanti-Neu3 IgGs recognized a protein with molecularmass of 47 kDa in both monocytes and macrophages(Fig. 4B), with an increase in intensity of staining of this protein in macrophages ... observed increase in Neu1-specific RNA and in sialidase activity using4-MU-NANA, immuno-detection of Neu1 with anti-Neu1 IgGs revealed a more intense band in macro-phages than in monocytes (Fig. 4A) ....
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Báo cáo khoa học: Differential interactions of decorin and decorin mutants with type I and type VI collagens pptx
... decorin are of paramount importance in attaining and maintainingtissue integrity. In the present study we investigate the binding properties of wild -type decorin, two decorin mutants and a truncateddecorin ... [19].Previous studies indicated that biglycan interacts with type VI collagen and is involved in the o rganization of type VI collagen networks [37]. Our findings indicate that thebinding of biglycan ... c ylinder. (A) Interaction involving d imerization of decorin and binding of both collagens to the i nner surface of decorin. (B) Inter-action of type I collagen with t he inner surface of the...
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Báo cáo khoa học: The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors ppt
... ovary (CHO) K1 and human cells by a mechanism involving transcriptional activation and, also in the case of Rb, by an increase in its stability.Materials and methodsMaterialsUCN-01 was kindly ... Rb and Sp1 after CDK inhibitionby the chemical inhibitors UCN-01, roscovitine and olomoucine, and by the intrinsic inhibitor p21. As DHFRactivity is enhanced by the association between Rb and ... transcriptionalactivation of both retinoblastoma and Sp1 promoters byUCN-01 was confirmed. Bisindolylmaleimide I, at concen-trations causing a similar or higher inhibition of proteinkinase C than...
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Tài liệu Báo cáo khoa học: "Automatic Identification of Pro and Con Reasons in Online Reviews" ppt
... pro-pose a framework for automatically identifying reasons in online reviews and introduce a novel technique to automatically label training data for this task. We assume reasons in an online review ... look at how researchers in Computational Lin-guistics define an opinion for their studies. It is difficult to define what an opinion means in a computational model because of the difficulty of ... problem of opinion analysis, identify-ing reasons for opinions, especially for opinions in online product reviews. The opinion reason identification problem in online reviews seeks to answer...
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Báo cáo khoa học: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation pdf
... which can trap the initiating and ⁄ or propagating radicals to inhibit peroxidation.After the inhibition period, absorbance at 234 nmincreased fast with time upon Cu2+-initiation, indica-ting ... and GSHshow similar inhibitory activity. Figure 3 indicates theinhibition of TBARS formation by EM1, EM2 and GSH during AAPH-induced peroxidation of LDL. Itwas found that addition of EM1 inhibited ... met-enkephalin) and their derivatives (5-S-cyst-einyldopaenkephalin, 2-S-cysteinyldopaenkephalin and [d-Ala2, d-Leu5]enkephalin) have free radicals scaven-ging activities and the capacity to...
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Báo cáo khoa học: "Identification of Domain-Specific Senses in a Machine-Readable Dictionary" potx
... LinguisticsIdentification of Domain-Specific Senses in a Machine-Readable DictionaryFumiyo FukumotoInterdisciplinary Graduate School of Medicine and Engineering,Univ. of Yamanashifukumoto@yamanashi.ac.jpYoshimi ... Yamanashifukumoto@yamanashi.ac.jpYoshimi SuzukiInterdisciplinary Graduate School of Medicine and Engineering,Univ. of Yamanashiysuzuki@yamanashi.ac.jpAbstractThis paper focuses on domain-specific senses and presents ... IntroductionDomain-specific sense of a word is crucial informa-tion for many NLP tasks and their applications, suchas Word Sense Disambiguation (WSD) and Informa-tion Retrieval (IR). For example, in...
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Báo cáo khoa học: Regulated expression by PPARa and unique localization of 17b-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver pdf
... the mouse intestine and liver by administration of thePPARa agonist. The induction ratios in both tissueswere greater than 20, and the induced protein level in the intestinal mucosa was about ... Onoduka J, Homma K, Yamaguchi S,Mori M, Higashi Y, Makita M, Kinoshita T, Noda J,Itabe H et al. (2006) Long-chain fatty acids induce lipiddroplet formation in a cultured human hepatocyte in a manner ... the protein level to obtain information about its physiologicrole in the intestine and liver. For this purpose, specific antibodies against17b-HSD11 were obtained. Western blotting analysis showed...
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Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx
... regulation of cyclin A and B1 upon TSA treatment isvia diminished activity of NF-Y-associated HAT and is mediated through CCAAT motifs; further, thediminished HAT activity is mediated by ... the mitogen-activatedprotein kinase (MAPK) JNK on Ser63 and Ser73, aswell as on Thr91 or Thr93, or both, increases its trans-activating potential and DNA-binding activity bymediating its dissociation ... furthermore, the acetyl groupsmay associate with and recruit factors containingbromo-domains [12]. Many transcriptional activators orcoactivators have (or recruit) HAT activity, giving a mechanism whereby...
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