... poses interesting compu-
tational and linguistic challenges. For instance, we
need to handle the noise inherent in matching based
on acoustic similarity, because of possible varia-
504
tions in ... (SD) models and the other ob-
tained using speaker-independent (SI) models. The
speaker-independent model was trained on 85 hours
of out -of- domain general lecture material and con-...
... II
NM23-H2
5′
3′
3′
5′
OFF
ABC
E
D
5′
3′
3′
5′
OFF
Fig. 5. Cartoon showing the involvement of NM23-H2, nucleolin and a G-quadruplex- interactive compound in modulating the activation and
silencing of the NHE III
1
in ... contaminat-
ing protein that is either an accessory protein or a
minor recombinant protein [34]. Studies show that an
R88A mutation (arginine to alanine) in th...
... sentence
in those reviews collected from each domain
with the features described in Section 3.1. We
divided the data for training and testing. We then
trained our model using the training set and ... set of pro and con sentences in online
reviews using clue phrases for pros and cons in
epinions.com in order to train our system. We
applied it to label sentences both o...
... analysis of protein spots was performed by matching
corresponding spots across different gels. Each of the
matched protein spots was rechecked manually. Intensity
volumes of individual spots were ... overexpression of enolase 1
and malic enzyme 1 supports the induction of fatty
acid metabolism. The reduction in d-amino acid oxi-
dase 1 expression in the kidney proteome is inte...
... dopamine treatment, overexpres-
sion of a-synuclein significantly affected the levels of
four proteins [stathmin 1, glutathione S-transferase
(GST)p, Ran 1 binding protein and C1q binding pro-
tein], ... suggested to be linked to
early stages of PD pathogenesis [26]. Interestingly, in
our model, dopamine induces an increase of the actin
bundles regulator fascin 1 [27] and discord...
... important in minimizing the in uence of
confounding factors arising from inherent problems
associated with breeding APP transgenic mice and
maintaining stable phenotypes. We would argue that a
single ... time-consuming and greatly
in uenced by individual handlers. IntelliCages are
automated learning cages where animals carrying
transponders are housed in groups and trained in...
... contribute to in amma-
tory injury. Taurine may offer an advantage in because of it
increase the reduced L-arginine/ADMA ratio. Thus, taurine pro-
tects cells from in ammatory injury resulting from ... its interaction with NF-jB, result-
ing in reduction of the DNA binding activity of NF-jB. We
found a putative NF-jB binding site (core binding sequence
GGGACTTT) in the promoter...
... mice have an increased incidence of
systemic lupus erythematosus (SLE), with classical findings
including the presence of autoreactive antibodies and
glomerulonephritis occurring in a DNase I-level-dependent
manner; ... previously.
Proteins were determined using a protein assay kit (Bio-
Rad) with BSA as a standard. SDS/PAGE was performed
in 12.5% (w/v) gels according to the method...
... formation of quinonoid intermediates
(Scheme 1). In the holoenzymes (E) the cofactor PLP is
bound in the active site as an Ôinternal aldimineÕ with an
e-amino group of a definite lysine residue. ... groups of amino acid inhibitors mentioned above.
The interaction of
L
-phenylalanine,
L
-methionine, and
their a-deuterated analogs with TPL in D
2
O was charac-
terized by the appe...
... (yellow) and tACE (white). (A)
Binding site of CL1 in ACE2 and tACE; (B) binding site of CL2 in
ACE2 and tACE. Residue numbering for ACE2 is first. The chloride
ion is green and the zinc ion is ... the substitution of Pro407 and
Pro519 in ACE for Glu398 and Ser511 in ACE2. The
side chains of Glu398 and Ser511 project into the loca-
tion of the chloride ion-bindi...