Báo cáo khoa học: Regulatory roles of hyaluronan in health and disease ppt
Báo cáo khoa học: Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase potx
... acetylthiocholine. The rates of hydrolysis of acetylthiocholine and butyrylthiocholine(at 6 mm) by BChE were approximately 14% and 24% of the rate of hydrolysis of acetylthiocholine(at 2 mm) by AChE. In uence ... domain and the C-terminalt peptides contribute to the control of oligomerization and secretion, in a complex interplay.Origin and significance of the difference betweenthe t peptides of AChE and ... BChE contains a proline-rich peptide fromlamellipodin [14]. In conclusion, the catalytic domains of cholinesterases and their C-terminal t peptides constitute modules of quaternary interactions...
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Blue-light active flavoproteins studied by electron paramagnetic resonance pptx
... modification of the cofactor-binding site at the 8a-methyl group and at the linkage of the ribityl side chain. Hence, as a first result, struc-tural information regarding the distance and location of ... [76]: the protein consists of an a ⁄ b-domain and a FAD-binding domain. Thebinding pocket, which is smaller but deeper than those of CPD photolyases, is strictly hydrophobic and con-tains conserved ... otherproteins involved in intracellular signaling or localiza-tion [24,25]. In photolyases and cryptochromes, radicals and radical pairs play a prominent role in their function. In nearly all...
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot
... branches off in MAO A and B (Fig. 3A). The SWIRM domain is a motif com-monly found in chromatin enzymes and is responsiblefor protein–protein and DNA–protein interactions[36]. The name of this ... is in agreement with the domain organiza-tion in the first line. The third line shows a summary of the identified linear motifs (after filtering processing taking in account the accessibi-lity of ... experiments in MAO B demon-strated that these aromatic residues may have a stericrole in substrate binding and in increasing the nucleo-philicity of the substrate amine moiety [43]. In LSD1one of...
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation pptx
... protein[21–23]. The 19S caps are involved in recognition of the polyubiquitinated protein substrates, unfolding of the condemned protein [24], removing ubiquitin chainsfor recycling [25,26] and ... for sensing and binding of intrinsicallyunfolded proteins such as transcription factors. Thismechanism could be probed by combined structure–function analysis of oxidized and reduced QR and mutagenesis ... surprisingly, theenzymatic activity of the QR is also compromised in the presence of proteasome, supporting the direct orindirect involvement of the flavin cofactor in proteincomplex formation [34].α...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... thiscontext of expanded incidence and growing prevalence,clinical oncology is poised for unprecedented innova-tion. Through harnessing discoveries in disease patho-biology, increasingly propelled ... prevention,diagnosis and treatment [4–6].Indeed, the epigenetic, genetic and postgenetic cir-cuits restricting cell destiny are becoming increasinglydecoded, and their dysfunction is being linked to line-age-dependence ... MINIREVIEWA study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancerScott A. Waldman1 and Andre Terzic21 Departments of Pharmacology and Experimental...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: bioimaging of microRNA biogenesis and regulation doc
... imaging sys-tems that are used to create a better understanding of the production and function of miRNA in vivo as wellas for monitoring the therapeutic potential of miRNAs in cancer.Bioimaging ... factors, including Oct4, c-Myc and Nanog, regulate the expression of primary miRNAs bybinding them to the 5¢ terminal regulatory region of the miRNAs that participate in critical molecular and ⁄ ... forthe in vitro and in vivo investigations of miRNAproduction patterns. Second, noninvasive monitoring of miRNAs provides useful information of the possiblerole of miRNAs involving cellular developments.Third,...
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Báo cáo khoa học: Novel aspects of calmodulin target recognition and activation pptx
... for-mation with fragments of the K+-channel (c) insertion of CaM between two domains of the anthrax exotoxin (d)binding of Ca2+ions to only one EF-hand pair and (e)binding of CaM in an extended conformation ... differentCa2+-binding motifs are found in pentraxins, annexins and in C2domains [36–39]. The C2domains consist of about 130amino acids forming a compact b-sandwich composed of two four-stranded antiparallel ... peptides and charge comple-mentarity of binding surfaces determine the binding orien-tation of the peptide in complex with CaM.The second interesting feature is the conformation of theCaMKK binding...
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Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... potential of the haem, rate constants o f CO, O2 and CN b inding tohaem, and CD spectra in the Soret region [15–18],suggesting that this residue is critical for maintaining theelectronic states of ... protein.Additionally, spin states of the Fe(III), Fe(II) and Fe(II)-CO complexes of Asp40 mutants were similar tothose of the wild-type enzyme in that all mutant proteinswere in the six-coordinated ... side and/ or structure in t erms of cyanide binding in the Fe(III) complex.Redox potentialsThe redox state of haem is related to the PDE activity of Ec DOS, since it is a haem redox-sensing enzyme...
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Tài liệu Báo cáo khoa học: Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efficiency and Ca2+-sensitivity ppt
... Analysis of data wasperformed withORIGIN6.1 and SIGMA PLOT4.2 software. Adirect plot of activity vs. [GTP] gave in all cases a sigmoidalcurve indicating cooperative substrate binding. In order ... Protein samples were electrophoresed and blotted together with a sample of ROS containing 5 lg(A)or10lg(B) of rhodopsin. GCAPs in these samples were detected by specificantibodies and ECL. Band intensity ... was linear withinthe tested range, ROS with 5 lg rhodopsin contained 1.8 ng of GCAP-1 corresponding to a ratio of 1 : 1600 GCAP-1 to rhodopsin, ROSwith 15 lg rhodopsin contained 6.5 ng of GCAP-2...
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Báo cáo khoa học: Different roles of two c-tubulin isotypes in the cytoskeleton of the Antarctic ciliate Euplotes focardii Remodelling of interaction surfaces may enhance microtubule nucleation at low temperature doc
... second intronincluded nucleotides 210–253 in each gene. Excludingintrons and stop codons, the c-T1 and c-T2 codingregions were each 1383 bp in length and predictedproteins of 461 amino acids. ... nucleotide-bindingpocket of E. focardii c-tubulins are also candidatesfor adaptive compensation. Amino acid changesadjacent to the T3 loop and within the T5 loop may in uence the binding affinity and hydrolysis of ... beenobserved in E. focardii and in the psychrotolerantE. crassus [34, present study]. By contrast, the similarsubstitution of alanine for arginine 72 in the c-tubu-lins of T. thermophila and A....
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