Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute 45% of the totalunitary free energy of binding of cystatin A to cathepsin ... cathepsin B,demonstrating a major role of the second binding loop of cystatin A in the inhibition of this enzyme. Pro74 may bedirectly involved in the interaction with cathepsin B byproviding hydrophobic ... binding loop of cystatin A fulfils the same function as the second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction.To...
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Báo cáo y học: "The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study"
... identified by two or more symptomsincluding fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical ... 28-day mortality.BackgroundSepsis is a systemic inflammatory response to a confirmedor suspected infection. Clinically, the Systemic Inflamma-tory Response Syndrome (SIRS) is the occurrence of ... arrived in the ward. The nurses were aware of the study and were repeatedly reminded to obtain a full set of observations for all patients. Documentation of infectionwas based on the clinical...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... Biochem. 269) 4989 The three arabinogalactans were incubated with GALAfor 15 min, 30 min, 2 h and 20 h to determine the substrate specificity of the enzyme. The degradation of the polymer and subsequent ... Expression of lacA is also detected in the presence of these compounds, but in the presence of D-xylose and xylan as well. This can be explained by the structure of the polysaccharides. Xylan contains ... degradation of both linear and L-arabinose-substitutedgalactan side chains of pectin. This is in agreement with aprevious study in which the synergy of enzymes degrading the pectin side chains was studied...
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Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
... Y5 5¢ interacts with the phosphate moiety of PLP; E57¢ is crucial in the binding of the l-serinehydroxyl group [15] and in the catalysis of the hydrox-ymethyltransferase reaction [16]; and Y6 5¢ ... located in the central cores of the domains and presumably stabilize their scaffold, allow-ing the correct alignment of the residues involved in cofactor and substrate binding, the role of the third ... domains,respectively, and appear to stabilize their protein scaf-folds, allowing the proper positioning of the residues involved in PLP binding, substrate binding and modu-lation of the cofactor’s catalytic...
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Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc
... pathway,because of overloading of the SRP pathway. The re-routing of (G-10L)prePhoE to the Sec translocon via the SRPinstead of the SecB pathway could be explained by the increased hydrophobicity of the hydrophobic ... consists of the positively charged N domain, the hydrophobic Hdomain and the C-terminal C domain. The a-helix in the H domain is predicted to extend up to the Gly at position )10 in the signal ... commonoccurrence of a-helix-destabilizing amino acids in the hydrophobic core [28]. In a previous study, the role of the a-helix-breaking glycine residue at position )10 (Gly)10 )of the signal sequence of...
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Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"
... “Uncon-scious”,A05“Ordered mission”,A06“Inconclusive pro-blem”,A10“Chest pain” and A34/A35 “Accidents” )and one category containing the rest, called “All Other” in the analyses. In the analysis of diurnal variations, ... difficulties” was the most used Index-category in the “all other” group with nearly 5% of the total. Approximately half of all patients in the youngestage group had “all other” medical problems and convul-sions ... throughout evaluation of the Indexhas never been performed in Norway. The necessity of 39 chapters and the content of the chapters should beevaluated. The large majority of the red responseswere...
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Báo cáo y học: "The evolving story of medical emergency teams in quality improvement"
... distinct career pathway. Involving such physicians in medicalemergency teams will likely facilitate the dual roles of these as aclinical outreach arm of the intensive care unit and in identifyingproblems ... the study consisted of only a 5-minute debriefing to fill out the standardized MET form on each patient and a weekly 1-hourCommentary The evolving story of medical emergency teams in qualityimprovementAndré ... rationale for the development of METs rose from observations that, in the majority of patients, premonitory signs and symptoms of cardio-pulmonary instability are often present hours before clinicaldeterioration...
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Báo cáo y học: "The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care unit"
... revised the manuscript. HTS and FK had full access to all the study data and assume responsibility for the integrity of the data and the accuracy of the analysis.References1. Himmelstein DU, ... atinception (within the first day of ICU admission) was assessedusing the APACHE II score and intensity of care using the TISS score [15,16].Patients were classified into three categories of ... baselinecreatinine, mechanical ventilation and level of care were asso-ciated with ICU-acquired hypernatraemia.Outcomes of careLength of stay and mortality in the ICU and hospital wereincreased...
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Báo cáo y học: "The Impact of a Nationwide Antibiotic Restriction Program on Antibiotic Usage and Resistance against Nosocomial Pathogens in Turkey"
... restricted for the first three days of therapy by NARP, the consumption of these quinolones was unsurprisingly high. Besides that the use of oral quinolones for maintenance may contribute to the significant ... newspaper of the state [11]. This is a quasi-experimental study performed in four year period, which included two years before and after of the initiation of NARP in 2003. The study in- cluded the ... Materials and Methods Hospital setting and antibiotic policy: NARP was initiated in Turkey in February 2003 by a central regulation of Ministry of Health and was announced nation-wide via official...
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Báo cáo y học: "The Versatile Use of Temporoparietal Fascial Flap"
... occlusion in the drainage system. Evacuation of the hematoma and resuturing was performed. Partial skin graft losses over the flap were healed with sec-ondary epithelialization. The injury of the ... the donor site is sutured using 3/0 polypropylene. Depending on the amount of drainage, the drain is usually removed on the first or second postoperative day. An informed consent explaining ... Aesthetic Surgery, Dokuz Eylul University, Faculty of Medicine, Izmir, TURKEY. 2. Clinic of Plastic Reconstructive and Aesthetic Surgery, Public Hospital, Mus, Turkey. 3. Clinic of Plastic Reconstructive...
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