... Effect of surface concen-tration on secondary and tertiary conformationalchanges of lysozyme adsorbed on silica nanoparticles.Biochim Biophys Acta 1784, 1694–1701.29 Karlsson M, Martensson ... regulation of protein–protein interactions,cellular signal transduction and transcription of DNA[4–7]. Conformational transition, leading to peptideaggregation and the formation of amyloid ... addition of KCl and reached a maximum at 0.5 m KCl, beyondwhich further addition of KCl did not seem to haveany effect (Fig. 7). NPs have a strong destabilization effect on the structure of ToxRp....