... the antioxidant iron che-lator deferoxamine of PKA, localized in the mitochon-drial matrix [21], promoted CREB binding to the mtDNA D-loop. The presence in mitochondria of the CREB factor and, ... in the expression of mitochondriallyencoded proteins of the respiratory chain prompted us to investigate the mitochondrial import of the CREBprotein, synthesized in vitro, and its effect on the expression ... specificinhibitor of PKA. The addition to the mitochondrial protein synthesismixture of the RRL-synthesized NDUFS4 nuclear sub-unit of complex I, used as a control, had no effect on the synthesis of mitochondrially...