... within the molecule (Furlong, Immunosuppression – Role in Health and Diseases 42Mahrenholz et al. 1997) – one located in interdomain A, five within interdomain B, two within the kinase ... In the resting state, it is thought that Syk assumes a closed, auto-inhibited structure (Figure 1b), wherein interdomain A and interdomain B bind to the C-terminal kinase domain, preventing ... Immunosuppression – Role in Health and Diseases Edited by Suman Kapur and Maristela Barbosa Portela Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All...