... PR with the V32I mutation; PRI50V, PR with the I50V mutation; PRI54M, PR with the I54M mutation; PRI54V, PR with the I54V mutation; PRI84V, PR with the I84V mutation; PRL90M, PR with ... compared with PRWT–SQV. (B) PRI50V–APV compared with PRI50V–SQV. (C)PRI54M–APV compared with PRI54M–SQV. (D) PRI54V–APV compared with PRI54V–SQV. (E) PRI84V–APV compared with PRI84V–SQV. ... the complexes with both inhibitors.DiscussionWe have described an atomic resolution crystal struc-ture of PRWT with APV, and analyzed structuralchanges in the APV complexes with mutants PRV32I,PRI50V,PRI54M,PR154V,PRI84Vand...