Báo cáo khoa học: "TENSE TREES AS THE "FINE STRUCTURE" OF DISCOURSE" ppt

... might use Last T = {ei [ ei is the last-stored episode at the focus of T, or was stored in the subtree rooted at the focus of T after the last- stored episode at the focus of T}. Subsequent ... depending on the aspectual class of its first argument and on whether the focal node of T is past- dominated. In the Pert-rule, Last T is analogous to the Reichenbachian reference time for the perfect. ... Mary askedoe } whether I would want to go to Alaska some time. Note the shift to simple past in d, though as Web- bet points out, past perfect could have been used. The abandonment of the past...

Báo cáo khoa học: Methods to monitor the quaternary structure of G protein-coupled receptors doc

... in 50% of the maximalefficacy (R0). As indicated by the Fo¨rster equation, the efficiency of transfer varies inversely with the 6th-power of the distance. The extreme steepness of the relationship ... transfer, the efficiency of transfer is deter-mined both by the orientation of the energy transferpartners and by the distance between them [28]. The fact that the efficiency of transfer varies with the 6th-power ... trivial issues as the contribution of the back-ground signals can vary considerably depending on the relative expression levels of the FRET partners and the band pass width of the fluorescence...

Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx

... distributed in the nucleolus, nucleus and cytoplasm of the cell, as well as at the cell surface [10]. Nucleolin ⁄ C23 regulatesmany aspects of DNA and RNA metabolism, such as RNA polymerase I-mediated ... overexpressioninhibited H2O2-mediated release of Smac (the secondmitochondria-derived activator of caspases), activa-tion of caspase-3 and caspase-9, and apoptosis inC2C12 myogenic cells ... among the regulation of nucleo-lin ⁄ C23, the activation of caspase-3 and the induction of apoptosis under the setting of oxidative stress andHsp70 overexpression. More importantly, for the ﬁrsttime,...

Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf

... results, the inhibition by RTnI96)181was the strongest (94% of the ATPase was inhibited), suggesting that residues1–95 may decrease the inhibitory effects of residues96–181.On the other hand, ... of TnCs to the fragments in the presence (d) or absence (s )ofCa2+. The measurements were performed at 15 °C. The results were expressed as a percentage of the ATPase activity obtained in the ... TnI-fragments. The actomyosin-tropo-myosin Mg-ATPase was measured at increasing ratios of TnIor TnI-fragments to tropomyosin as indicated on the abscissa. The measurements were performed at 15 °C. The...

Tài liệu Báo cáo khoa học: "Event Matching Using the Transitive Closure of Dependency Relations" pdf

... derive dependency trees from head-lexicalized syntactic parse trees. The set of nonterminal labels associated with each word is the set of labels of the nodes for which that word was the head. For ... returns true if the morph of the descendant of deis the same as the morph of the descendant of ds, or if both descendants havecanonical mentions with an exact string match; the 3We remove ... President of Syria” and the sentence The resignation of Khaddam was abrupt” as an example. In particular, the “depth” features at-tempt to capture the “importance” the dependencymatch, as measured...

Tài liệu Báo cáo khoa học: Dimer asymmetry and the catalytic cycle of alkaline phosphatase from Escherichia coli doc

... to the magnesium binding site M3 [4].Fig. 4. The inﬂuence of Mg2+on the kinetic properties of APase fromE. coli. The inﬂuence of Mg2+on the kinetic properties of APase fromE. coli inthepresenceofaZn2+to ... shapes of the curves indicate that the mode of Mg2+activation is not the same for Zn2+2APase as for Zn2+4APase. The more pronounced activity increasewith Zn2+4APase is probably due to the ... to the Ser102 conformation and the nature of the metal ion boundto the M3 site [10]. The APasePistructure displays anincreased mobility of the active site with pronouncedanisotropy for the...

Báo cáo khoa học: Lipopolyamine treatment increases the efﬁcacy of intoxication with saporin and an anticancer saporin conjugate doc

... dimethylsulfoxide-facilitatedentry of saporin into the cytosol. The LEX2 inhibition of cargo delivery to the late endosomes would therebyincrease the pool of saporin available for passage from the early endosomes ... increase the pool of saporin available for passage from the endo-somes to the cytosol and would thereby generate anelevated state of toxin sensitivity in the LEX mutants.Escape from the endomembrane ... does not require the mechanism of ER-associated degradationExpression of an anticancer saporin chimera in the ER of Xenopus oocytes produced a drastic inhibition of translation in the RNA-injected...

Báo cáo khoa học: Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding pdf

... binding to the substrate via twoelements in ClpA, one in the N-domain and the otherin the pore of the ClpA hexamer. In the case of shortunstructured peptides or unfolded proteins such as casein, ... and the N-domain of RR ⁄ AA, and this result suggests that neither the local nor the overall structure of the RR ⁄ AA mutantwas compromised.Mutation of the conserved arginine residues hasonly ... together, these data suggest that ClpA utilizes two structural ele-ments, one in the N-domain and the other in the pore of the hexamer, both of which are required for efﬁcient unfolding of some...

Báo cáo khoa học: "Some Problems in the Mechanical Translation of German" pdf

... taken to be the subject of the clause. This ap- plies to about half of all the instances where the function of the relative pronoun is ambiguous. 2. On the other hand, if the form of the sub- ... shall write the equations in the form which they assume when these units are used.) If, on the other hand, the number of the relative pronoun proves to be identical with that of the following ... be made by the position of the verb because of the rule that in a subordinate clause the verb must normally come at the end. How, then, are we to deter- mine the function of the relative...

Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx

... which the N-terminus of the OTR is replaced with the corresponding sequence of the V1aR [10]. The role of the N-terminus has beenaddressed recently by alanine-scanning mutagenesis of the N-terminus ... the three classes of antagonist, the binding of AVP was dramatically affectedby the substitution of Arg46, with the afﬁnity of AVP for all the 19 mutant receptor constructs decreasing between ... stimulation of accumulated InsPs by increasingconcentrations of AVP, was assayed for each of the 19mutant constructs and the dose–response characteristicscompared to the wildtype V1aR. None of the...

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