Báo cáo khoa học: Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease doc

... Novel brain 14-3-3 interacting proteins involved in neurodegenerative disease Shaun Mackie* and Alastair AitkenUniversity of Edinburgh, School of Biomedical and Clinical Laboratory ... serine 1094 in the equiv-alent site in the mouse homologue (in a consensus binding motif for 14-3-3) abolished 14-3-3 binding to d-catenin in vitro and in transfected cells.d-catenin binds ... polyGln expansion. 14-3-3 and a-synuc-lein colocalize with the perinuclear inclusions ofhuntingtin protein [15].To identify novel 14-3-3 binding partners in mamma-lian brain, we performed a...

Báo cáo khoa học: Novel globoside-like oligosaccharide expression patterns in nontypeable Haemophilus inﬂuenzae lipopolysaccharide pdf

... strains 1200 and 1268 are representa-tive of this LPS structural motif in H. in uenzae. Oneglycoform containing full extension from both HepIIand HepIII was identiﬁed in minor amounts in strain ... within the human respiratorytract, at least in part by mediating bacterial adherenceto and invasion of the host epithelia [34–36]. A major-ity of H. in uenzae strains, including NTHi strains ... sialyltransferase involved in the biosynthesis ofsialyllactose in NTHi strain 1268.The main difference between strains 1268 and 1200was observed at HepIII where strain 1268 can besubstituted by a glycine...

Tài liệu Báo cáo khoa học: "Detecting Semantic Equivalence and Information Disparity in Cross-lingual Documents" doc

... portions in P1 that are more informa-tive than portions in P2 (forward entailment). In such cases, the entailing (more informative) portionsfrom P1 have to be translated and migrated to P2 in order ... complement them;(4) Text portions in P1 describing facts that are notpresent in P2, and vice-versa (the “unknown” cases in RTE parlance). In such cases, the novel infor-mation from both sides has ... occur in the original bilingual parallel cor-pora used for phrase table extraction. Our hypothe-sis is that the increase in recall obtained from relaxedmatches through semantic tags in place...

Tài liệu Báo cáo khoa học: Antioxidant protein 2 prevents methemoglobin formation in erythrocyte hemolysates doc

... determined that AOP2 was absentfrom porcine, murine, and human plasma (data not shown).To gain insight into how AOP2 interacts with itself orother proteins, RBC stroma proteins were examined usingnative ... hemoglobin in RBC lysate.Cysteine 47 is essential for AOP2-heme bindingThe binding of AOP2 and heme led us to investigate themechanism by which AOP2 binds to heme. All peroxire-doxin proteins ... beads cross linked to hemin, globin, or hemoglobin. AOP2bound to the heme molecule but not to globin or hemoglobin.Fig. 5. Cysteine is essential for AOP2 heme binding. Hemin, cross-linked to agarose...

Báo cáo khoa học: Characterization of natural vasostatin-containing peptides in rat heart docx

... MS)allowed us to investigate the N-terminal processing ofCGA in rat heart extracts. Our data reveal the pres-ence of several vasostatin I-containing and vasosta-tin II-containing peptides in the CGA(1–199) ... processes vasostatin-containingpeptides. This strongly suggests that these fragmentsplay a role in the autocrine ⁄ paracrine regulation ofcardiac function, being directly involved in the ino-tropic ... Analysis of thepost-translational processing of chromogranin A in ratneuroendocrine tissue employing an N-terminal site-speciﬁc antiserum. J Neuroendocrinol 13, 588–595.35 Lugardon K, Chasserot-Golaz...

Báo cáo khoa học: "Bypassed Alignment Graph for Learning Coordination in Japanese Sentences" doc

... between words in conjuncts.1 IntroductionCoordination remains one of the challenging prob-lems in natural language processing. One keycharacteristic of coordination explored in the pastis ... listedabove are concerned mainly with scope disam-biguation, reflecting the fact that detecting thepresence of coordinations in a sentence (Task 1)is straightforward in English. Indeed, nearly 100%precision ... only in the first word. Bothcontain a particle to, which is one of the most fre-quent coordination markers in Japanese—but onlythe first sentence contains a coordinate structure.Pattern matching...

Báo cáo khoa học: "A Study on Automatically Extracted Keywords in Text Categorization" doc

... number of keyword extracted per docu-ment in the training set is 6.4 and in the test set 6.1(not counting the empty documents).KeywordsTraining docs Test docs0 54 14168 362829 27232 ... tothe baseline. The best performance was obtainedwhen using a boolean feature value, and setting theminimum number of occurrence in training data tothree (giving an F-measure of 56.9%). In the ... 000newswire articles in English with multiple cate-gories (Lewis, 1997). More speciﬁcally, we usedthe ModApte split, containing 9 603 documents fortraining and 3 299 documents in the ﬁxed test...

Báo cáo khoa học: Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues docx

... protein kinase; MMP, matrix metalloproteinase; NF-jB, nuclear factor kappa B; PI3K,phosphatidylinositol 3-kinase; PKC, protein kinase C; Pyk2, proline-rich tyrosine kinase 2; RTK, receptor tyrosine ... (1993) High afﬁnity bindingand direct antiproliferative effects of luteinizing hor-mone-releasing hormone analogs in human endome-trial cancer cell lines. J Clin Endocrinol Metab 77,1458–1464.31 ... second messen-gers [protein kinase C (PKC) and cAMP] [26];(b) receptor -interacting proteins such as Src andb-zarrestin [53,75]; and (c) upstream kinases such asMAPK ⁄ ERK kinase and PI3K [53,76]....

Báo cáo khoa học: "The Descent of Hierarchy, and Selection in Relational Semantics" docx

... happening in (lo-cation) or done by the kidney. Immunoglobulin stain-ing, (D12 -Amino Acids, Peptides-, and Proteins, E05 -Investigative Techniques-) can mean either staining withimmunoglobulin ... from training instances, achieving about60% accuracy on an 18-way classiﬁcation problem us-ing a very small training set. That approach is bottomup and requires good coverage in the training set; ... Hor-mones and Amino Acids, while immunization falls underEnvironment and Public Health and Investigative Tech-niques. The meanings are immunization against inhibinor immunization using inhibin, and...

Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx

... 915Protein kinase Ch activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transductionpathway leading to apoptosis in L-MAT, a humanlymphoblastic T-cell lineSohel ... expressed in L-MAT, a human lymphoblastic T-cell line. In this report, we providethe following evidence that the protein kinase C (PKC)h activity is func-tionally involved in the AhR-independent ... of PKCh in theTCDD-induced AhR-independent signal transductionmechanism involved in L-MAT cell apoptosis.ResultsInhibition of TCDD-induced L-MAT cell apoptosisby rottlerin, an nPKC inhibitor12-O-Tetradecanoyl...

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