Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt
Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt
... role in the DNA damage response. In addition, the extreme COOH-terminalregion (amino acids 734–754) of Nbs1 mediates the interaction of Nbs1 with ATM and the recruitment of ATM to sites of DNA ... formation of MRNfoci [19–21]. The Mre11-binding domain of human Nbs1 hasbeen localized to amino acids 682–693 in the COOH-terminal region of the protein. Deletion of this region of Nbs1 results in ... damage, thereby promotingATM-dependent signaling [23]. Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins...
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Báo cáo khoa học: Dual role of oxygen during lipoxygenase reactions potx
... evaluations The quality of fitting of the kinetic model to the varioussets of experimental data was determined by the coefficient of determination B being the ratio of the explained variation of the data ... Kinetic modellingFor the derivation of the rate equations it was assumed thatfor the concentrations of the reactants used in the experi-ments, binding of the fatty acid substrate to the ... The other 15% of the total variation in y remains unexplained.Fitting procedureFitting of the kinetic model to the experimental data wasperformed by using a Visual Basic program that combinessolution...
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Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt
... effect of tyrosine phosphorylations on the binding affinity of ephrinB2(301–333) to the SH2 domain of Grb4 and to the PDZdomain of PDZ-RGS3. In the combination experiments, the two Cterminal tyrosine ... thenassess whether the binding of the PDZ domain of PDZ-RGS3 affects binding of the Grb4 SH2 domain tophosphorylated peptides, through studies of ternary inter-actions among the PDZ domain, ... unknown whether the two classes of effectors can bind to B ephrins simulta-neously or if the binding of one affects the binding of the other. We report here that phosphorylation of Tyr304 in the functional...
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Báo cáo khoa học: Lysosomal localization of GLUT8 in the testis – the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction docx
... GLUT8NICD to the tailless lumenal domain of the IL-2 receptor alpha chain (TAC)protein (interleukin-2 receptor a chain) targeted the protein to intracellularmembranes, indicating that its N-terminal ... lysosomalmarker protein LAMP1, a finding that is in agreementwith our in vitro binding data.Targeting of GLUT8 in the absence of AP1and AP2 In order to investigate the contribution of AP adap-tors, ... [19,20].However, the findings have been contradictory withregard to localization of the endogenous GLUT8 in tes-tis, the nature of its sorting, and the interaction of its N-terminal dileucine motif with the...
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... obese mice In order to gain insights into the potential biologicallyrelevant role of miR-27 in the regulation of adipose tis-sue functions in vivo, we examined the expression of miR-27 in the genetically ... together, these results illustratea critical and specific role of miR-27 in the regulation of adipogenic differentiation.miR-27 prevents the induction of PPARc andC⁄EBPa In order to delineate ... differentially regulatedor play a role under obese conditions in vivo. In the current study, we investigated the role of miRNAs in adipogenic differentiation using the mouseembryonic fibroblast-derived...
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Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... operates in the presence of thrombin (e.g. the PKA inhibitor H89reinforces the thrombin-induced Ca2+ response whenP2Y12is active). In addition, the present study demonstrates animportant role ... significantly extend the earlierwork investigating the interaction of P2Y12with P2Y1signaling [25,40]. We find that P2Y12enhances the thrombin-induced Ca2+ response in a way not onlyinvolving adenylyl ... Ca2+peak)resulted in an almost immediate abolition of the remaining part of the Ca2+signal, which then reached the level as in platelets preincubated with AR-C. In the experiments, a concentration of 2–5...
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Tài liệu Báo cáo khoa học: Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity docx
... obtained by other groupswho also point to the role of the connecting loop of the b-hairpin of defensins. A combination of mutationalanalysis [35] and structural analysis of the plant defensinRs-AFP1 ... moleculecomprising Ôresidues in the protruding domain consisting of the type VI b-turn and the first part of b-strand 3Õ (i.e. the b-hairpin loop and part of the adjoining b-sheet) andÔresidues in the loop ... is not possible to infer whether the key role of the b-hairpin loop of MGD1 (loop 3) in antimicrobial activity of MGD1 is of general value in the mechanism of action of defensins. However, our...
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... thisprotease at pH9 [10]. Further interest in the aromaticstacking is in the role of the electrostatic properties in enzymatic catalysis of API, and in distinguishing the functionally catalytic quadruple ... position. In the struc-tural deviation, the solvent ASA of the side-chain of His210increased with the decrease in size of the side-chain atresidue 169 (Table 1 and Fig. 3A). However, the ASAs of Asp113 ... size of the side-chain at residue 169 and the pK2showed a clear linear relationship (Fig. 3B). The pK2increased as the size of the residue at position 169 increased. The effect of the size of...
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Báo cáo khoa học: Biological role of bacterial inclusion bodies: a model for amyloid aggregation potx
... in the target recombinant protein[22]. The distribution of side chains in the sequence,such as occurs in protein folding, plays a pivotal role in determining the conformational properties of ... oxidativestress, the unfolded protein response, the heat shockand the stringent response and the activation of the DNA repair SOS system [2].Traditionally, lack of solubility and the formation of inclusion ... genetic instability (including plas-mid loss). These events occur in the context of severalcell stress responses, which depending on the nature of the host microorganism include triggering of oxidativestress,...
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Báo cáo khoa học: Dual modulation of prothrombin activation by the cyclopentapeptide plactin pptx
... identifiedprothrombin as one of the plasma cofactors. In incubations of U937 cellswith prothrombin and Xa, plactin increased the formation of thrombin,which cleaved single-chain u-PA to afford the inactive ... activateprothrombin, plactin D increased the level of a-throm-bin (Fig. 5B). Thus, the plactin D effects were increas-ing or decreasing the formation of a-thrombin without the accompanying conversion of ... bell-shapeddose response curves (Fig. 4). These properties of the plactin–prothrombin interaction suggested a change in the conformation of prothrombin after plactin bind-ing. We measured the intrinsic...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt nam