... characterization of HpSDH demonstrates its activity with kcat of 7.7 s)1and Km of 0.148 mmtoward shikimate, kcat of 7.1 s)1and Km of 0.182 mm toward NADP, kcat of 5.2 s)1and Km of ... Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China2 School of Pharmacy, East China University of Science and Technology, ... biosynthesis of p-aminoben-zoic acid and inhibit the growth of Escherichia coli[14,15]. In addition, a number of enzyme inhibitorshave been prepared to investigate the mechanism of the enzymes...