Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... respect to the role of HSP70 in the inhi-bition of the release of Smac and apoptosis. The role of the ATP-binding domain of HSP70 in the prevention of the release of Smac and apoptosis after exposure ... activation of caspases-9 and -3 and apoptosis. (A) The effects of HSP70 and its deletion mutant proteins on the acti-vation of caspases-9 and -3 were analyzed. Cells over-expressingHSP70 and its ... 2009 The Authors Journal compilation ª 2009 FEBS The ATP-binding domain of HSP70 is important for the interaction of HSP70 with apoptosis signal-regulating kinase 1 (ASK1) and the inhibition of ASK1-induced...
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Báo cáo khoa học: Mammalian 105 kDa heat shock family proteins suppress hydrogen peroxide-induced apoptosis through a p38 MAPK-dependent mitochondrial pathway in HeLa cells potx
... apoptosis upstream of rather than by direct inhibition of caspase- 3activation, as they do not suppress the activation of caspase- 3 mediated by heat shock. In mammalian cells, one of the main pathways ... staurosporine-induced apoptosis byinhibiting the translocation of Bax to mitochondria[19]. In contrast, Hsp105a has the opposite effects on apoptosis induced by H2O2 in mouse embryonal F9 cells, ... vital proteins [21–23]. In particular, caspase- 3 is one of the key executioners of apoptosis, as it is either par-tially or totally responsible for the proteolytic cleavage of many key proteins...
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Tài liệu Báo cáo khoa học: Nucleolin/C23 mediates the antiapoptotic effect of heat shock protein 70 during oxidative stress pptx
... apoptosis- inducing factor. Nat Cell Biol 3, 839–843.24 Jiang B, Wang K, Xiao W, Wang H & Xiao X (2009) ATP-binding domain of heat shock protein 70 is essen-tial for its effects on the inhibition ... November2009)doi:10.1111/j.1742-4658.2009.07510.xAlthough heat shock protein 70 (Hsp70) has been shown to markedly inhi-bit H2O2-induced apoptosis in C2C12 cells, and nucleolin ⁄ C23 has alsobeen implicated in apoptosis, the relationship of these ... the protection of Hsp70 is lost.Taken together, our results demonstrate an impor-tant relationship among the regulation of nucleo-lin ⁄ C23, the activation of caspase- 3 and the inductionof...
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Tài liệu Báo cáo khoa học: "Cross-Domain Co-Extraction of Sentiment and Topic Lexicons" pdf
... scheme for domain- transferproblem in the context of sentiment analysis. In Pro-ceedings of the 16th ACM conference on Conference on information and knowledge management, pages979–982, Lisbon, ... summarized in Algorithm 1, for expanding lexicons across do-mains. In each iteration, we employ a cross -domain classifier trained on the source domain lexicons and the extracted target domain lexicons ... Titov and Ryan McDonald. 2008. A joint model of text and aspect ratings for sentiment summarization. In Proceedings of the 46th Annual Meeting of the As-sociation of Computational Linguistics:...
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Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc
... assay, the enzymereaction product identified by GC-MS analysis, and the determination of released ammonia. The coupled enzymeassay revealed the mechanism of the deamination reaction and the subsequent ... ncolor. The enzyme s olution showed one main absorptionpeak at 266 nm and a broad absorption band in the visibleregion (Fig. 4). The excitation spectrum of the heat- treatedenzyme with emission ... anexcitation and emission wavelength of 450 and 530 nm,respectively. Ammonia release was determined by measur-ing the decrease in A340concomitant with NADPHoxidation in the presence of glutamate...
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Tài liệu Báo cáo khoa học: "Using Multiple Sources to Construct a Sentiment Sensitive Thesaurus for Cross-Domain Sentiment Classification" doc
... 2007) focuses on the challenge of training a classifier from one or more domains(source domains) and applying the trained classi-fier in a different domain (target domain) . A cross- domain sentiment ... shows the effect of combining multiplesource domains to build a sentiment classifier for the electronics domain. We see that the kitchen do-main is the single best source domain when adapt-ing ... improving the performance of our method in this domain. The analysis of vari-ance (ANOVA) and Tukey’s honestly significant dif-ferences (HSD) tests on the classification accuracies for the four domains...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... been demonstrated that the unfavourableinteraction between the peptide backbone and the osmolytes leading to the preferential hydration of the protein domain is the driving force of protein stabiliza-tion ... (a) the main driving force for the folding is the unfavourableinteraction between the osmolyte and the peptide back-bone, and (b) the total contribution of side chains to the stability of the ... of osmolytes on protein stability, folding and the activity of proteins and enzymes, the relationshipbetween protein stabilization by osmolytes and its con-sequent effects on the activity of...
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Báo cáo khoa học: A novel metallobridged bis(b-cyclodextrin)s fluorescent probe for the determination of glutathione doc
... experiments. In uence of the concentration of metallobridgedbis(b-CD)s 2 The in uence of the concentration of 2 on fluorescenceintensity is shown in Fig. 4. As can be seen, as the concentration of 2 increased, ... reaction was left to proceed for 10 min, and the fluorescence was then measured at room tem-perature. In uence of interference The in uence of the main constituents of plasma on the determination of ... dis-solved in aqueous solution and showed high bindingability because of the two adjacent bis(b-CD)s.Because of the conformation of the linker of 1, the nitrogen atoms and amido bond formed two...
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Báo cáo khoa học: Copper-containing nitrite reductase fromPseudomonas chlororaphis DSM 50135 Evidence for modulation of the rate of intramolecular electron transfer through nitrite binding to the type 2 copper center pot
... atom is then broken, yielding the product NO, whose release re-establishes the originalcoordination of the active center. HisB255 could be involved in the formation of additional hydrogen bonding, ... while the T2Cu is the catalytic center [7]. The study of this protein therefore entails the investigation of three redox processes: the reduction of T1Cu by anexternal electron donor, the intramolecular ... straight lines, confirming the applicability of the Nicholson and Shain theory to the present system, and the variation of the pseudo-first order rate constant with CuNirconcentrations (between 1 and...
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Báo cáo khoa học: "Cross-Domain Dependency Parsing Using a Deep Linguistic Grammar" docx
... shorter in BROWNthan that in WSJ. The common interpretation is that the test set is heterogeneous to the training set,hence in a different domain (in a loose sense). The typical cause of this is ... is that the model overfits the training domain. The concerns over randomchoice of training corpus leading to linguisticallyinadequate parsing systems increase over time.While the statistical ... test set from the children language component of the TalkBank,containing dialogs between parents and children.This is the other datasets used in the domain adap-tation track of the CoNLL 2007...
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