Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt

Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt

Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt

... ª 2009 FEBS 6083 MINIREVIEW Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 Nadja Bitomsky and Thomas G. Hofmann German Cancer Research ... PML Fig. 1. Regulation of DNA damage- induced cell death by p53 and HIPK2. Genotoxic stress-induced DNA damage facilitates activation of the D...
Ngày tải lên : 16/03/2014, 00:20
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Báo cáo khoa học: The SWI⁄SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt doc

Báo cáo khoa học: The SWI⁄SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt doc

... activa- tion of the G protein p21 Rho by deamidation of glutamine. Nature 387, 72 9–7 33. 24 Lanning CC, Ruiz-Velasco R & Williams CL (2003) Novel mechanism of the co -regulation of nuclear transport of SmgGDS ... ubiquitina- tion is of the degradative type and could regulate the level of BAF60b in SWI ⁄ SNF complexes. Our observations support the new idea of a dire...
Ngày tải lên : 06/03/2014, 09:22
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Báo cáo khoa học: Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7 pot

Báo cáo khoa học: Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7 pot

... least in the absence of an activating adaptor, generation of active human caspase-2 requires separation of its large and small subunits. In the context of autoactivation, removal of the prodomain ... approach defines specificities of members of the caspase family and granzyme B. Functional rela- tionships established for key mediators of apoptosis. J Biol Chem 272, 1790 7...
Ngày tải lên : 23/03/2014, 13:20
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf

Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf

... 3 4 50 – –+ + +–+ – – – ++ + ++ + –+ Fig. 9. GRASP55 is important for MT1-MMP–furin complex formation and activation of pro-MT1-MMP. (A) Lysates of bbHT1080 cells trans- fected with pCDNA3.1 ... then lysed and the extract was A 60 50 40 IB: MT1-MMP MT1-MMP pCDNA3.1 Zeo+ kDa +– –+ +– –+ 60 50 40 IB: GRASP55 50 40 IB: β-actin 12 IgG anti MT1-MMP B 60 5...
Ngày tải lên : 18/02/2014, 04:20
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

... TRAIL-induced apoptosis by CCCP. Oncol Rep 18, 7 1–7 6. 37 Park SY, Billiar TR & Seol DW (2002) Hypoxia inhibi- tion of apoptosis induced by tumor necrosis factor- related apoptosis- inducing ligand (TRAIL). ... chon- drocyte apoptosis and may suppress the progression of arthritis. Materials and methods Induction of OA Beagle dogs (n = 20) with a mean ± SD age of...
Ngày tải lên : 18/02/2014, 14:20
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Tài liệu Báo cáo khoa học: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5¢-phosphate synthases of fungi and archaea docx

Tài liệu Báo cáo khoa học: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5¢-phosphate synthases of fungi and archaea docx

... plants and a variety of enzyme reactions including certain dehydration and isomerisation reactions [ 1–3 ]. In view of the vital role of these coenzymes, it appears likely that biosynthesis of the ... units of guanylate kinase and 2 units of pyruvate kinase in a total volume of 0.5 mL, and were incubated for 30 min at 37 °C in order to generate the reductase substrate...
Ngày tải lên : 18/02/2014, 18:20
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Tài liệu Báo cáo khoa học: Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2 pptx

Tài liệu Báo cáo khoa học: Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2 pptx

... [2,3]. The lig- and for the tandem GAF domains of PDE2, PDE5, PDE6, and PDE11 is cGMP and that for PDE10 is cAMP. Usually ligand-binding enhances catalytic activity [ 4–6 ]. Two ACs of the cyanobacterium ... structures of the tandem GAF domains of PDE2 and cyaB2 do not reveal how cNMP specificity is enco- ded, we generated chimeras between the tandem GAF domains of cyaB1 a...
Ngày tải lên : 19/02/2014, 02:20
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Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc

Tài liệu Báo cáo khoa học:Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy doc

... activation of the Ras–Raf–Mek–Erk pathway and cell differentiation ⁄ hypertrophy through activation of the PI3 kinase– AKT–mTOR pathway [9]. Accordingly, IGF-1 treatment (5 ngÆmL )1 ) of C2C12 myoblasts ... nmol of the substrate 4-methylumbelliferyl N-acetylneuraminic acid (Sigma-Aldrich), 100 lg of BSA and aliquots of cytoso- lic fractions (5 0–1 00 lg of proteins) in a fi...
Ngày tải lên : 19/02/2014, 06:20
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Tài liệu Báo cáo khoa học: "An ERP-based Brain-Computer Interface for text entry using Rapid Serial Visual Presentation and Language Modeling" ppt

Tài liệu Báo cáo khoa học: "An ERP-based Brain-Computer Interface for text entry using Rapid Serial Visual Presentation and Language Modeling" ppt

... be a randomly-ordered set of all the letters (and the space and backspace symbols). The letters are randomly ordered for each sequence be- cause the magnitude of the ERP, hence the quality of the ... manufac- tured by g.tec (Austria), has 24 bits of precision and has 16 channels. We use a Butterworth bandpass fil- ter of 0.5 to 60 Hz, a 60 Hz notch filter, a sampling rate of...
Ngày tải lên : 20/02/2014, 05:20
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Tài liệu Báo cáo khoa học: The sensor protein KdpD inserts into the Escherichia coli membrane independent of the Sec translocase and YidC doc

Tài liệu Báo cáo khoa học: The sensor protein KdpD inserts into the Escherichia coli membrane independent of the Sec translocase and YidC doc

... the Escherichia coli membrane independent of the Sec translocase and YidC Sandra J. Facey and Andreas Kuhn Institute of Microbiology and Molecular Biology, University of Hohenheim, Stuttgart, Germany KdpD ... OmpA (upper panel) and KdpD (lower panel) and analysed by SDS/PAGE and visualized by phosphorimaging. The positions of the molecular weight standards (SeeBlue TM...
Ngày tải lên : 20/02/2014, 11:20
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