Click Here: The State of Online Advertising - New insights into the beliefs of consumers and professional marketers ppt

... adsOutdoor/out -of- home advertising Social Media EndorsementsThere are no good adsConsumer/User-Generated Content Advertising Created By Professional Marketers Consumers Marketers Rise of User-Generated ... each of the following? Top 2 Box 4,5 Click Here Study | October 2012 © 2012 Adobe Systems Incorporated. All rights reserved. Click Here: The State of Online Advertising New insights into the ... business and paramount to driving sales 7 Professional advertising is the most effective form of advertising, 27% of marketers believe that user-generated content is the most popular form of online...

Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx

... Superposition of the active-siteresidues of the 20 conformers of the solu-tion structure of HtA. Catalytic groups E66 and H113 are shown in red, and side chains of other residues in their vicinity ... F126–K128). The b-strandsform an N-terminal hairpin (b1 and b2) and an anti-parallel b-sheet (b3–b7). The remaining residues of the HtA sequence form large loops connecting the second-ary ... orientation of the N-terminal b-hairpin and loops 2 and 5 in HtA and a-sarcin. The backbone trace isrepresented in blue for the b-hairpin, orangefor loop 5, and green for loop 2. Side chains of lysine...

Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot

... N-gly-cans. N-glycans released from the heavychain (A) and LC1 (B) of RVV-X were perme-thylated and profiled by MALDI-MS. The N-glycans of LC1 and LC2 gave similar pro-files, and only that of ... uniquelinking to RVV-X HC, the light chains appear to con-fer the substrate specificities of RVV-X [12]. Collec-tively, the primary sequences of the three subunits of RVV-X (Figs 4 and 5) suggest the possible ... slower and smaller increment of FDP in vivo after the injection of desialylated RVV-X rather than intactRVV-X. As both RVV-X and RVV-V [34] are procoag-ulating glycoproteins in the same venom, the...

Báo cáo khoa học: New insights into the P-glycoprotein-mediated efﬂuxes of rhodamines doc

... (99mTc-MIBI) was performedwith a one-step kit formulation as described previously [9]. 2-[ 4-( Diphenylmethyl )-1 -piperazinyl]ethyl- 5-( trans-4, 6- dimethyl-1,3,2-dioxaphosphorinan-2-yl )-2 ,6-dimethyl- 4- (3-nitrophenyl )-3 -pyridinecarboxylate ... hydro-lysed are similar to each other and to the efficiency of the P-gp-mediated efflux of anthracyclines. This work repre-sents the first report, using intact cells, of real-timemeasurements of the ... diffusionthrough the plasma membrane and then the kineticparameters characteristic of their P-gp-mediated efflux.Our data show that the efficiencies of the P-gp-mediatedefflux of Rh I, Rh II,...

Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

... pantothe-nate from low amounts of pantoate [9]. Here, wereport the results of the structural studies of the panto-ate-bound form of the N-terminal domain of E. coliPS (nPS). The structure and ... inhibition by another sub-strate of the enzyme, ATP, are presented [8,9].ResultsSolution properties of the N-terminal domain of PS, the C-terminal domain of PS, and full-lengthPSFull-length PS ... observed in the case of ade-nylosuccinate synthetase, one of whose substrates,IMP, binds to the GTP-binding site and inhibits the reaction [37–39]. The binding of pantoate to the ATP-binding site...

Tài liệu Báo cáo Y học: Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization ﬁeld pptx

... to the WSM, and consequently the EDTA-IM. Hydroxyproline, hydroxy-lysine and phosphoserine were not detected in WSM, WIM,EDTA-SM and EDTA-IM. The comparison of the amino acid composition of the main ... separate the EDTA-soluble matrix(EDTA-SM) from the EDTA-insoluble matrix (EDTA-IM).ToremoveEDTA,thetwosampleswereextensivelydialyzed against ultra-pure water (Milli-QTM), at 4 °C, and the EDTA-SM ... modes of the organic matrix compo-nents) and another, the most intense, at 1593 cm)1, possiblycorresponding to the COO coordinated asymmetric stretch-ing band. The presence of this band resulted...

Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot

... scanning cal-orimetry, of bovine b-andj-casein, recombinant human a-,b-andc-synuclein, together with the A30P and A53T mu-tants of a-synuclein associated with familial cases of Par-kinson's ... longer-chain (and nonglobular) versions of the structure of the Bowman±Birk inhibitor in Fig. 6 . The X-ray crystal structure 1 pi2 reveals that the /,w angles of most of the residues of the Bowman±Birk ... DISCUSSIONROA measurements on b- and j-casein The caseins constitute nearly 80% of bovine milk pro-teins. The major components, aS1 -, aS2 -, b-andj-casein,occur in milk in the proportions (mass fractions)0.37...

Báo cáo khoa học: Complexes of Thermoactinomyces vulgaris R-47 a-amylase 1 and pullulan model oligossacharides provide new insight into the mechanism for recognizing substrates with a-(1,6) glycosidic linkages docx

... E396Q) and a pullulan model oligosaccharide (P2; [Glc-a-(1,6 )- Glc-a-(1,4)-Glc-a-(1,4)]2or P5; [Glc-a-(1,6)-Glc-a-(1,4)-Glc-a-(1,4)]5) weredetermined. The complex D356N ⁄ P2 is a mimic of the ... D356N; Asp356 to Asn and Glu396to Gln, D356N ⁄ E396Q) and pullulan model oligosac-charides (P2; [Glc-a (1,6)-Glc-a-(1,4)-Glc-a-(1,4)]2 and P5; [Glc-a-(1,6)-Glc-a-(1,4)-Glc-a-(1,4)]5); D356N ... pullulan at the same sites as TVAI [10].Although the crystal structure of BNPL in com-plexes with panose [Glc-a-(1,6)-Glc-a-(1,4)-Glc], iso-panose [Glc-a-(1,4)-Glc-a-(1,6)-Glc], and maltotetraose[Glc-a-(1,4)-Glc-a-(1,4)-Glc-a-(1,4)-Glc]...

PERIPHERAL NEUROPATHY - A NEW INSIGHT INTO THE MECHANISM, EVALUATION AND MANAGEMENT OF A COMPLEX DISORDER doc

... scientist, and then describehow the manifestations of these pathophysiologic changes are observed in the clinic, as seenby a clinician. It will then discuss a merger of the two points of view and ... I-IV) and integration (laminae V) of painful and non-painful stimuli at the level of the spinal cord, providing the substrate for distinct pathophy‐siological mechanisms in the development of ... originating from the orofacial region project to the trigeminal nucleus caudalis of the medulla rather than the dorsal horn of the spinal cord [37].Similar organization, function, and pathophysiological...

Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... conformationaround the active site of ApeSOD is independent of the presence of a metal cofactor.Figure 3D shows the superimposition of the activesite structures of apo, Mn-bound and Fe-bound Ape-SODs. The ... bedivided into two groups: one with almost the sameactivity in the Mn- and Fe-forms, and the other exhib-iting low activity in the Fe-form and high activity inMn-form. ApeSOD belongs to the latter ... inhibi-tion of the binding of the superoxide substrate and the other to product inhibition by hydrogen peroxide.There are two mechanisms proposed for the reactioncycle of Mn ⁄ Fe-SOD: the 5-6 -5 ...

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