Báo cáo khoa học: Enzymes of mannitol metabolism in the human pathogenic fungusAspergillus fumigatus– kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications pot
... metabolism in the human pathogenic
fungus Aspergillus fumigatus – kinetic properties of
mannitol- 1-phosphate 5-dehydrogenase and mannitol
2-dehydrogenase, and their physiological implications
Stefan ... M2DH
Interpretation of the kinetic properties of an enzyme in
the context of its role in cellular metabolism relies on
knowledge of the...
... role in the maintenance of cell survival, but is also
responsible for the up-regulation of glucose metabo-
lism and the induction of lipogenesis [37–40]. We
hypothesized that signaling via the ... HIF-1a
is involved directly in the accumulation of lipids trig-
gered by QDs under the conditions of uncompromised
cell survival in the presence of serum.
On the...
... kinetically in uential
ionizations were identified in plots of k
lim
⁄ K
d
of pK
a
values 7.1 and 9.3,
again with the maximum value realized in the alkaline region. The poten-
tial origin of these kinetically ... substrate carbinolamine intermediate;
III, iminoquinone intermediate; IV, product Schiff base intermediate;
V, aminoquinol intermediate. In the oxidative half-r...
... December
2010)
doi:10.1111/j.1742-4658.2010.07980.x
The escalating prevalence of obesity is one of the most pressing health
concerns of the modern era, yet existing medicines to combat this global
pandemic are disappointingly limited in terms ... cyclin ⁄ cyclin-dependent
kinase holoenzymes, releasing the E2F complex and
thereby resulting in activation of the E2F targe...
... SRE
fos
and SRE
Gfos
,
on the one hand, and SRE
GGfos
, on the other hand,
consists in the distinct strains acting on the helix ply of
these oligonucleotides. Conversion between the bent
and linear ... tem-
peratures. The increase in intensity of the 926 (924),
1444 and 1462 cm
)1
vibrational bands of deoxyribose
and of the 790 and 1056 cm
)1
bands of...
... already present
in the LSP grammar.
Figure 1 shows a sample definition and the
triples the parser found in it.
ABDOMEN 0 1 N THE PART OF THE BODY
BETWEEN THE THORAX AND THE
PELVIS
(THE) pmod ... the node to the right of the taxonomy marker
'W") serving as a pointer to its own defining node.
The resulting network is quite dense. We simplify b...
... described for the
sulfuration of the C-terminal glycine in ThiS and
MoaD, involved in thiamine biosynthesis and molyb-
dopterin biosynthesis, respectively, and for the sulfura-
tion of uridine in tRNA ... phenylalanine instead of a
tyrosine directly before the thioglycine (Methanoculleus
thermophilus and Methanosarcina barkeri) or directly
after the thioglycine (...
... Therefore,
the incoming Na
+
ion is thought to weaken the rather
strong interaction between the arginine and the bind-
ing site and to promote its loading onto the binding
site, aided by the membrane potential ... arriving from the periplasm
from escaping to the cytoplasm.
In order to gain insight into the interaction of the
stator arginine with the binding site,...
... contribute to the induction
of oxidative stress during ischemia ⁄ reperfusion in
brain.
There is a growing body of information concerning
the mechanism of ROS generation by the respiratory
chain in mitochondria. ... this
treatment. The high degree of protection by ADP sug-
gests that the mitochondrial injury is caused by open-
ing of the mPTP. There is evidence that...
... positioning of CA. Mutation
of all arginines led to a significant loss in protein stability
suggesting that they are involved in protein fold structure
rather than binding of the substrate.
The overall ... explain the complete impairment of
substrate binding and the increased stability of the mutant
protein. The orientation and size of SRS 6 is quite variable
be...