... from 8 to 1779. Table 2. Teaching Physical Signs and Symptoms of Chronic GVHD to Children and ParentsSites Signs and Symptoms to ObserveSkin Check for skin changes: skin color may deepen and ... cells can initiate a response against autoantigens leading to B-cell hyperre-activity and production of autoantibodies, causing target-organ damage, including skin, mucosa, eyes, joints, and liver ... is initiated, T-cells produce additional proinflammatory cytokines, including tumor necrosis fac-tor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-2, which in turn attract more T-cells to...