... the catalytic site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the other face each other, thereby bringing together the substrate-binding ... (Arg405, Lys407,Lys413, Lys414, Lys422, Lys428, and Lys430) oriented in the same direction with the heparin-binding domain at the N-terminal end [14]. The other is a cluster of tryptophans(Trp390, ... (40% similarity) and are28% identical in the C-terminal domain (38% similarity). The catalytic efficiency and heparin-binding functions of the N-terminal domain have been extensively studied[13,14]....