... coding for the subunits of CytOX, changes in the microenvironment of the cell may induce alterations in the catalytic efficiency of mammalian enzyme. Selective loss of CytOX subunits I/II and IV might ... [4,5]. The remaining 10 subunits of the mammalian enzyme, namely, IV, Vb, VIa, VIb, VIc, VIIa,VIIb and VIII are encoded by the nuclear genome,synthesized in the cytosol and imported into mitochondria[1–3]. ... enhance the catalytic efficiency of the enzyme [8,9], the precise role of many nuclear-encoded subunits in the mammalian enzyme complex remains unknown.Oxygen as a substrate and heme as a prosthetic...