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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703 pdf

Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703 pdf

... promotes the activation of caspases, such as procaspase-9 and caspase-3,by binding to the inhibitor of apoptosis proteins and thusdisrupts linkage of the caspase–inhibitor of apoptosisproteins ... required to remove the inhibitory effect of X-linked inhibitor of apoptosis protein (XIAP) and allowapoptosis to proceed, and thus mediates the contribution of the mitochondrial pathway to death ... affect the protein level of tBid.We also examined the expression of tBid and Bax bycombined treatment of TRAIL and etoposide; these resultsare shown in Fig. 4C. The protein levels of both tBid and Bax...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

... Biochem. 270) Ó FEBS 2003 Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase Katrina MacAulay1, Eric Hajduch1, ... phosphatidylinositol3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammaliantarget of rapamycin (mTOR) pathway in the L-leucine-inducedup -regulation ... hands.Effects of insulin, Li and SB-415286 on signallingelements implicated in the regulation of GSK3 and GS To further understand the effects of Li and SB-415286 oncell signalling events we assessed their...
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Tài liệu Báo cáo khoa học: Use of hydrostatic pressure to produce ‘native’ monomers of yeast enolase ppt

Tài liệu Báo cáo khoa học: Use of hydrostatic pressure to produce ‘native’ monomers of yeast enolase ppt

... mixture of b-sheet and a-helices. The dimer interface includes two helices in the large domain and two b-strands in the small domain. The active site is at the bottom of the barrel and is totallyCorrespondence ... nd function of the protein usually involvedissociating the protein into its subunits and then compar-ing the properties of the monomeric and oligomeric forms.Often, the r esulting monomers ... Samples used for equilibriu minactivation experiments contained 0.04 mgÆmL)1BSA. The albumin was a dded in order to minimize losses of activity due to absorption of enolase to the sides of the cuvette...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Use of Mutual Information Based Character Clusters in Dictionary-less Morphological Analysis of Japanese" ppt

... analysis involving the Japanese language, how knowing the sort of each character is use- ful when tokenizing a string of characters into a string of words and when assigning parts -of- speech to them, ... to obtain hierarchical clusters of words by classifying words in such a way so as to minimizes the reduction of MI. This idea is general in the clustering of any kind of list of items into ... neighbor to one of the other groups of char- acters, and supposing characters are clustered and organized in a hierarchical fashion, then it is possible to refer to such groupings by pointing ~Other...
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Báo cáo khoa học:

Báo cáo khoa học: "USE OF HERRISTIC KNOWLEDGE IN CHINNESE LANGUAGE ANALYSIS" ppt

... In another exa~ole, in English, "-ing" is used to indicate a participle, or "-ed" can be used to distinguish passive mode from active. In Chinese, there is nothing to indicate ... English, there are few formal inflections to indicate the grammatical category of a word, and the few inflections that do exist are often omitted. In English, postfixes are often used to distinguish ... call them "characteristic words". Several hundreds of these words have been collected by linguists[2] ,and they are often used to distinguish the detailed meaning in each part of...
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Báo cáo khoa học: Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice doc

Báo cáo khoa học: Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice doc

... of the kinetics of accumulation of soluble CD69 receptors in the liver and kidney indicates a fast uptake of the proteins witha short half-life in plasma into these organs, particularinto the ... both the long circulation and the intactness of the moststable human CD69 protein (together with its rat and mouse orthologs) in the blood of mice. For theseproteins, approximately 40% of the initial ... molarextinction coefficient of the protein, and thus the increase in absorbance in the aromatic region. Shortlythereafter, a gradual unfolding of the protein occursthat results in the increase of...
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Báo cáo khoa học: Use of biomolecular templates for the fabrication of metal nanowires ppt

Báo cáo khoa học: Use of biomolecular templates for the fabrication of metal nanowires ppt

... lithography’. In photolithography, a photoresist layer is deposited on the silicone oxidesurface. The use of a mask allows differential treatment of the photoresist and the etching of specific parts of the ... areformed. The application of these wires was recentlydemonstrated for the fabrication of electrodes for thin lithium- ion batteries [38]. The binding of gold to the viruses followed by reduction of the ... anotherdimension to the biological template of nanowires, asthese elements can be translated at the nano-scaleusing biological nanomotors. The myosin nanomotorcan bind actin fibers and use...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf

Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf

... AG1478-inducedapoptosis in PC-9 cells.Stress stimuli that induce apoptosis, includingUV- and c-irradiation, heat shock, protein synthesisinhibitors, DNA-damaging agents and the proinflam-matory ... for the release of mitochondrial proapoptoticmolecules (including cytochrome c) and apoptosis in response to UV radiation [48]. Bax and Bak (members of the proapoptotic group of multidomain Bcl-2-relatedproteins) ... differentiation and survival of various celltypes. Ligand binding to EGFR results in receptordimerization, activation of its tyrosine kinase and phosphorylation of its C-terminal tyrosine residues.The...
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Tài liệu Báo cáo khoa học: Evidence for noncooperative metal binding to the a domain of human metallothionein ppt

Tài liệu Báo cáo khoa học: Evidence for noncooperative metal binding to the a domain of human metallothionein ppt

... mechanisms of the individual domains, in the hope, initially, of simplifying the interpretation of the metallation details of the two-domain protein. The results presented here allow successful and ... Sequence of the a domain of rhMT-1a, showing the connectivities of the four divalent metal cations to the 11 cystei-nyl sulfurs. The numbering of the cysteines(1–11 starting from the N-terminus) and ... respect to the lability of the zinc ions and that, despite the increased thermodynamic stability of the a domain with Zn2+over the b domain, the Zn2+sites in the a domain were shown to be more...
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Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc

Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc

... example, in order to save energy and protein synthesizing capa-city. This would be preferable to placing all the genesinvolved in the pathway in the same operon; the cellcan then respond quickly to ... phosphoenolpyruvate to pyruvate,is encoded by the second gene in the las operon (Fig. 1). In order to obtain strains with increased PK activity anadditional copy of the pyk gene was recombined into the TP901-1 ... proportional to the change in PK activity. The data points for growth and glucose flux were then fitted against the PK activities in order to determine the control exerted by PK over the growth rate...
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