Báo cáo khoa học: Uptake and metabolism of [3H]anandamide by rabbit platelets Lack of transporter? ppt

... Uptake and metabolism of [3H]anandamide by rabbit platelets Lack of transporter? Lambrini Fasia, Vivi Karava and Athanassia Siafaka-KapadaiDepartment of Chemistry (Biochemistry), ... involvement of FAAH on[3H]anandamide uptake and metabolism by rabbit platelets, the effect of phenylmethylsulfonyl ﬂuoride on [3H]ananda-mide uptake was determined (Fig. 5). Preincubation of theplatelet ... between human and rabbit platelets, since[3H]anandamide is not taken up by a carrier-mediatedprocess in rabbit platelets in contrast to human platelets. Anandamide is taken up by rabbit platelets...

Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf

... equation of Fluo-3 forCa2+[27]. Ultra-pure calcium-free water was used forpreparation of all buffers and (ant)agonists.Measurement of cytosolic cAMP and InsP3Intracellular levels of cAMP and ... Ca2+response, and abolished the effects of ADP, AR-C and wortmanninABCDFig. 6. Contribution of SERCA and phospholipase C to P2Y12-dependent prolongation of Ca2+responses. (A, B) Fura-2-loaded platelets ... importance of the PI3-Kb isoform.PI3-Kb and not PI3-Kc mediates P2Y12-dependentprocoagulant activity of mouse and human platelets Prolonged elevation in [Ca2+]ican signal for surfaceexposure of...

Báo cáo khoa học: "Computing and Evaluating Syntactic Complexity Features for Automated Scoring of Spontaneous Non-Native Speech" pot

... model of language ability, and therefore is often used as an index of language proficiency and development status of L2 learners. Various studies have proposed and inves-tigated measures of ... relevant to be evaluated both by a human rater and an automated scoring system. Examples of such aspects of speech, which are considered part of the construct1 of “communicative competence ... diversity, and aspects of spoken discourse structure, e.g., coherence and cohesion. These different aspects of speaking pro-ficiency are often highly correlated in a non-native speaker (Xi and Mollaun,...

Tài liệu Báo cáo khoa học: "Instance-based Sentence Boundary Determination by Optimization for Natural Language Generation" ppt

... boundary determination by balanc-ing a comprehensive set of sentence com-plexity and quality related constraints.Second, our approach can simulate thecharacteristics and the style of naturallyoccurring ... syntactic and lex-ical realizability, and its smoothness between sen-tence transitions. Sentences that are too complex arehard to understand, so are sentences lacking seman-tic cohesion and cross-sentence ... generated speech and graphics, as the response (Zhou and Aggarwal,2004). The proposed sentence boundary determi-nation module takes a set of propositions selected by a content planner and passes...

Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx

... hydroxylgroups are present at positions 20 and 23. Three minor products of D3 metabolism by P450scc were identified by MS and by examining their sub-sequent metabolism by P450scc. These products were 23-hydroxyvitaminD3, ... the major and minor pathways forthe metabolism of vitamin D3 by P450scc.Results Metabolism of vitamin D3 by P450sccSix different products, in sufficient amounts to permitquantitation and subsequent ... identification of new metabolites of vitamin D3 made by the action of P450scc willenable us to proceed with further biological testing of these compounds and the investigation of whether thispathway...

Báo cáo khoa học: Discovery and characterization of a Coenzyme A disulﬁde reductase from Pyrococcus horikoshii Implications for the disulﬁde metabolism of anaerobic hyperthermophiles doc

... disulfides, and assayed as above. Thiols were quanti-fied by comparison of peak areas to standard curves of those standards. Coenzyme A was measured as the sum of the areas of the CoA and dephospho ... and thermoactivity of the CoADRphCoADR is stable for months at both )80 °C and )20 °C, and has half-lives of > 100 and 39 h at 85° and 95 °C, respectively. Figure 3 shows the dependence of ... yield of 58% and a specific activity of 3.26 UÆmg)1(oxidase activity)(Table 1) and 8.3 UÆmg)1(CoADR activity). ThephCoADR had a subunit m ¼ 50 k as determined by SDS ⁄ PAGE, and was shown by...

Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf

... withbinding of both MOF and Tip60 (equivalent to Esa1in yeast NuA4) [124,130]. However, in human cellsdepletion of MOF, but not Tip60, results in reducedglobal levels of AcH4-K16 and defective ... acetylation and deacetyla-tion, and transient recruitment of remodellers and transcription factors.A cycle of transcription commences with the recruit-ment of transcription factors and co-factors ... Composition of nucleosomes. The assembly of the histoneoctamer on DNA is represented by this model which depicts theincorporation of two H3 ⁄ H4 dimers with an inner core of  60 bp of DNA, followed by...

Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx

... expression of estrogen receptor-a(ERa) is autoregulated by miR-18a, -19b and -20b,which in turn are upregulated by the activation of ERa. This mechanism of regulation provides a widerange of coordinated ... Scientiﬁc Fund of the Ministry of Education,Science and Culture of Japan (G.T.); the Program forPromotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical InnovationTable ... by lipopolysaccharide viathe activation of the receptor TLR4 and also isinvolved in the feedback control of nuclear factorkappa B (NF-jB)-dependent responses by inhibitingthe expression of...

Tài liệu Báo cáo khoa học: Functional and structural analyses of N-acylsulfonamidelinked dinucleoside inhibitors of RNase A ppt

... Department of Biology and Biochemistry, University of Bath, UK2 Department of Biochemistry, University of Wisconsin–Madison, USA3 Department of Chemistry, University of Wisconsin–Madison, USAIntroductionUpon ... phosphoryl group.Results and DiscussionSulfonimides as inhibitors of RNase AWe began by determining the ability of three backboneanalogs of RNA to inhibit catalysis by RNase A.These analogs ... studies of the structure and binding sites of enzymes. 8. Inhibitor binding toribonucleases. J Mol Biol 45, 491–511.33 Ui N (1971) Isoelectric points and conformation of proteins. I. Effect of urea...

Tài liệu Báo cáo khoa học: Active and regulatory sites of cytosolic 5¢-nucleotidase doc

... Model of the homotetrameric quaternary structure of cN-IIshowing interfaces A and B and the Mg2+site. The inset showsthe tertiary structure of each subunit. Effector sites 1 and 2 and the ... alteration of this ratio for amutant was considered as caused either by an alteration of the Kmvalue for one of the two substrates or by a variation of the kcatvalue for one of the two activities. ... and the effect of theenzyme activators ATP and Mg2+is also unchanged(Table 1). Furthermore, by simultaneously measuringthe rate of nucleoside and phosphate production fromIMP and monophosphate...

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