Báo cáo khoa học: Functional ﬁne-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin protein pdf

Báo cáo khoa học: Enzymatic characterization and molecular modeling of an evolutionarily interesting fungal b-N-acetylhexosaminidase pot

... clear competition between pNP-GalNAc and GalNAcfor the active site of the enzyme. The amino acids of the loop that come into closeproximity to pNP-GlcNAc and GlcNAc at the ‘sec-ondary’ binding ... incorporates a consistency score to evaluate align-ment. A structural alignment of the three templates wasadditionally made with the sheba plug-in and visualizedwith the program yasara [36]. ... long loop moved by morethan 0.3 nm.Most (83.5%) of the amino acid residues are plottedin the favourable regions of the Ramachandran plot. The deviation of geometrical parameters from idealvalues...

Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the speciﬁcity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf

... substrates. The data for the PA catalysed hydrolysis of PhAc-Asp and PhAc-Glu[13] and our data for PhAc-pAB, PhAc-mAB and PhAc-oAB (Table 2) imply that the COOH group has to be posi-tioned as ... properties. The kinetic para-meters of the PA-catalysed hydrolysis of the studiedphenylacetyl arylamides are compared in Table 2. The substrates are arranged in a decreasing order of the ratio of their ... stabil-ization of the tetrahedral intermediate. Experimental data[21] for the efﬁcient hydrolysis of NIPAB catalysed by the ArgB263Lys mutant PA and the lack of hydrolytic activityfor the ArgB263Leu PA...

Báo cáo khoa học: Functional ﬁne-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin protein pdf

... 2003 Fine-mapping of an epitope of measles virus (Eur. J. Biochem. 270) 1527 Functional ﬁne-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin protein Mike ... [32].Evenasmallsidechaininposition388wouldresultinsterichindrance with the main-chain nitrogen atom of K389,damaging the shape of the loop. The above spatialarrangement explains that the HNE epitope does not form a continuous stretch of contact residues. ... beenpartially induced against the linear isoform of the HNEpeptide. Although the binding pattern may be somewhatblurred by these antibodies and by the polyclonal nature of the sera, the importance...

Tài liệu Báo cáo khoa học: Functional expression and mutational analysis of ﬂavonol synthase from Citrus unshiu pptx

... origin, catalyze reactions of medicinal and industrial relevance, and their spatial organization and mode of action are under investigation. The reactions arediverse, such as the desaturation of aliphatic ... thaliana, Persea americana,Ipomea purpurea, Ipomea nil and Medicago sativa), three anthocyanidin synthases (Zea mays, Anthirrhinum majus and Oryza sativa), five gibberellinC20 oxidases (Arabidopsis ... Eustoma grandiflorum, Malus domestica and Matthiola incana), but functionality was only verified incase of Petunia and Arabidopsis [15,16]. In the course of ourresearch on Rutaceae [41–43], we became...

Báo cáo khoa học: Functional characterization and Me2+ ion speciﬁcity of a Ca2+–citrate transporter from Enterococcus faecalis1 pdf

... of the family reveals that the three members associated with the fermentative citratepathways of S. mutans, S. pyogenes and E. faecalis areon a separate branch of the tree that is well separatedfrom ... The results suggestthat the complex of Ca2+ and citrate is the truesubstrate of EfCitH and that the low uptake in the absence of added Ca2+was due to contaminatingfree Ca2+in the assay ... contained the citrate lyase genes,most of them either from the c-subdivision of the Proteobacteria or the Bacillales and Clostridia of the Firmicutes. Despite the low spread, there was a remarkable...

Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf

... Yamazaki K, Maeda A, KurosakiT, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K,Imoto K & Mori Y (1999) Molecular and functional characterization of a novel mouse transient receptorpotential ... Paradoxicalinﬂuence of calcium ions on the permeability of the cellmembranes of the isolated rat heart. Nature 211, 646–647.196 Duncan CJ & Morton JW (1996) Membrane damage and the Ca2+-paradox in the ... pyruvate, alpha-ketoglutarate, and branched-chain alpha-keto acids in rat liver mitochon-dria: presence of interaction between the glycine clea-vage system and alpha-keto acid dehydrogenasecomplexes....

Báo cáo khoa học: "Capturing Paradigmatic and Syntagmatic Lexical Relations: Towards Accurate Chinese Part-of-Speech Tagging" pdf

... comparatively analyzesyntax-free and syntax-based models and employ a Bagging model to integrate a sequential tagger and a chart parser to capture syntagmatic relations thathave a great impact ... anal-ysis. Both paradigmatic and syntagmatic lexical re-lations have a great impact on POS tagging, because the value of a word is determined by the two rela-tions. Our error analysis of a ... Chinese, a PCFG-LA parser achieves the state -of- the- art performance and defeat manyother types of parsers (Zhang and Clark, 2009). Forfull parsing, the Berkeley parser6, an open sourceimplementation...

Báo cáo khoa học: "INCORPORATING INHERITANCE AND FEATURE STRUCTURES INTO A LOGIC GRAMMAR FORMALISM" pptx

... treated as a context-free grammar rule and the interpreter automatically appends two additional arguments (start and end) to facilitate parsing. The final syntactic sugar allows feature labels ... accommodated naturally. OTHER GRAMMATICAL APPLICATIONS OF TAXONOMIC REASONING The taxonomic reasoning mechanism of IG has applications in lexical and syntactic categorization as well as in semantic ... directed graph. Each node (both leaf and interior) is annotated with a symbol from the signature. Each arc of the graph is labelled with a feature label (an attribute). The set of feature labels...

Tài liệu Báo cáo khoa học: Hypoxia downregulates farnesoid X receptor via a hypoxia-inducible factor-independent but p38 mitogen-activated protein kinase-dependent pathway doc

... Saitou1, Takehisa Atsumi1, Takashi Sato1, Ken Ando1, Shuntaro Hara2, KiyomiKikugawa1 and Makio Hayakawa11 School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan2 ... sets of primers [set 1, 5¢-TAGTCCAGTGTGGTGGAATTCTGC-3¢ (sense) and 5¢-AAAGCATCAGGTTCCTTCTTAAG-3¢ (antisense); set 2, 5¢-AACTTTGCTGGCCGCCGCCGCTGG-3¢ (sense) and 5¢-GGCAACTAGAAGGCACAGTCGAGG-3¢ ... of a balancebetween bile acid uptake, efﬂux, and biosynthesis.Maintenance of this balance is essential, as most bileacids are cytotoxic. Cholestasis, a medical conditioncharacterized by the...

Báo cáo khoa học: "What’s There to Talk About? A Multi-Modal Model of Referring Behavior in the Presence of Shared Visual Information" potx

... on the right, and a view of the Worker’s work area in the left hand panel. The advantage of this setup is that it allows exploration of a number of different arrangements of the shared visual ... data analysis, as well as our qualitative examina-tion of the data, that the pairs make tradeoffs be-tween relying on the linguistic context and the visual context. Our current instantiation ... the basic ex-perimental paradigm and detail how it can be used to examine the impact of various features of a shared visual space on communication. 4 The Puzzle Task Corpus The corpus data...

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