Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx
Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx
... FEBS 2003 Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast Catherine Duport1,*, Barbara Schoepp1,†, Elise Chatelain1, Roberto ... The levels of expression of variousproteins (Adxp, Adrp, CYP11A1) involved in the reactioncan also affect the efficiency of cholesterol side chain cleavage. Indeed, it is apparent that the expression ... gene. Therefore, both free pregnenoloneproduction and the efficient coupling of the SCC and the 3b-HSD activities in yeast require the use of strains lackingthis acetylating activity. For this...
- 13
- 441
- 0
Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: a new view of palytoxin toxicity ppt
... accumulation of the toxin by the food chain in the organisms living close to the zoan-thid colonies [3].It has been reported that dinoflagellates of the genusOstreopsis are the most probable origin of ... impor-tance of the unpolymerized actin pool for the mainte-nance of the F-actin system, the cellular responseFig. 3. Response induced by palytoxin and ostreocin-D on the actin cytoskeleton of neuroblastoma ... analysis[28]. There were two reasons for starting this type of study with an intestinal model: (a) the great complexity of the actin cytoskeleton in these cells; and (b) the severe gastrointestinal toxicity...
- 8
- 691
- 0
Báo cáo khoa học: Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding pptx
... into the GCPII-binding pocket and proposed/analyzed the amino acid residues involved in the ligand–protein interactions. All of the residues identified aresituated within the segment spanning ... Arg538,i.e. the putative catalytic domain (domain E) and the Ddomain of rat GCPII. The contribution of domains C and Fto the GCPII hydrolytic activity/ inhibitor binding remainsto be established. The ... similarto the ectodomain-spanning 44/750 mutant, confirming that the ectodomain is a fully active form of the enzyme. Furthertruncation at the N-terminus, or addition of the V5-His tagat the C-terminus,...
- 9
- 414
- 0
Báo cáo khoa học: Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III ppt
... reloca-tion upon inhibitor binding and, in addition, a rota-tion of the Asn257 side chain is necessary toaccommodate the bulky oxodiazolidine ring. Theseobservations are in line with the four-fold ... partially(Fig. 4). One of the reasons for the apparent prefer-ence of the lid to adopt the ‘open’ conformation in GCPIII might be a result of the Gly548 at the C-termi-nus of the lid in GCPII being replaced ... side chain is virtually constant in all reported GCPII struc-tures, the side chains of Arg536 and Arg463 accommo-date variable conformations [29]. The flexibility of the S1 arginines is considered...
- 15
- 355
- 0
Tài liệu Báo cáo khoa học: "Keyword Extraction using Term-Domain Interdependence for Dictation of Radio News" ppt
... and any other domains, domainj seems to be the domain of unit~. The system se- lects the domain which is the largest of all sim- ilarities in N of domains as the domain of the unit (formula ... news into segments according to the length of pauses. We call the segments units. The domain which has the largest similarity between the unit of news and the feature vector of each domain ... as domain of the unit. Finally, the system ex- tracts keywords in each unit using the feature vector of selected domain which is selected by domain identification. Explanations of~ ~ Radio...
- 5
- 414
- 1
Báo cáo khoa học: A new and efficient method for inhibition of RNA viruses by DNA interference pptx
... processeddsDNA, which suggests activation of the cellular machinery involved in silencing of RNA. For the silencing of viral RNA effected with dsDNA,we coined the term DNA interference technology.AbbreviationsAgo, ... multidomain members of the RNase III fam-ily that are responsible for processing long dsRNAsinto effector siRNAs. Human Dicer contains a singlePAZ domain, a single dsRNA-binding domain, andATPase ... the initiation and execution phases of RNAi. Ago proteinsare key components of RISC responsible for the cleav-age of the target RNA. The cleavage is catalysed by aPiwi domain of Ago proteins,...
- 9
- 448
- 0
Báo cáo khoa học: "Big Data versus the Crowd: Looking for Relationships in All the Right Places" docx
... for training and the other pair for testing. We evaluate the precision over the 103highest-probability predictions on the testset. In Figure 5, we vary the size of the corpus in the train pair ... directlyas training examples for our classifier. To generatetraining examples, we need to map the entities backto mentions in the corpus. We denote the relationthat describes this mapping as the relation ... Mintz et al. use a single multi-classclassifier for all relations, Hoffman et al. (2011) anduse an independent binary classifier for each individ-ual relation; the intuition is that a pair of...
- 10
- 454
- 2
Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... obese mice In order to gain insights into the potential biologicallyrelevant role of miR-27 in the regulation of adipose tis-sue functions in vivo, we examined the expression of miR-27 in the genetically ... together, these results illustratea critical and specific role of miR-27 in the regulation of adipogenic differentiation.miR-27 prevents the induction of PPARc andC⁄EBPa In order to delineate ... during differentiation (Fig. 1A, right panel). Wefurther investigated the kinetics of miR-27 expression during adipogenesis using quantitative real-time PCR.As shown in Fig. 1C,D, expression of...
- 11
- 848
- 0
Tài liệu Báo cáo khoa học: Critical roles of Asp40 at the haem proximal side of haem-regulated phosphodiesterase from Escherichia coli in redox potential, auto-oxidation and catalytic control doc
... potential of the haem, rate constants o f CO, O2and CN b inding tohaem, and CD spectra in the Soret region [15–18],suggesting that this residue is critical for maintaining the electronic states of ... binding accesschannel a t t he haem distal side and/or structure in t erms of cyanide binding in the Fe(III) complex.Redox potentials The redox state of haem is related to the PDE activity of Ec ... is the proximal axial ligand of haem. Therefore, a residue interacting with H is77 may p layan important role in regulation of catalysis. Ec DOS formshydrogen networks at the haem proximal side...
- 6
- 423
- 0
Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... BS-RNase.As the dimerization event occurs outside the cells, beforeinternalization, we investigated the role of plasma mem-branes (PM) in the transformation of MSSAE into adimeric protein.125I-labelled ... plateau.These data indicate that the cell sulfhydryls responsible for the exchange with the protein disulfides are located in the plasma membrane. Furthermore, they show that, asproposed in the hypothesis ... thusblocking protein synthesis and leading cells to death. The current model proposed for the mechanism of antitumouraction of BS-RNase is based on the ability of the proteinto resist the neutralizing...
- 8
- 604
- 0
Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP