Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the ﬁsh species Seriola quinqueradiata pot

... Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the ﬁsh species Seriola quinqueradiata Tamotsu ... presence of large amounts of docosahexa-enoic acid and that several acyltransferase activities areinvolved in the process in yellowtail. Materials and methodsMaterialsYellowtails (S. quinqueradiata) ... Lysophospholipid acyltransferase systems of the yellowtail enable PtdIns to accumulate arachidonate in the presence of large amounts of docosahexaenoic acid and a limited supply of arachidonic acid. As PtdIns...

Tài liệu Báo cáo khoa học: Mechanisms of amyloid ﬁbril formation – focus on domain-swapping doc

... between the main-chain amides and the polar side chains. The glu-tamine- and asparagine-rich regions are commonlyfound in the N-termini of both mammalian and yeastprion proteins [96] and several ... con-cluded that domain-swapping may be the rate-deter-mining step [132]. Domain-swapping demands almostcomplete unfolding before the two chains can rearrange and swap strands [132]. Domain-swapped ... original publications are cited. On the basis of our research on cystatins, which are capable of domain-swapping, and on a literature survey of a number of other amyloidogenic proteins that initiallyform...

Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deﬁciency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx

... endothelium lining the cavernosal arteries and the helicine arterioles, as wellas the endothelium lining the lacunar spaces of the corpus cavernsoum; and (c) the endocrine milieu thatregulates the fibroelastic ... E2, contributing further to the decrease in testoster-one concentrations and the preferential accumulation of abdominal fat, leading to androgen deficiency and a hypogonadal state. Thus, obesity ... and release of cytokines and chemokines [122–124]. Andro-gen deprivation therapy is associated with increasedlevels of proinflammatory factors and decreased anti- in ammatory cytokines [125,126]. Interestingly,...

Báo cáo khoa học: Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulﬁram potx

... with bovine serumalbumin as a standard.Enzyme assaysRecombinant NAT1 enzyme activity was determined spec-trophotometrically using PNPA as the acetyl donor and PAS as the arylamine substrate [45]. ... N-acetyltransferases (NATs) are phase 2XMEs that catalyse the transfer of an acetyl groupfrom acetyl-coenzyme A (AcCoA) to the nitrogen oroxygen atom of primary arylamines, hydrazines and their ... 000).Statistical analysis The data are the means ± standard deviation of at leasttwo independent experiments performed in triplicate, unlessotherwise stated. One-way analysis of variance (anova)...

Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt

... of N-acylposphatidylethanolamine-hydrolyzing phospholi-pase D and reduced activity and expression of FAAH.Both the accumulation of anandamide (and of otherN-acylethanolamines) and the protective effects of rimonabant ... Department of Pharmacobiology and University Center for Adaptive Disorders and Headache (UCADH), University of Calabria, Arcavacatadi Rende (CS), Italy A wealth of information has accumulated ... concentrations of either glutamate orGABA, depending on the brain area. Hence, the dif-ferential inhibition of glutamate or GABA in variousexperimental models of cerebral ischemia may be one of the...

Báo cáo khoa học: Mechanisms of cholinesterase inhibition by inorganic mercury potx

... denaturation, and proteinaggregation, protecting the enzyme from denaturation. Mercury-inducedinactivation of cholinesterases is thus a rather complex process. Our resultsindicate that among ... radius increased linearly with mercuryconcentration. Physical changes and protein aggrega-tion occurred in the ﬁrst minute after mercury addi-tion, and the size of the aggregate remained stable ... is availableshould another model be considered, as, for example, in T. californica acetylcholinesterase.Mercury-binding sites on cholinesterasesOrganic and inorganic mercurials are capable of forming...

Báo cáo khoa học: Mechanisms of amyloid ﬁbril self-assembly and inhibition Model short peptides as a key research tool pptx

... crucial role in the fibrillization process [27]. The results of a systematic alanine-scan of a shorterIAPP fragment (Table 1) indicated that other thanphenylalanine, any amino acid within the fragmentcould ... because of a gradualincrease in life expectancy. The genuine understanding of the mechanisms leading to the formation of amyloidfibrils and its inhibition is therefore of high clinicalimportance. ... important informa-tion of the role of aromatic moieties in amyloid fibrilformation [36–41]. A parameter-free model based on the mathematical analysis of many peptide fragments and their analogues...

Báo cáo khoa học: Mechanisms of obesity and related pathologies: Role of apolipoprotein E in the development of obesity potx

... biogenesis of ApoE-containing HDL with the participation of the lipid transporter ABCA1 and plasmaenzyme LCAT. Minimally lipidated ApoE in plasma interacts with ABCA1 (step 1) that is present in the ... circulating ApoE is involved in increasedadiposity and obesity-related metabolic disorders. Of note, the uptake of ApoE-lacking VLDL into the liver and adipocytes was markedly inhibited, althoughadipocytes ... pertinent to the involvement of apolipoprotein E in the development of pathologies associated with the metabolic syndrome.AbbreviationsABCA1, ATP-binding cassette A1 ; ApoE, apolipoprotein E; ApoE)...

Báo cáo khoa học: Mechanisms of obesity and related pathologies: Transcriptional control of adipose tissue development pdf

... continued to produce GFP and remainedmarked. To analyze the rapid and extensive expansion of the adipose lineage during the ﬁrst postnatal30 days (P30), Graff and colleagues [36] treated the LacZ-mice ... both adipose depots and adipocytes. Taken together, the data obtained byGraff and colleagues [36] show that a pool of whiteadipocyte precursors is established perinatally and canproliferate. Additional ... with the new challenge of howto increase its mass and ⁄ or activity as a part of ananti-obesity therapy. Additional knowledge of the molecular mechanisms controlling the formation of alladipose...

Báo cáo khoa học: Mechanisms of obesity and related pathologies: The macro- and microcirculation of adipose tissue pdf

... leptin, the in ammatory chemokines tumor necrosis factor -a (TNFa) and an array of interleukins, and angiogenic and vasoactive molecules such as vascular endothelialgrowth factor (VEGF) and angiotensin ... triggers a high degree of insulin resistance and signs of othermetabolic dysregulation similar to visceral WATexpansion. The importance of maintaining at leastremnants of WAT was demonstrated by injecting ... expansion of WAT results in hypoxia and increased levels of HIF- 1a that, in turn,lead to an up-regulation of the in ammatory adipokin-es interleukin-6, TNFa and monocyte chemotacticprotein-1,...

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