Báo cáo khoa học: "Generalized Encoding of Description Spaces and its Application to Typed Feature Structures" potx

... Generalized Encoding of Description Spaces and its Application to Typed Feature StructuresGerald PennDepartment of Computer ScienceUniversity of Toronto10 King's College Rd.Toronto M5S 3G4, ... definition:Definition 4 Given two BCPOs, and ,is a (generalized) join-preserving encoding of into iff:totality for all , ,disjointness iff ,2We use the notation to mean is undefined, and to mean is defined.fFigure ... join-preserving encoding exists.zero preservation for all and , iff , and join homomorphism for all and , , where they exist.When maps elements of to singleton sets in ,then reduces to a classical...

Báo cáo khoa học:The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks docx

... agiven total flux is obviously equivalent to maintaining agiven rate of biomass production at a minimum of the totalflux. Insofar, the principle of maximal biomass productionis a special case of ... the mathematical basis of the method. The secondpart presents two applications of the method to themetabolism of erythrocytes and of the microorganism,Metylobacterium extorquens AM1 .2906 H ... oxidative p entosephosphate pathway had to be reversed to maintain thetarget fluxes. Then, the NADPH needed to drive thereactions of the o xidative pathway into a backwardsdirection and to form...

Báo cáo khoa học: "Computational structure of generative phonology and its relation to language comprehension." pdf

... idea of the proof is to encode negation and the truth values of variables in features; to enforce clausal satisfication with a local autoseg- mental process, such as syllable structure; and to ... limits us to specifying a polynomial number of features and a polynomial number of rules. Since each feature corresponds to a tape square, ie., the ATM space resource, we are limited to PSPACE ... degrees of vowel height, tone, and stress they allow. Therefore, the set of features must be allowed to vary from language to language, and in principle is limited only by the number of rules...

Tài liệu Báo cáo khoa học: Inhibitory properties of cystatin F and its localization in U937 promonocyte cells ppt

... localization of cystatin F, its restricted and readily regulated expres-sion [18], selective and not too potent inhibition of cathepsins are all in favor of the active role of cystatinF in processes of ... Higherdithiotreitol concentrations than previously reported[12] were needed to restore monomers and inhibi-tory activity under nondenaturing conditions. Loss of inhibitory potential of dimerized ... found that dimers of cystatinF are inactive as inhibitors of cysteine proteases and that the monomeric form has to be restored for theinhibitory potential. After activation of cystatin F wehave...

Báo cáo khoa học: Combined use of selective inhibitors and ﬂuorogenic substrates to study the speciﬁcity of somatic wild-type angiotensin-converting enzyme docx

... use of selective inhibitors as convenient tools to study the spe-cificity of the somatic form of ACE. Thus, with thisapproach, the catalytic property of each domaintowards the hydrolysis of ... identification of a C-domain-specific inhibitor,RXPA380 [13], of human ACE may provide such analternative strategy for studying inhibitor and substrateselectivity of any form of somatic ACE (Scheme 1). To demonstrate ... processed bythe N-domain and C-domain varies according to theACE species. For rat and human enzymes, estimation of IC50values for the binding of the inhibitor to theN-domain and C-domain can be...

Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf

... targeting of CYPs to the ER and mitochondria, Alzheimer’samyloid precursor protein to the plasma membrane and mitochondria, and translocation of the cytosolicglutathione S-transferases to the mitochondrial ... translocation into the mitochon-dria requires a cytosolic chaperone-mediated associa-tion of precursor protein with peripheral translocase of outer membrane (TOM) receptors (TOM20, TOM22 and TOM70), ... micro-somes and mitochondria, whereas truncated cytochrome P450 1A1 (+ 5 and + 33 ⁄ cytochrome P450 1A1) were targeted to mitochondria. Inability to target intact cytochrome P450 1A1 was probably due to...

Tài liệu Báo cáo khoa học: Differential effects of Mxi1-SRa and Mxi1-SRb in Myc antagonism ppt

... constructs weregenerated encoding Myc-tagged versions of these twoisoforms, as well as of the Mxi1-WR isoform that lacksthe SID, and shown to give rise to proteins of theexpected size expressed ... apopto-sis, differentiation, and so on. Isoforms of numerousproteins have been studied and compared in this man-ner, including alternative isoforms of members of thep53 ⁄ p63 ⁄ p73 [23] and ... wasdescribed as a member of the Myc ⁄ Mad ⁄ Max networkby virtue of its having a basic helix-loop-helix leucinezipper (bHLH⁄ LZ) region similar to that of Myc and of its interaction with the...

Tài liệu Báo cáo khoa học: Identiﬁcation of b-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay docx

... range of structural diversity produced by asequence of biosynthetic reactions. Cyclization of oxidosqualene is the ini-tial origin of structural diversity of skeletons in their biosynthesis, and ... modiﬁ-cation of these carbon skeletons and transfer of thesugar moiety (Fig. 1). More than 80 different types of skeleton are generated at the cyclization step [7].Successful cloning of oxidosqualene ... synthase and contribute to theskeletal diversity of triterpenes. Subsequent regio- and stereospeciﬁc hydroxylations of the skeleton producefurther structural diversity. In contrast to the rapidprogress...

Tài liệu Báo cáo khoa học: Thermal unfolding of smooth muscle and nonmuscle tropomyosin a-homodimers with alternatively spliced exons docx

... comparison of Tm5a with smTm allows study of the effects of replacement of muscle exons 1a and 2a by nonmuscleexon 1b, and comparison of Tm5a with Tm5b allowsthe effects of exchange of exon 6 to be ... characteristic of the correctly folded,fully a-helical structure of Tm. The CD spectra of Tm5a and Tm5b were virtually identical to each other and to the spectrum of smTm.Fig. 3. Deconvolution analysis of ... unfolding of homo- and het-erodimers of skeletal [15,16] and smooth [17–19]muscle Tm, their mutants [20–23], and numerouscoiled-coil model peptides corresponding to the N- and C-terminal parts of...

Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx

... between them.Cytotoxicity of RTA N78SRTA N78S was reassociated with RTB and its cytotoxicitywas compared to ricin (Fig. 5B). Ricin containing RTAN78S was approximately twofold less cytotoxic than ... compared to that of wild-typeRTA (Fig. 6A). The reduction in activity of this RTAN122A was 37.5-fold.Cytotoxicity of RTA N122ARTAN122AwasreassociatedwithRTBanditscytotoxi-city was compared to ... and quantification of ricin A-chain variantsPurified RTA (100 lg) was mixed with 100 lgofRTB(Vector Laboratories) and made up to a final volume of 2 mL with NaCl/Picontaining 0.1Mlactose and...

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