... thought to generateproducts with opposing roles, mainly the apoptotic TAisoform(s) and the antiapoptotic DM isoforms. In gen-eral, TAp73 isoforms regulate the transcription of DMp73 isoforms, ... resulting in TAp73 and DMp73 isoforms, respectively. The ulti-mate effect of p73 in oncogenesis is thought to depend on the apoptoticTA to antiapoptotic DN isoforms’ ratio. This study was aimed ... gene pro-duces numerous isoforms as a result of: (a) alternativesplicing in the 3¢-end (leading to the formation of a, b,c, d, e, f and g isoforms) [8–12]; (b) the use of anextrinsic promoter...