Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt
Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf
... speci c and potent HAD inhibitors. Tocheck for covalent modifications of the enzyme, the effect of the inhibitor on the molecular mass value of HAD was measured; instead of an adduct increase, ... periods.Deamidation of any one of the 17 Asn and Gln sites of RNase Aproduces a 1 Da increase in the mass, –CO-NH2fi –CO-OH, of the molecular ions of that product. The observed isotopic abun-dances give calculated ... approach, anincorrect molecular mass value directly indicates the presence of PTMs and ⁄ or an incorrect sequence. Inanother ESI mass spectrum of proteins isolated fromFig. 2. ESI mass spectrum...
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Tài liệu Báo cáo khoa học: "Using adaptor grammars to identify synergies in the unsupervised acquisition of linguistic structure" docx
... each of which consists of a sequence of Words.sible for an adaptor grammar to generate a sentence as a sequence of collocations, each of which con-sists of a sequence of words. These collocations ... generates a Sentence as a sequence of Colloc(ations), each of which is composed of a se-quence of Words, each of which in turn is composed of a sequence of Syll(ables).This grammar achieves a word ... Phoneme+Figure 10: The collocation morphology adaptor gram-mar, which generates each Sentence as a sequence of Col-loc(ations), each Colloc as a sequence of Words, and eachWord as a Stem optionally...
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Báo cáo khoa học: A simple in vivo assay for measuring the efficiency of gene length-dependent processes in yeast mRNA biogenesis doc
... 0.8–1. Acid phosphatase activity of intact cells was assayed as described [19]. The acid phos-phatase activities of the transformants were corrected byM. Morillo-Huesca et al. Assay for gene length-dependent ... of the two THO mutants were dramaticallyreduced when compared with the wild type (Fig. 6). The absence of effect of cdc40D and cus2D on the GLAM ratios was also expected, as no intron islocated ... should reflect the amounts of their respective plasmid-encoded PHO5mRNAs accumulated in the cell. Nevertheless, in orderAB C DFig. 1. Influence of gene-length on mRNA accumulation. (A) Transcription...
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Báo cáo khoa học: Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase l isoform pdf
... backbone and the molecular surface of nuclear domains A and B (see the text) arecoloured green and blue, respectively. The FAD cofactor is shown as red sticks. The figure was produced by usingGRASP ... substanti-ate the hypothesis that these two structural regions aremandatory for the nuclear localization of mSMOl ,as the only difference between mSMOl and mSMO lDproteins consists of the lack of the ... H2O2[7–9].Analysis of the expression of the mouse SMO gene(mSMO), encoding at least nine splice variants, as well as biochemical characterization of the canonical alfaisoform (mSMOa), have been reported recently...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... translo-cation of Bax from the cytoplasm into the mitochon-dria, cytochrome c release and cleavage of caspase-3were all observed (Fig. 4B–D).To confirm the involvement of Bcl-2 and caspase-3in ... mitochondria was increased. Subsequently, cyto-chrome c release and caspase-3 cleavage were observed. TZD-inducedadipocyte apoptosis could be blocked by the caspase-3 inhibitorAc-DEVD-CHO or by ... by Ac-DEVD-CHO. 3T3-L1 adipocytes were treated with 12.5 lM troglitazone in the presence or absence of Ac-DEVD-CHO for 72 or 96 h. Cleaved caspase-3 (Casp3 clved) and total caspase-3 (Casp3)...
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Tài liệu Báo cáo khoa học: Deciphering enzymes Genetic selection as a probe of structure and mechanism docx
... sampled at these positions [9]. Such choicesmay focus the search of sequence space on areas with ahigher frequency of success and thus increase the probability of their detection. In principle, ... selections of Methanococcus jannaschii CM(MjCM) [14] were used to assess the tolerance of a proteinfold to secondary structures of varying sequence [15].MjCM belongs to the AroQ class of CMs whose ... persuasive evidence for the importance of electro-static interactions in catalysis by Bacillus subtilis CM(BsCM).BsCM is a member of the AroH class of CMs. This classadopts a trimeric, pseudo-a/b...
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Tài liệu Báo cáo khoa học: Mammalian mitotic centromere-associated kinesin (MCAK) A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents pptx
... 5. Construction and purification of MCAK184 (A) Schematicrepresentation of the truncated form of the human MCAK con-struct. The homology domain is a ‘clone-14’ sequence. This con-struct was ... by PCR (forward primer: 5¢-ATGGCCATGGACTCGTCGCT-3¢, reverse primer; 5¢-TCACTGGGGCCGTTTCTTGC-3¢). The neck and motor domains of MCAK cDNA (550–1770), conjugated with NdeI and XhoI restriction ... of SQAG activity in cancer cells. These compounds areconsidered to block replicative DNA synthesis by sup-pressing the activity of the DNA polymerases, thusarresting the cell cycle at S and consequently...
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Tài liệu Báo cáo khoa học: "A High-Accurate Chinese-English NE Backward Translation System Combining Both Lexical Information and Web Statistics" pdf
... ofContext ( Where NCTr and NCi denote the appearing times of the rth context CTr and the candidate C i in the returned snippets respectively, and NPTi denotes the total number of ... different cases of the context of C i. Since we want to normalize the entropy to 0~1, we take NPTi as the base of the logarithm function. While concerning context combinations, only capitalized ... a higher statistical score than the correct NE. To prevent such kind of situations, we in-troduce entropy of the context of the candidate. If a candidate has a more varied context, it is more...
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Báo cáo khoa học: Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme–albumin doc
... absence and pres-ence of ibuprofen (final concentration, 1.0 · 10)7to1.0 · 10)2m). The excess of NO was pumped off gentlybefore recording of ligand dissociation kinetics [20]. The kinetics ... the removal of domain I from HSA does not significantlyaffect the functional and structural properties of domains I and II [i.e. of the 1–382 region of (t)HSA].l The values of the Hill coefficients ... penta-coordinated in the absence of allosteric effectors. Indeed, high (> 1.0 · 10)3m) ibu-profen concentration clearly induces the coordination of a histidine nitrogen as the sixth coordination...
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Báo cáo khoa học: Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage docx
... pro-tection from nonspeci c damage. This can occurbecause of the rapid reaction of thiols with many of the damaging species present in biological systems.Furthermore, because many of these ... quench correction. Samples of the [3H] GSH stocksolution were measured to determine its speci c activity.AcknowledgementsThis work was supported by the Medical ResearchCouncil (MRC, UK) and ... blocking the membrane and repeating the immu-noblotting procedure with a different antibody.Other assaysComplex I activity was assessed as the NADH:HAR activ-ity measured by the decrease...
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Từ khóa: báo cáo khoa họcbáo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP