Báo cáo khoa học: Androgen receptor function is modulated by the tissue-speciﬁc AR45 variant ppt

... 20702–20710. Androgen receptor variant form I. Ahrens-Fath et al.84 FEBS Journal 272 (2005) 74–84 ª 2004 FEBS Androgen receptor function is modulated by the tissue-specific AR45 variant Isabelle ... of these effects [18]. Another possibilityarises from the existence of variant forms of steroidreceptors. The estrogen receptor (ER) probablybelongs to the most diversified family. Two isoforms,ERa ... clarify the role of this variant form in disease progression.In conclusion, we have identified AR45, a naturallyoccurring variant of the AR. It may either repress or Androgen receptor variant...

Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx

... proteinswithin the cell. We found this translocation to bedependent on the final amino acids of the receptor protein. Similar to the other PDZ domain interactionsthat have been shown to be abolished by ... expression system.We hypothesized that, by deleting the componentsof the PDZ binding motif, we could disrupt MUPP1translocation. Truncation of the receptor from the finaleight amino acids ... signal is impaired.We finally examined the effect of deletion of the components of the PDZ binding motif on the signal-ing properties of the receptor in Ca2+imagingexperiments. Truncation of the...

Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx

... activation.In addition, the activity of LRH-1 is modulated by post-translational modiﬁcation. The transcriptionalactivity of LRH-1 is stimulated by phosphorylationfollowing 4b-phorbol 12-myristate 13-acetate ... bodies.It is well known that the control of ovarian function and steroid production by gonadotrophins is mainlythrough the activation of the cAMP ⁄ protein kinase Apathway. LRH-1 is an important ... modulate the function ofseveral transcription factors [31].LRH-1 is a target protein of SUMO modiﬁcation[32,33]. The hinge region lysine, residue 289 in the mouse and 224 in the human LRH-1, was the...

Báo cáo khoa học: Synthesis and function of ribosomal proteins – fading models and new perspectives pptx

... conﬁrming the impor-tance of ribosome function in erythropoiesis. Furthersupport for this hypothesis can be obtained by the analysis of other human pathologies, such as dyskera-tosis, cartilage-hair ... cannot be ruled out, the most likely hypothesis is that erythropoiesis is the human developmental pro-cess that is most sensitive to ribosomal defects. Consis-tent with this model, it has been ... for these diseases has revealed that perturbation in the syn-thesis and ⁄ or function of an RP activates a p53-dependent stress response.Surprisingly, the effect of the ribosomal stress is more...

Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

... translocation; this latter function appears tobe the only one that is common to all bacteria. In Yer-sinia, the increased synthesis of LcrV triggered by the activation of the system leads to the titration ... pathogen-speciﬁc, and theirdifferent characteristics and cellular fates inﬂuence the distinct infectious phenotypes of the source microor-ganism [2]. In this review, only the translocons from the three ... organization of the translocon, the hydrophilic translocator is the onlycomponent that is neither directly, nor indirectly asso-ciated with the target membrane; rather, it assemblesinto a distinct...

Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx

... affected by the same siRNA(Fig. 3B, right). To further test whether the inhibitionof Erk activation was caused by the reduction in Shcproteins, rescue experiments were performed using the siRNA-mediated ... cell–cell adhesion and inducesignaling despite the fact that they interact with E-cadherin in different manners. Therefore, it is mostlikely that it is the disruption of E-cadherin-mediatedcell–cell ... weregenerated by the stable transfection of the pSuper retro vec-tor (OligoEngine, Seattle, WA, USA) containing the respective sequences. These cell lines were kindly provided by F Lehembre and G Christofori...

Tài liệu Báo cáo khoa học: "Instance-based Sentence Boundary Determination by Optimization for Natural Language Generation" ppt

... land. The asking price is 1 million dollar and the annual taxesare 8000 dollars. The house is located in the Byram Hills School District.E2 S4 This is a 1 million dollar 3 bedroom house. This is ... This is a 1 million dollar house. This is a 3 bedroom house. This is a 2 bathroomhouse. This house has 2000 square feet. This house has 2 acres of land.This house has 2 car garage. This is ... sentences, the transition from s1to s2 is not quitesmooth. They sound choppy and disjointed. To pe-nalize this, whenever there is a sentence break, there is a SBC. In general, the SBC is a parameter...

Báo cáo khoa học: Dual modulation of prothrombin activation by the cyclopentapeptide plactin pptx

... was included to inhibit the feedback proteolysis ofprothrombin by the generated thrombin). The reaction wasstopped by the addition of an equal volume of acetic acid,and the resulting mixture ... pro-thrombin by the complex (prothrombinase complex) is >105times faster than activation by free Xa [15].Therefore, physiological coagulation is eventually cata-lyzed by the prothrombinase ... mechanism, the presence of plasma is an absolute requirement.u-PA, as well as tissue-type plasminogen activator, is a physiologically relevant protease that catalyzes the limited proteolysis of...

Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt

... 3-hydroxymyristoyl CoA substrate is bio-synthesized by the primary metabolism. Recently, itwas reported that the acyl CoA substrate is transferredto the initiation module SrfA-A1. This transfer is stimulated ... mechanism for the lipidation of daptomycin by DptE and DptF.Decanoic acid is activated by the putativeadenylating enzyme DptE under ATP con-sumption. The fatty acid is then transferredonto the ... stronglydepends on the nature of the acyl moiety [9,10]. The ﬁne tuning between these two features is of consider-able importance for the development of selectivepotent drugs. The biosynthesis of the peptide...

Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx

... to maximize the quality controlof proteins in the secretory pathway. It is not knownwhether the vacuolar function is enhanced by the UPRin plants.Other UPR in plants The UPR is composed of ... con-tain the enormous number of proteins that are activelysynthesized there [192–194]. Therefore, the UPR that is unique to plants is expected to function widely,although the molecular mechanisms ... the ER during seed development, where the UPR is presumed to enhance the ability of the ERto fold these proteins [195]. However, there is currentlyno experimental conﬁrmation of this, and the...

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