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Báo cáo khoa học: Competition between neighboring topogenic signals during membrane protein insertion into the ER pptx

Báo cáo khoa học: Competition between neighboring topogenic signals during membrane protein insertion into the ER pptx

Báo cáo khoa học: Competition between neighboring topogenic signals during membrane protein insertion into the ER pptx

... 2004)doi:10.1111/j.1432-1033.2004.04394.xTo better define the mechanism of membrane protein insertion into the membrane of the endoplasmic reticulum, we measured the kinetics oftranslocation across microsomal membranes of the N-terminal ... Competition between neighboring topogenic signals during membrane protein insertion into the ER Magnus Monne´*, Tara Hessa, Laura Thissen and ... University, Sweden The topology of integral membrane proteins is nor-mally determined at the time of insertion into a target membrane. In both eukaryotic and prokaryotic cells,most membrane proteins...
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Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

... FEBSup into the cells was less than the amount adsorbed to the cell surface. The amounts of the other rhodaminedyes were somewhat higher, but still < 3.5 times the amounts adsorbed to the cell ... and the cells were incubated further.At various time points, cell samples werewithdrawn and the amount of dye associ-ated with the cells was determined aftertheir separation from the external ... and the cells wereincubated further for 30 min. The dye concentrations presented to the cells during the loading phase were chosen in order to yield similarfinal dye contents despite different...
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Báo cáo khoa học: Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae pot

Báo cáo khoa học: Molecular characterization of Osh6p, an oxysterol binding protein homolog in the yeast Saccharomyces cerevisiae pot

... structures without discernibleperipheral staining. These punctate structures were fur-ther found to colocalize with the FM4-64 stainingendosomes (Fig. 3B). Most interestingly, the C-ter-minal half ... in freesterols and  75% increase in sterol esters [32] anderg3D mutants cannot synthesize ergosterol [33]. Con-sistent with these reports, we observed a 38% increasein total ergosterol in ... membranes thus tar-geting Osh6p to membranes; whereas the C terminuscontaining the coiled-coil motif could interact with a protein or protein complex in the other compartment0500100015002000250002000400060008000WT...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... determined the structuraland functional properties of the protein protein inter-action between v-KIND and MAP2. We defined the binding core regions for the v-KIND–MAP2 interac-tion and showed that the ... (Fig. S2B). Taken together, these resultsreveal the specific protein protein interaction between the v-KIND KIND2 domain and the middle CDregion of MAP2.To narrow down the region responsible ... around the middle part of the CD) interacts with the endogenous v-KIND inmouse cerebellum.To verify whether the CD2 region of MAP2 specifi-cally binds to KIND2 in v-KIND, we screened the v-KINDΔKIND1ΔKIND2ΔKIND1+2ΔRasNΔGEFKIND1KIND2KIND1...
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Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc

Tài liệu Báo cáo khoa học: Relationships between structure, function and stability for pyridoxal 5¢-phosphate-dependent starch phosphorylase from Corynebacterium callunaeas revealed by reversible cofactor dissociation studies doc

... were incubated with 100 lMPLP next toeach other in solution. Therefore, heterodimerization wouldhave been possible, and the aim was to either detect it or ruleout its occurrence under the ... form hybrid dimers? Secondly, is there a role ofinteractions between protein and oxyanion during the apofiholo c onversion of CcStP?Complementation of phosphorylase apo-protomers insolution ... unstableconformation. The detailed e xamination of the stepsinvolved in subunit d issociation and reassociation willcontribute to a better understanding of the dimerizationprocess per se and the role of interprotomeric...
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Tài liệu Báo cáo khoa học: Interactions between M proteins of Streptococcus pyogenes and glycosaminoglycans promote bacterial adhesion to host cells pdf

Tài liệu Báo cáo khoa học: Interactions between M proteins of Streptococcus pyogenes and glycosaminoglycans promote bacterial adhesion to host cells pdf

... involved in the interaction as the binding of125I-labelled DS was reduced to isogenicderivatives of the AP1 strain lacking either of these surfaceproteins (Fig. 2). The significance of the M1 protein ... establish the role of M proteins for the GAG interactionwe again first focused on the AP1 system. AP1 expressestwo members of the M protein family; protein M1 and protein H. There was a clearly reduced ... shown). Takentogether, these results suggest that the interaction between S. pyogenes and GAGs is mediated by M protein. Mapping of the DS binding region in proteins M1 and M5To define the region responsible...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "STRING-TREE CORRESPONDENCE GRAMMAR: A DECLARATIVE GRAMMAR FORMALISM FOR DEFINING THE CORRESPONDENCE BETWEEN STRINGS OF TERMS AND TREE STRUCTURES" pdf

... formal properties from the Static Gra~mmar, but with more formal defi- nitions of the properties. In the passage from the Static Grammar to the STCG, the form as well as some other characteristics ... tree. The rule then states that the string of terms ~l, ,ctn corresponds (") to the tree B, while the entry cORRESPONDENCE gives the substring-subtree correspondence between the terms ... expressing these multilevel structures, their related sentences, and the nature of the correspon- dence between the two. In this paper, we present only the grammar formalism ; a discussion on the...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

... derivatives are idealosmolytes, for they neither perturb the denaturationequilibrium nor affect the functional activity undernative conditions. However, they have the ability toprotect proteins ... monophosphate were also obtainedfrom Sigma. These and other chemicals, which were ofanalytical grade, were used without further purification.Dialysis and the determination of the concentration of protein An ... complexes [29]. On the other hand,kcat⁄ Kmis an apparent second-order rate constant thatrefers to the properties and the reaction of the freeenzyme and free substrate [29]. We have therefore esti-mated...
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Báo cáo khoa học: Interactions between coenzyme B12 analogs and adenosylcobalamin-dependent glutamate mutase from Clostridium tetanomorphum pot

Báo cáo khoa học: Interactions between coenzyme B12 analogs and adenosylcobalamin-dependent glutamate mutase from Clostridium tetanomorphum pot

... speculation that proteinsmight modulate the pKaof the histidine via the hydrogen bond between the His–Asp pair and so ‘finetune’ the reactivity of AdoCbl. Mutations of eitherresidue result ... coenzyme protein interactions have previously beenprovided to support the steric effect to explain the cobalt–carbon cleavage mechanism. The binding energy for AdoCbl comes from inter-actions between ... CobU protein, in 50 mm Tris ⁄ HCl, pH 8.5,and other solutions used for the reaction were madeanaerobic and equilibrated using alternate cycles of vacuumand hydrated argon gas for 15 min. The...
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Báo cáo khoa học: Interaction between Lim15/Dmc1 and the homologue of the large subunit of CAF-1 – a molecular link between recombination and chromatin assembly during meiosis pot

Báo cáo khoa học: Interaction between Lim15/Dmc1 and the homologue of the large subunit of CAF-1 – a molecular link between recombination and chromatin assembly during meiosis pot

... that the N-terminus of CcCac1L preferentially interactswith CcLim15. Co-immunoprecipitation experiments showed that theseproteins also interact in the crude extract of meiotic cells. Furthermore, ... as a novelinteracting partner of CcLim15. Furthermore, it wasshown that CcCac1L interacts with CcPCNA during the meiotic prophase. Several DNA synthesis eventstake place during the meiotic prophase, ... contained the KER domain, whereas the C-terminus (CcCac1L-C; amino acids 382–812) contained the ED domain(Fig. 1B). Two-hybrid assays demonstrated thatCcLim15 interacts with either of the truncatedmutants...
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