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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt

Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt

Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt

... 3413 NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au) peptide complex from docking calculations Andreas ... D esign and synthesis of a p otent c yclic ana-logue of the myelin basic p rotein epitope MBP72-85: importance of the Ala81 carboxyl group and of a cyclic conformation for induction of experimental ... (http://www .nmr. chem.uu.nl/haddock) using the standard protocols. The a mbiguous interaction r estraints for docking calculations were defined for the P4, P6 and P9pockets of the peptide- binding groove of the MHC II (I-Au),...
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Báo cáo khoa học: Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4 docx

Báo cáo khoa học: Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4 docx

... added to the reaction. The protein amount of GST–Six1was 16 ng for probe A (lanes 1–7), 15 ng for probe B (lanes 8–12) and 13 ng for probe C (lanes 13–17). The intensities of the retardedbands ... oligos 2, 3 and 6 for probe A, by oligos 6 and 7 for probe B and by oligos 6, 7 and 9 for probe C (Fig. 3B). In contrast, the formation of a complex by Six4 was competed onlyby oligo 9 for probe ... revealed specific anomalies in ear-lier stages of otic and nasal development and in the formation of branchial arch and some cranial ganglia,which were not observed in Six4– ⁄ –mice and Six1– ⁄...
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Báo cáo khoa học: Glycosphingolipids in Plasmodium falciparum Presence of an active glucosylceramide synthase pot

Báo cáo khoa học: Glycosphingolipids in Plasmodium falciparum Presence of an active glucosylceramide synthase pot

... with chloroform (20 mL), chloroform/methanol(98 : 2, v/v, 20 mL) and chloroform/methanol (1 : 3, v/v,25 mL) [16].In another experiment, total lipids from schizont formswere extracted and purified ... (pH 7.4). The mixture was extracted with chloroform/methanol (1 : 1) and analysed by TLC in chloroform/methanol/water (65 : 25 : 2, v/v/v). Lanes 1, 2 and 3 are rings, trophozoites and schizonts,respectively, ... fraction (II) , trihexosylceramide fraction (IV) and tetrahexosylcera-mide fraction (V) were extracted from the plate and analysed by UV-MALDI-TOF MS.Acid methanolysis and methylation The sample...
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Báo cáo khoa học: NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B–NS3 protease ppt

Báo cáo khoa học: NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B–NS3 protease ppt

... NS2B–NS3pro, whereas the 3D NMR experi-ments of the complexes with 2 and 3 employed the WNV NS2B–NS3pro(K96A) mutant. The resonanceassignments of the complexes with 1 and 3 were sup-ported ... spectra of combinatorially15N-labelled samples of WNV NS2B–NS3pro in the presence of 1.Fig. S4. 800 MHz 1D1H NMR spectra of the com-pounds 2 and 3 in the absence and presence of WNVNS2B–NS3pro(K96A) ... presented the dissociation constant of 3measured by NMR and, as additional proof for bind-ing of 3 to the substrate-binding site, demonstratedchanges in cross-peak positions for residues lining the substrate-binding...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf

Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf

... alignment of eRF1.Fig. S11. The Ramachandran map plot (/ and w tor-sion angles for the protein backbone) of all 24 con-formers of the NMR families of solution structures of the closed and open conformers ... than 99% of the 1H,13C and 15N atoms of the protein backbone, and for more than 78% of the side chain atoms. The main set of backbone u and w dihedral angles wascalculated from the chemical ... conformer and near Glu365 and Glu367 in the closed conformer, and these polarinteractions may play an important role in the stabil-ization of the two conformers. The two His residues,His334 and...
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Báo cáo khoa học: A new molecular tool for transgenic diatoms Control of mRNA and protein biosynthesis by an inducible promoter–terminator cassette docx

Báo cáo khoa học: A new molecular tool for transgenic diatoms Control of mRNA and protein biosynthesis by an inducible promoter–terminator cassette docx

... Structure of transformation plasmid pNICgfp and analysis of GFP expressing C. fusiformis transformants. (A) Restriction map of the part of plasmid pNICgfp containing the egfp gene flanked by the Pnr ... that the 5¢-UTR and 3¢-UTR of CfNR allow control of both the timing and level of expression of introducedgenes in transgenic C. fusiformis.ResultsIncreasing the efficiency of C. fusiformistransformationPreviously, ... cyto-kinesis and valve and girdle band formation which arecompleted in less than 1 h. In future, analysis of celldivision or valve formation in C. fusiformis transform-ants carrying a gene of interest...
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Tài liệu Báo cáo khoa học: NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles doc

Tài liệu Báo cáo khoa học: NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles doc

... designates the N-terminaltransmembrane helix of the protein. On the basis of the three sets of secondary shift data in Fig. 3 (right), the helices probably range from I39 to E48 (helix 2) and from ... generates aRamachandran plot for assessment of the geometric quality of protein conformers. The coordinates of the 20 lowestenergy structures have been deposited in the RCSB Protein Data Bank under ... turn formed, whereas only  40% of unorderedconformations remained. NMR spectroscopy and resonance assignment The experimental conditions for the NMR study of VpUcyt in the presence of membrane-mimickingmicelles...
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Tài liệu Báo cáo khoa học: Neuropeptide Y-family receptors Y6and Y7in chicken Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region docx

Tài liệu Báo cáo khoa học: Neuropeptide Y-family receptors Y6and Y7in chicken Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region docx

... aliquoted and stored at )80 °C.Peptides and nonpeptide ligandsChicken PYY and PP were ordered from Schafer-N(Copenhagen, Denmark). For the studies of Y6, pNPY and pPYY peptides were purchased from ... cloned and studied the tissue dis-tribution and phylogeny of the chicken Y6 and Y7re-ceptors and performed the initial pharmacologicalcharacterization of the latter. It is clear, from these studies, ... human and severalother primates [32,34,36], pig [37] and guinea-pig [38], and it has been lost in rat [39]. On the other hand, the gene has an intact open reading frame in a distantrelative of...
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Tài liệu Báo cáo khoa học: Phylogenetic relationships in class I of the superfamily of bacterial, fungal, and plant peroxidases pptx

Tài liệu Báo cáo khoa học: Phylogenetic relationships in class I of the superfamily of bacterial, fungal, and plant peroxidases pptx

... (Chlamydomonas sp. and Chlamydomonasreinhardtii) and all t hylakoid APXs from h igher plantsanalysed here. An important observation is the occurrence of two different APXs from the same organism (e.g.thylakoid ... i.e. the CCP line and the KatG fusion line, as is the c ase for Neuro spora crassa[47].Evolution by the birth -and- death process in class I of the superfamily of bacterial, fungal, and plant ... [12], and thus the role of the corresponding part of the gene is alsounknown. These g ene f usions togeth er with single-copygenes of APXs and CCPs are ideal for investigating the evolution of...
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Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx

Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx

... 0.2 units of activity of the purified (lanes 1, 3 and 5) and recombinant (lanes 2, 4 and 6) enzymes were used. Lanes 1 and 2, E. quadrivirgata enzyme; lanes 3 and 4, E. climacophoraenzyme; lanes ... far from amphibian enzymes, but closeto mammalian and avian DNases I.Thermal stabilities of wild-type and substitutionmutant snake DNases I The thermal stabilities of the wild-type and mutantenzymes ... cell turnover and thus for the prevention of systemic lupus erythematosus (SLE) [12]. The gene product of human DNASE1*6 was morethermally unstable than that of the other alleles and subjects...
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