... divergence in
chromatin remodelling. One of the most distinctive
characteristics of chromatin remodelling during
spermatogenesis is the expression of a large number of
histone variants. Indeed, in ad ... H3.3 is incorporated during the first meiotic
prophase, then concentrated in a limited number of
chromatin regions and further disappears with the other
co...
... undergoes fusion with the
membrane of intra-endosomal vesicles contained within MVBs,
thereby releasing the nucleocapsid into the lumen of these vesi-
cles. Then, the capsid uses these intra-endosomal ... mild
developmental delay. The protein defective in this disorder is also
a NHEJ protein. The distinct clinical features of the patients will
be discussed in the con...
... focus and determines
how the focus moves according to the signals which the speaker
uses in discourse to indicate the movement.
Given a process notion of focus, the paper reviews the
difficulties ... by means of rules for antecedence.
I.
The
focus provides a source of
antecedence in rules for interpreting
pronominal anaphora.
2. Focussing provides a control fo...
... equal sharing of initiative — the expert had ini-
tiative for 60% of the turns in finance ADs and
51% of the turns in software ADs. This is because
in the ADs, the novice must communicate the de-
tails ... learning
(i.e.,
task success for the tutor). Surpris-
ingly, students had initiative more of
the time in the didactic dialogues (21%
of the turns) tha...
... equivalent in nin-
hydrin colour to 1.0 l mol of leucine in 5 h at pH 7.4 at 37 °C in the
presence of CaCl
2
. Data are expressed as the mean ± SD of three
independent experiments. (C) The ratio of hydrolytic ... combined
thermodynamic and crystallographic study of trypsin
and thrombin inhibition. J Mol Biol 313, 593–614.
33 Blevins RA & Tulinsky A (1985) The refine...
... through
the REST ⁄ NRSF chromatin remodeling complex sug-
gests a central role of this kinase in brain pathology
[10]. Expression of DYRK1A in neurons during fetal
and postnatal life, as well as in ... speckles, the
site of storage of inactivated serine⁄ arginine-rich pro-
teins, including ASF. This mechanism prevents ASF
from facilitating tau exon 10 inclusion and upr...
... through
the exchange between subunits of either their N-ter-
minal, or their C-terminal ends [33–35]. We found
that the behavior with the model membrane of the
dimer in which the C-terminal ends ... region, and (b) their cytotoxic
action. This finding strongly suggests that the elec-
trostatic surface potential of a defined 3D district of
these proteins has a role in d...
... likely that the N-terminal domain is involved in
protein–protein interactions with other hydrophilic domains
of neighboring integral membrane subunits, and interspecies
interactions are incompatible.
From ... be inserted
into the inner membrane, but it is missing a major portion
of the domain localized in the intermembrane space. A
comparison of all the known mammalian E...
... N-linked oligosaccharide side-chains
are important for the GABA transport activity.
1-Deoxymannojirimycin inhibits the GABA-uptake
of GAT1
In order to gain further insight into the role of the
terminal ... results in reduction
of the stability of GAT1
In order to study the in uence of the N-glycosylation
and N-linked oligosaccharides on protein stability, the...
... further
investigate the role of the SEA domain in cleavage of
membrane-tethered mucins we carried out site-directed
mutagenesis of the FRPG ⁄ SVVV site and evaluated
hybrid mucins in which the ... according to the intensity of M2-reactive
species in the corresponding whole cell lysate.
Molecular modeling of SEA domain of MUC1
The composer and biopolymer modul...